Preservation by simple hypothermia

Marshall, Vernon

doi:10.1007/978-94-011-5422-2_13

Cited by 8 publications

(9 citation statements)

References 58 publications

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“…During CS, anaerobic metabolization of 1 mol glucose, however, only yields 2 mol ATP versus a maximum of 38 mol in aerobic glycolysis. Moreover, two lactic acid molecules are formed leading to acidosis (13,44).…”

Section: Energy and Acidosismentioning

confidence: 99%

Perspectives in Organ Preservation

2007

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Maintaining organ viability after donation until transplantation is critically important for optimal graft function and survival. To date, static cold storage is the most widely used form of preservation in every day clinical practice. Although simple and effective, it is questionable whether this method is able to prevent deterioration of organ quality in the present era with increasing numbers of organs retrieved from older, more marginal, and even non-heart-beating donors. This review describes principles involved in effective preservation and focuses on some basic components and methods of abdominal organ preservation in clinical and experimental transplantation. Concepts and developments to reduce ischemia related injury are discussed, including hypothermic machine perfusion. Despite the fact that hypothermic machine perfusion might be superior to static cold storage preservation, organs are still exposed to hypothermia induced damage. Therefore, recently some groups have pointed at the beneficial effects of normothermic machine perfusion as a new perspective in organ preservation and transplantation.

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Section: Energy and Acidosismentioning

confidence: 99%

Perspectives in Organ Preservation

2007

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“…Hypothermic storage of kidneys remains the major approach to human kidney preservation because low temperature decreases metabolism of preserved organs [4]. Although University of Wisconsin (UW) solution was introduced to decrease ischemic graft damage [5], the beneficial effects of storage in this solution do not completely prevent cellular and interstitial swelling and reperfusion-induced oedema.…”

Section: Introductionmentioning

confidence: 99%

“…Although many grafted kidneys are lost because of immune-mediated mechanisms, there is clear evidence that non-immune factors, such as ischemia-reperfusion injury, contribute to short-term and long-term graft dysfunction [1,2,3].Hypothermic storage of kidneys remains the major approach to human kidney preservation because low temperature decreases metabolism of preserved organs [4]. Although University of Wisconsin (UW) solution was introduced to decrease ischemic graft damage [5], the beneficial effects of storage in this solution do not completely prevent cellular and interstitial swelling and reperfusion-induced oedema.…”

mentioning

confidence: 99%

Effect of IGL-1, a new preservation solution, on kidney grafts (a pre-clinical study)

et al. 2005

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Ischemia-reperfusion injury conditions short-term and long-term graft function. The effects of the inversion of K+ and Na+ concentrations and substitution with polyethylene glycol for hydroxyethyl starch in University of Wisconsin (K-UW) solution were evaluated in isolated perfused rat kidneys and in autotransplanted pig kidneys. In the rat model kidneys were cold-stored for 24 h in K-UW or Na-UW or Na-PEG UW solutions (IGL-1 solution). Fractional sodium reabsorption and glomerular filtration rate was better in kidneys preserved in Na-UW and IGL-1 solution than those preserved in K-UW solution. In the pig model the left kidney was harvested and preserved in K-UW or IGL-1 solution for 24 h and then transplanted. In the autotransplanted pig model, kidneys preserved in IGL-1 solution showed a better function and a significant reduction of MHC class II expression, cellular apoptosis and interstitial fibrosis. In conclusion, kidneys preserved in IGL-1 solution tolerated ischemia/reperfusion injury better than those preserved in K-UW solution.

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Section: Introductionmentioning

confidence: 99%

Effect of IGL-1, a new preservation solution, on kidney grafts (a pre-clinical study)

et al. 2004

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Ischemia-reperfusion injury conditions short-term and longterm graft function. The effects of the inversion of K + and N a + concentrations and substitution with polyethylene glycol for hydroxyethyl starch in University of Wisconsin (K-UW) solution were evaluated in isolated perfused rat kidneys and in autotransplanted pig kidneys. In the rat model kidneys were cold-stored for 24 h in K-UW or Na-UW or Na-PEG UW solutions (IGL-I solution). Fractional sodium reabsorption and glomerular filtration rate was better in kidneys preserved in Na-UW and IGL-1 solution than those preserved in K-UW solution. In the pig model the left kidney was harvested and preserved in K-UW or IGL-1 solution for 24 h and then transplanted. In the autotransplanted pig model, kidneys preserved in IGL-1 solution showed a better function and a significant reduction of MHC class I1 expression, cellular apoptosis and interstitial fibrosis.In conclusion, kidneys preserved in IGL-I solution tolerated ischemia/ reperfusion injury better than those preserved in K-UW solution.

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Preservation by simple hypothermia

Cited by 8 publications

References 58 publications

Perspectives in Organ Preservation

Perspectives in Organ Preservation

Effect of IGL-1, a new preservation solution, on kidney grafts (a pre-clinical study)

Effect of IGL-1, a new preservation solution, on kidney grafts (a pre-clinical study)

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