Preservation of the Liver Graft With Celsior Solution

García-Gil, Francisco A.; Arenas, Juan; Güemes, Antonio; Esteban, E.; Tomé-Zelaya, E.; Lamata, Félix; Sousa, Ramón; Jiménez, Antonio José González; Barrao, M.E.; Serrano, M.T.

doi:10.1016/j.transproceed.2006.08.032

Cited by 22 publications

(19 citation statements)

References 8 publications

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“…The decreased potassium content was designed to lower calcium‐associated contractures and by this to reduce endothelial impairment and biliary tract damage. UW solution compared to Celsior showed comparable results with respect to efficacy and safety for liver graft preservation 92, 93. A UW–polyethylene glycol (PEG) solution called Institute George Lopez combines a cationic inversion of the potassium and sodium concentrations and replacement of hydoxyethyl starch with PEG.…”

Section: Optimizing the Graftmentioning

confidence: 99%

Preconditioning, organ preservation, and postconditioning to prevent ischemia-reperfusion injury to the liver

Rougemont¹,

Lehmann²,

Clavien³

2009

Liver Transpl

123

113

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and reperfusion lead to injury of the liver. Ischemia-reperfusion injury is inevitable in liver transplantation and trauma and, to a great extent, in liver resection. This article gives an overview of the mechanisms involved in this type of injury and summarizes protective and treatment strategies in clinical use today. Intervention is possible at different time points: during harvesting, during the period of preservation, and during implantation. Liver preconditioning and postconditioning can be applied in the transplant setting and for liver resection. Graft optimization is merely possible in the period between the harvest and the implantation. Given that there are 3 stages in which a surgeon can intervene against ischemia-reperfusion injury, we have structured the review as follows. The first section reviews the approaches using surgical interventions, such as ischemic preconditioning, as well as pharmacological applications. In the second section, static organ preservation and machine perfusion are addressed. Finally, the possibility of treating the recipient or postconditioning is discussed.

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Section: Optimizing the Graftmentioning

confidence: 99%

Preconditioning, organ preservation, and postconditioning to prevent ischemia-reperfusion injury to the liver

Rougemont¹,

Lehmann²,

Clavien³

2009

Liver Transpl

123

113

View full text Add to dashboard Cite

show abstract

“…Moreover, vessel walls are extremely vulnerable and are sensitive to traction or mechanical compression. Therefore, the role of preservation solution in vessels transplantation outcomes is essential . A so far unresolved complication of allogeneic vessels transplant is proper preservation.…”

Section: Discussionmentioning

confidence: 99%

University of Wisconsin vs normal saline solutions for preservation of blood vessels of brain dead donors: A histopathological study

Kazemi

Nikeghbalian

Yaghmaei

et al. 2018

Clinical Transplantation

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“…To date, UW solution has remained the gold standard solution against which all other solutions are compared [25] . There is no evidence from randomized controlled trials that any of the other solutions such as Celsior solution or histidine-tryptophanketoglutarate solution result in a better graft or patient survival than UW solution [26][27][28][29][30] .…”

Section: Static Cold Storage and Storage Solutionsmentioning

confidence: 99%

Current protective strategies in liver surgery

Gurusamy

González²,

Davidson³

2010

WJG

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During liver resection surgery for cancer or liver transplantation, the liver is subject to ischaemia (reduction in blood flow) followed by reperfusion (restoration of blood flow), which results in liver injury [ischemia-reperfusion (IR) or IR injury]. Modulation of IR injury can be achieved in various ways. These include hypothermia, ischaemic preconditioning (IPC) (brief cycles of ischaemia followed by reperfusion of the organ before the prolonged period of ischaemia i.e. a conditioning response), ischaemic postconditioning (conditioning after the prolonged period of ischaemia but before the reperfusion), pharmacological agents to decrease IR injury, genetic modulation of IR injury, and machine perfusion (pulsatile perfusion). Hypothermia decreases the metabolic functions and the oxygen consumption of organs. Static cold storage in University of Wisconsin solution reduces IR injury and has prolonged organ storage and improved the function of transplanted grafts. There is currently no evidence for any clinical advantage in the use of alternate solutions for static cold storage. Although experimental data from animal models suggest that IPC, ischaemic postconditioning, various pharmacological agents, gene therapy, and machine perfusion decrease IR injury, none of these interventions can be recommended in clinical practice. This is because of the lack of randomized controlled trials assessing the safety and efficacy of ischaemic postconditioning, gene therapy, and machine perfusion. Randomized controlled trials and systematic reviews of randomized controlled trials assessing the safety and efficacy of IPC and various pharmacological agents have demonstrated biochemical or histological improvements but this has not translated to clinical benefit. Further well designed randomized controlled trials are necessary to assess the various new protective strategies in liver resection.

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Preservation of the Liver Graft With Celsior Solution

Cited by 22 publications

References 8 publications

Preconditioning, organ preservation, and postconditioning to prevent ischemia-reperfusion injury to the liver

Preconditioning, organ preservation, and postconditioning to prevent ischemia-reperfusion injury to the liver

University of Wisconsin vs normal saline solutions for preservation of blood vessels of brain dead donors: A histopathological study

Current protective strategies in liver surgery

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