Pressure controlled drug release in a Zr-cluster-based MOF

Abstract

A Zr-cluster-based MOF ZJU-800 was synthesized with high drug loading capacity for controllable drug delivery from 2 days to 8 days.

Recent advances in metallopolymer-based drug delivery systems

“…A redox-and thermos-responsive gated supramolecular star polymers were obtained using the host-guest complexation of a 6-fold b-CD functionalized core molecule and Fc end modied poly(N,Ndimethylacrylamide) and poly(N,N-diethylacrylamide) linear polymers. 250 In addition to the similar systems discussed here, it should be noted the development of temperature-, [251][252][253] pressure-, 254 humidity-, 255 competitive binding agent-, 256,257 liposomeresponsive 258 and other stimuli-responsive metallopolymers used as DDSs. However, using multiple stimuli-responsive polymers is more effective to achieve more precise cancer therapies.…”

Metal–Organic Framework (MOF)‐Based Drug/Cargo Delivery and Cancer Therapy

“…In addition to the above commonly mentioned stimuli, pressure has also been employed for controllable drug release. Recently, Qian and co‐workers reported a Zr‐based MOF builted from (2E,2E′)‐3,3′‐(2‐fluoro‐1,4‐phenylene) diacrylic acid (F‐H 2 PDA) and zirconium cluster with high model drug diclofenac sodium (DS) loading capacity of 58.80 wt% due to its enhanced polarity and extended organic spacer . The DS‐release kinetics of such drug‐loaded MOF could be adjusted through varying pressure, resulting in a prolonged release time between 2–8 days.…”

Application of zirconium MOFs in drug delivery and biomedicine

“…For MOFs, release of cargo can occur by diffusion out of the pores or through degradation of the MOF itself, with unwanted early releasethe so-called "burst release" Figure 12a) [110], and 15 days instead of two for amorphous UiO-66-NH 2 [105]. Similarly, the release of (DS) from ZJU-800, a member of the UiO series linked by 3,3ʹ-(2-fluoro-1,4-phenylene)diacrylic acid, was monitored in PBS by Jiang et al [111]. DS was loaded into ZFU-800 up to 59% w/w, and its release in PBS (pH 7.4) at 37 °C displayed a burst effect, with an immediate 10% release, followed by full release over two days.…”