Preserve Common Limb in Duodenal–Jejunal Bypass Surgery Benefits Rats with Type 2-Like Diabetes

Zhang, Shi Yun; Sun, Xuejun; Zheng, Jian; Wang, Wei; Liu, Dong; Chen, Nan Zheng; He, Shan; Huo, Xiong Wei; Smith, Wanli W.

doi:10.1007/s11695-013-1103-z

Cited by 6 publications

(1 citation statement)

References 36 publications

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“…Despite this, both vertical sleeve gastrectomy and RYGB are effective in normalizing glycemia in several models of models of GLP-1R deficiency (48,49), whereas duodenal-jejunal bypass (DJB) improves glucose levels despite nonelevated postsurgical GLP-1 levels in nonobese type 1 diabetic rats (50). Thus, the role of GLP-1 in mediating the antidiabetic effects of bariatric surgery still remains highly controversial (44,45,(51)(52)(53)(54)(55).…”

Section: Glp-1 Action In the Gutmentioning

confidence: 99%

Hormonal Signaling in the Gut

Côté

Zadeh-Tahmasebi

Rasmussen

et al. 2014

Journal of Biological Chemistry

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The gut is anatomically positioned to play a critical role in the regulation of metabolic homeostasis, providing negative feedback via nutrient sensing and local hormonal signaling. Gut hormones, such as cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1), are released following a meal and act on local receptors to regulate glycemia via a neuronal gut-brain axis. Additionally, jejunal nutrient sensing and leptin action are demonstrated to suppress glucose production, and both are required for the rapid antidiabetic effect of duodenal jejunal bypass surgery. Strategies aimed at targeting local gut hormonal signaling pathways may prove to be efficacious therapeutic options to improve glucose control in diabetes.

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