Transplantation of the uterus in the sheep: oxidative stress and reperfusion injury after short-time cold storage

Wranning, Caiza A.; Dahm‐Kähler, Pernilla; Mölne, Johan; Nilsson, Ulf; Enskog, Anders; Brännström, Mats

doi:10.1016/j.fertnstert.2007.07.1340

Cited by 58 publications

(54 citation statements)

References 39 publications

(36 reference statements)

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“…The larger utero‐ovarian vein (8 mm diameter) was then anastomosed end‐to‐side to the external iliac vein. Parameters related to glucose metabolism, oxidative stress and pH levels of the uterine venous blood normalized within 30 min in 70% of the autotransplanted uteri 72 …”

Section: Uterus Transplantationmentioning

confidence: 95%

Transplantation of female genital organs

Brännström

Díaz-García

2011

J of Obstet and Gynaecol

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Transplantation of gynecological organs is a medical field where considerable advancements have been made in research during the last 25 years and with some procedures already introduced as clinical treatments. These types of transplantations aim at curing permanent infertility. Uterus transplantation has been proven to be a feasible procedure in different experimentation animal models with proof of concept concerning surgery, control of rejection and fertility. There has already been one human transplantation attempt, which, however, was unsuccessful. Based on the progress in this area, we predict that the first successful uterus transplantation attempt will come within 2-3 years. Orthotopic ovarian cortex transplantation has overcome the status of an experimental procedure since more than 20 pregnancies have been reported. Its main field of application is fertility preservation in oncologic patients undergoing high gonadotoxic risk therapies. The role of heterotopic ovarian cortex transplantation still remains at the research level, although co-transplantation with an orthotopic cortex might facilitate a more accurate endocrine environment. The major drawback of ovarian cortex transplantation remains the long ischemic interval between re-implantation and the establishment of neovascularization. Whole ovary cryopreservation followed by transplantation through vascular anastomosis may emerge as an important procedure in this field, because the warm ischemic time would be reduced from several days to less than 1 h, which will most likely improve follicle survival. In summary, transplantation surgery is also entering the field of gynecology and in the future several types of transplantations of organs/tissues of the female reproductive tract may become established clinical procedures.

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Section: Uterus Transplantationmentioning

confidence: 95%

Transplantation of female genital organs

Brännström

Díaz-García

2011

J of Obstet and Gynaecol

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“…The insufficiency of basic studies in this field was pointed out, and since then, basic research using animal species was started. The animal experiments regarding UTx have been conducted on small animals, such as mice, rats, and rabbits, large animals (including pigs and sheep), and non‐human primates like monkeys and baboons . Many results regarding transplantation techniques, postoperative management, immunosuppression methods, and so on have been obtained …”

Section: Basic Animal Researchmentioning

confidence: 99%

Uterus transplantation: Toward clinical application in Japan

Suganuma

Hayashi

Kisu³

et al. 2017

Reprod Medicine & Biology

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BackgroundIn recent years, uterus transplantation (UTx) has been applied as the treatment for patients with uterine factor infertility worldwide. Thus, the clinical application of UTx in Japan should be considered through both the history of UTx technology development in the world and future prospects.MethodsRecent information on UTx was collected via a literature survey and the Internet.ResultsBasic research using various animals has been done mainly since 2000. In 2014, the world's first UTx baby was born in Sweden. In total, 24 UTx procedures have been performed at 10 institutes in nine countries and five births were obtained (as of May, 2017). In Japan, the “Project Team for Uterus Transplantation” initiated UTx experiments in 2008 and the “Japan Society for Uterus Transplantation” was organized in March, 2014. In the rest of the world, the “International Society for Uterus Transplantation” was established in January, 2016.ConclusionUterus transplantation is still under development as a reproductive medicine tool and organ transplant procedure. A collaborative system that is not limited by facilities and specialties should strive to build an “all‐Japan” team.

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“…The early changes at reperfusion of the sheep uterus were studied after the 1 hour of cold ischemia and after another 1 hour of warm ischemia (40). During reperfusion, several parameters related to glucose metabolism, oxidative stress, and inflammation reversed to normality within 1-2 hours, indicating that the uterus has the capacity to tolerate 1 hour of the tissue-damaging warm ischemia.…”

Section: Autologous Utxmentioning

confidence: 99%