Results of conservative treatment in epithelial ovarian carcinoma

Morice, Philippe; Wicart-Poque, F.; Rey, B S Annie; El-Hassan, Janah; Pautier, Patricia; Lhommé, C.; Crevoisier, R. de; Haie-Méder, Christine; Duvillard, P.; Castaigne, Damienne

doi:10.1002/1097-0142(20011101)92:9<2412::aid-cncr1590>3.0.co;2-7

Cited by 90 publications

(46 citation statements)

References 32 publications

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“…The results are in agreement with other studies [5][6][7][8] in both early ovarian cancer and borderline tumors [9]. There has always been a demand for less radical surgery and fertility sparing surgery if the treatment is reasonably safe.…”

Section: Discussionsupporting

confidence: 91%

“…Sparing the uterus should be an option even in true stage Ib if no peritoneal tumor spread is found in order to later be able to perform embryo transfer with donated eggs. At our institution the recommendation has so far been to suggest prophylactic oophorectomy of the contra lateral ovary and hysterectomy after completion of childbearing due to the reported recurrence rate and late recurrences found in other retrospective reports [3,6,7,25,26]. Nevertheless, not all patients accept this recommendation which is shown in this study where 66% of the women with born children so far prefer to continue their clinical check ups.…”

Section: Discussionmentioning

confidence: 73%

See 1 more Smart Citation

Fertility-sparing surgery and outcome in fertile women with ovarian borderline tumors and epithelial invasive ovarian cancer

Borgfeldt

Iosif

Måsbäck

2007

European Journal of Obstetrics & Gynecology and Reproductiv

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Results: During the follow-up period of median 92 months, range 11-185 months, no relapse was found in the patients with stage Ia tumors including both the borderline tumors (n=12) and the invasive well (n=9) and moderately (n=1) differentiated ovarian cancers. One patient with poorly differentiated ovarian cancer stage 1c was pregnant at 13 weeks at the primary operation.Although, unilateral oophorectomy was performed she insisted in continuing the pregnancy. At 37 weeks she had a caesarian section and the ovarian cancer was disseminated. Chemotherapy was given but she died less than a year later. No other patient received chemotherapy. In total 30 children was born by 15 patients. Prophylactic removal of the remaining ovary +/-hysterectomy was accepted only in six of the women after completing their desire to have more children. However, several of these patients do not accept the recommendation of prophylactic oophorectomy of the contra lateral ovary and hysterectomy after completion of childbearing age. Conclusions4

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 73%

Fertility-sparing surgery and outcome in fertile women with ovarian borderline tumors and epithelial invasive ovarian cancer

Borgfeldt

Iosif

Måsbäck

2007

European Journal of Obstetrics & Gynecology and Reproductiv

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“…For invasive early ovarian cancer, some reports have demonstrated that well selected patients can safely benefit from conservative treatment as well, if platinum-based adjuvant chemotherapy is administered when indicated (clear cell histotype, grading 2-3, FIGO stage more than Ia) (2,(28)(29)(30)(31). In addition, germ cell tumors are highly chemosensitive and occur in young women in whom fertility-sparing surgery should always be pursued.…”

mentioning

confidence: 99%

Laparoscopic fertility-sparing staging in unexpected early stage ovarian malignancies

Muzii

Palaia

Sansone

et al. 2009

Fertility and Sterility

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“…Previous studies have shown promising reproductive outcomes after chemotherapy for malignant disease (Morice et al, 2001;Schilder et al, 2002;Park et al, 2008). Maltaris et al (2006) reported 282 cases of early stage EOC patients under FSS.…”

Section: Effect Of Chemotherapy On Ovarian Function and Fertilitymentioning

confidence: 99%

Clinical outcomes of fertility-sparing treatments in young patients with epithelial ovarian carcinoma

Zhu

Liang

et al. 2011

J. Zhejiang Univ. Sci. B

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Abstract:Objective: To assess the clinical outcomes of fertility-sparing treatments in young patients with epithelial ovarian carcinoma (EOC). Methods: A retrospective study of young EOC inpatients (≤40 years old) was performed during January 1994 and December 2010 in eight institutions. Results: Data were analyzed from 94 patients treated with fertility-sparing surgery with a median follow-up time of 58.7 months. As histologic grade increased, overall survival (OS) and disease-free survival (DFS) of patients receiving fertility-sparing surgery declined. Neither staging surgery nor laparoscopy of early stage EOC with conservative surgery had a significant effect on OS or DFS. Normal menstruation recommenced after chemotherapy in 89% of the fertility-sparing group. Seventeen pregnancies among twelve patients were achieved by the end of the follow-ups. Conclusions: Fertility-sparing treatment for patients with EOC Stage I Grade 1 could be cautiously considered for young patients. The surgical procedure and surgical route might not significantly influence the prognosis. Standard chemotherapy is not likely to have an evident impact on ovarian function or fertility in young patients.

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Results of conservative treatment in epithelial ovarian carcinoma

Cited by 90 publications

References 32 publications

Fertility-sparing surgery and outcome in fertile women with ovarian borderline tumors and epithelial invasive ovarian cancer

Fertility-sparing surgery and outcome in fertile women with ovarian borderline tumors and epithelial invasive ovarian cancer

Laparoscopic fertility-sparing staging in unexpected early stage ovarian malignancies

Clinical outcomes of fertility-sparing treatments in young patients with epithelial ovarian carcinoma

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