Preservation of ovarian function and reproductive ability in patients with malignant ovarian tumors

Miyazaki, Toshihide; Tsutsumi, Yutaka; Ohta, Makoto; Kano, T; Mizuno, Kazuo; Sakakibara, Katsumi

doi:10.1016/0090-8258(88)90247-8

Cited by 19 publications

(10 citation statements)

References 7 publications

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“…Therefore, in several series epithelial and nonepithelial tumor were mixed 11,12 and in others invasive and LMPT were even included. 13,14 Accordingly, the interpretation of results in such situations becomes confusing. Other studies about the outcome of conservative surgery in EOC included 10 or fewer patients.…”

Section: Discussionmentioning

confidence: 99%

Results of conservative treatment in epithelial ovarian carcinoma

Morice

Wicart-Poque

Rey

et al. 2001

Cancer

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Section: Discussionmentioning

confidence: 99%

Results of conservative treatment in epithelial ovarian carcinoma

Morice

Wicart-Poque

Rey

et al. 2001

Cancer

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“…In our experience, there was no significant difference in the time taken to resumption of a normal menstrual cycle between the patients with platinum-based chemotherapy and those with non-platinum-based therapy. Several studies 7,12,15,17,[22][23][24][33][34][35] have reported on pregnancies after chemotherapy for ovarian cancer. Some of these report sterility in 30% to 44% of patients.…”

Section: Discussionmentioning

confidence: 99%

“…[24][25][26] Kanazawa 7 reported that all 8 patients who received conservative surgery for stage I malignant epithelial tumors of the ovary, including stage Ic disease due to intraoperative rupture of the capsule, were alive with no evidence of disease. Our experience in the present series implied that the prognosis for stage I malignant epithelial tumors, excluding clear cell adenocarcinoma, was not significantly dependent on whether or not the uterus and contralateral ovary were resected.…”

Section: Discussionmentioning

confidence: 99%

Conservative surgery for malignant ovarian tumor in women of childbearing age

Jobo

Yonaha

Iwaya

et al. 2000

International Journal of Clinical Oncology

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Background. The traditional operative procedures for the treatment of ovarian cancer have been simple total hysterectomy, bilateral salpingo-oophorectomy, and omentectomy. However, young patients who want to preserve fertility are occasionally encountered. This study was designed to assess the results of conservative surgical management for young women with stage I epithelial ovarian carcinoma or malignant germ cell tumor and to explore the indications for such surgical treatment. Methods. Fifty-eight patients aged under 35 years were treated for malignant ovarian tumors (germ cell tumor, n = 20; epithelial tumors, n = 38) between 1971 and 1996. We studied all 20 patients with germ cell tumors and 22 pa-tients with stage I epithelial tumors; we excluded the 12 patients with stage II and more advanced disease and the 4 patients with stage I clear cell carcinoma, because these patients had poor prognoses. Eleven of the 22 patients with stage I epithelial tumors and 8 of the 20 patients with germ cell tumors received conservative surgery (conservative surgery group); the remaining 23 patients underwent radical surgery, including hysterectomy and bilateral salpingo-oophorectomy (radical surgery group). The overall survival rates of the two groups were compared, and ovarian function and pregnancy outcome were evaluated in the conservative surgery group. Results. Of the patients with malignant epithelial tumor who were treated with conservative surgery, 3 patients with stage Ic mucinous adenocarcinoma died 1 year and 8 months, 7 years and 6 months, and 8 years, respectively, after the initial surgery. The 10-year survival rate was 65% for the conservative surgery group and 91% for the radical surgery group. All patients with stage Ia epithelial tumors in both groups survived, and there were no differences in survival curves between the two groups among the patients with stage Ic epithelial tumors. All patients with germ cell tumors in the conservative surgery group survived. Their survival rate, however, was not significantly better than that in the radical surgery group. All patients with germ cell tumors who received platinum-based chemotherapy survived and had a significantly better survival rate than those who received non-platinum-based regimens (P < 0.05). All the patients in the conservative surgery group received postoperative chemotherapy; 10 of these patients had transient ovulation failure after the completion of chemotherapy, although a normal menstrual cycle was restored within 1 year. Of the 10 patients who wished to have babies, 6 became pregnant, and they have had a total of 11 children. Conclusion. Conservative surgery is feasible in patients with stage Ia epithelial carcinoma and germ cell tumor. Postoperative chemotherapy suppressed ovarian function in these patients, but only for a brief period.

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“…D'autre part elles ont une probabilité de survie trè s supé rieure aux femmes plus â gé es, à histologie, stade et grade é gaux [6,27]. E n f i n l es c a p a c i t é s de procré ation diminuent fortement avec l'â ge.…”

Section: L'â Geunclassified

“…La duré e de celle-ci rallonge le dé lai. Il semble que certains protocoles comme le VAC puisse occasionner des amé norrhé es dé finitives [27]. Pour d'autres la reprise de la fonction cyclique est presque constante mais peut aller avec des troubles endocriniens et en particulier avec une é lé vation des taux basaux de FSH et LH.…”

Section: Le Cas Particulier Des Dé Couvertes Fortuitesunclassified