Preservation Solutions for Solid Organ Transplantation

Abstract

Solid organ transplantation was one of the greatest medical advances of the 20th century. Current preservation technology falls short of maintaining organs ex vivo in perpetuity. This review examines the biochemical basis of organ degradation in response to ischaemia, preservation solution composition and potential future organ preservation technology.

Transplantation of the uterus in the sheep: oxidative stress and reperfusion injury after short-time cold storage

“…In transplantation of vital organs, the possibility of retrieving and transplanting an organ in close temporal and spatial proximity may be limited, and often, transportation is necessary. Therefore, much effort has been put into development of methods to reduce the severity of ischemia-reperfusion injury, and several different kinds of preservation solutions have been invented and evaluated extensively for organs used for transplantation over the years (27,28). In the present study, the extracellular-like preservation solution Perfadex was compared with Ringer's acetate.…”

Evaluation of silybum marinaum efficacy on University of Wisconsin and histidine-tryptophan-ketoglutarate solutions latter the damage of the perfused liver

“…Furthermore, HTK solution, firstly used for heart donors with its low potassium ingredient, has demonstrated effective in organ transplantations. However UW solution includes, electrolytes especially potassium in elevated concentration, also UW solution is increase the vessel efficacies 13,14 .…”

“…Different from other studied molecules silybum marinaum has glutathion which supply cytoprotective effect reduces the inflammatory reaction and inhibit the fibrogenesis of liver. The aim of this research was to evaluate the applying of Silybum Marinaum (silymarin, S) in the aspect of improving the antioxidant and cellular preserving efficacies of HTK and UW solutions [1][2][3][4] .…”

Flow distribution during infusion of UW and HTK solution in anaesthetised rats

“…The solutions are administered chilled and at a flow rate lower than that of normal blood flow to the abdominal organs. At present, UW solution is the most widely used since it can be applied to all abdominal organs and also, to some extent, for hearts and lungs [1][2][3]5]. Also, HTK solution, initially used for heart preservation with its low potassium content, has proven effective in abdominal transplantations [13].…”

“…Most of these solutions are adapted to alleviate adverse metabolic consequences, such as hypoxia and cell swelling [1][2][3][4]. To accomplish this, many of the solutions have an intracellular electrolyte composition [e.g.…”