Presenting symptoms of epithelial ovarian cancer

Lataifeh, Isam; Marsden, Donald E.; Robertson, Greg; Gebski, Val; Hacker, Neville F.

doi:10.1111/j.1479-828x.2005.00391.x

Cited by 50 publications

(60 citation statements)

References 13 publications

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“…There have been several studies refuting the suggestion that delay in diagnosis is responsible for the advanced disease. 2,13,17,18 In these studies, women with early stage disease reported similar or rather longer duration of symptoms, indicating there may be significant biological differences between the early and advanced stages. Nevertheless, Goff's symptom index is meaningful in that it made patients and clinicians aware of specific symptoms as early alarm.…”

Section: 10mentioning

confidence: 86%

A hospital-based case-control study of identifying ovarian cancer using symptom index

Kim

et al. 2009

J Gynecol Oncol

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Objective: Recently, a symptom index for identification of ovarian cancer, based on specific symptoms along with their frequency and duration, was proposed. The current study aimed at validation of this index in Korean population. Methods: A case-control study of 116 women with epithelial ovarian cancer and 209 control women was conducted using questionnaires on eight symptoms. These included pelvic/abdominal pain, urinary urgency/frequency, increased abdominal size/bloating, difficulty eating/feeling full. The symptom index was considered positive if any of the 8 symptoms present for ＜1 year that occurred＞12 times per month. The symptoms were compared between ovarian cancer group and control group using chi-square test. Logistic regression analysis was used to determine whether the index predicted cancer. Sensitivity and specificity of the symptom index were also determined. Results: The symptom index was positive in 65.5% of women with ovarian cancer, in 31.1% of women with benign cysts, and in 6.7% of women on routine screening (ps＜0.001). Significantly higher proportion of ovarian cancer patients were positive for each symptom as compared with control group (ps＜0.001). Results from the logistic regression indicated that the symptom index independently predicted cancer (p＜0.001; OR, 10.51; 95% CI, 6.14 to 17.98). Overall, the sensitivity and specificity of the symptom index were 65.5% and 84.7%, respectively. Analyses of sensitivity by stage showed that the index was positive in 44.8% of patients with stage I/II disease and in 72.9% of patients with stage III/IV disease. Conclusion: The current study supported previous studies suggesting that specific symptoms were useful in identifying women with ovarian cancer.

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Section: 10mentioning

confidence: 86%

A hospital-based case-control study of identifying ovarian cancer using symptom index

Kim

et al. 2009

J Gynecol Oncol

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“…The symptoms are often very insidious and the duration of symptoms not very different between patients with early stage or advanced stage disease [13,14]. This may reflect the different biological behavior of the various histological subtypes; for example, grade 1 serous, clear cell, mucinous, and endometrioid cancers are commonly early stage at presentation, whereas high-grade serous cancers are most often Stage III because of early dissemination by a more aggressive cancer.…”

Section: Diagnosismentioning

confidence: 99%

“…Presenting symptoms include vague abdominal pain or discomfort, menstrual irregularities, and dyspepsia and other mild digestive disturbances, which may have been present for only a few weeks [13,14,43]. As the disease progresses, abdominal distention and discomfort from ascites generally worsen, and may be associated with respiratory symptoms from increased intra-abdominal pressure or from the transudation of fluid into the pleural cavities.…”

Section: Diagnosismentioning

confidence: 99%

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Cancer of the ovary, fallopian tube, and peritoneum

Berek

Crum

Friedlander

2015

Intl J Gynecology & Obste

123

119

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“…3 Izostanak simptomatologije u početnim stadijumima razvoja ovih tumora dovodi do toga da se dijagnoza bolesti postavlja relativno kasno, često tek kada se tumor nađe u uznapredovalom stadijumu, što posebnu važnost daje preciznom utvrđivanju patohistoloških prognostičkih faktora neoplazme. 4,5 Tu se pre svega misli na proliferativni potencijal tumora, izmenu sekrecije mucina i očuvanost transporta sekretornog imunoglobulina A. Proliferativna aktivnost neoplazmi je jedna od njihovih najvažnijih prognostičkih karakteristika. Danas je standard za procenu ove aktivnosti upotreba markera proliferacije poput Ki-67 koji, kada su u pitanju ovarijalni tumori prema Wang-u i sar.…”

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Histochemical characterization of epithelial ovarian cancer

Milosavljević¹,

Andelković²,

Nikolić³

2014

PONS

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Histochemical characterization of epithelial ovarian cancer 3 3KORESPONDENCIJA / CORRESPONDENCE strana / page 3Cilj. Cilj našeg istraživanja je bilo određivanje prognostičke važnosti izmene sekrecije mucina i ekspresije Ki-67 antigena i IgA u tkivu tumora jajnika.Metode. Tumorsko tkivo jajnika 42 pacijentkinje je histološki obrađivano i bojeno uz pomoć mucinohistohemijskih i imunocitohemijskih metoda.Rezultati. Na našem materijalu marker proliferacije ćelija se pokazao kao validan prognostički faktor stepena atipije tumorskih ćelija. Imunoglobulin A je veri kovan u značajnoj meri u epitelu i sekretu kod benignih formi, a znatno manje kod malignih formi ovarijalnih neoplazmi. Histohemijska analiza mucina pokazala je izmenu od neutralih do kiselih kako stepen malignosti tumora raste. Istovremeno u poljima anaplazije mucini nedostaju.Zaključak. Marker proliferacije Ki-67, IgA i izmena sekrecije mucina su validni prognostički faktori kod ovarijalnih neoplazmi.Ključne reči: Ki-67 antigen; imunoglobulin A; mucini; jajnik.Objective. Study was designed to reveal the prognostic significance of Ki-67, IgA and mucin secretion in ovarian neoplasms.Methods. Samples of ovarian tumours of 42 female patients were routinely processed and stained with anti-Ki67 and antiIgA antibodies as well as with histochemistry methods for mucin verification.Results. In our study proliferation marker Ki-67 was proven to be a good prognostic tool of the degree of the cellular atypia. High immunoglobulin A expression was verified in the epithelium and along the luminal border of well differentiated tumors. Histochemical mucin analysis showed quantitative and qualitative changes in mucin secretion that correlates with the degree of tumor differentiation.Conclusion. Ki-67, IgA and epithelial mucins are valid prognostic factors in ovarian neoplasms.

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Presenting symptoms of epithelial ovarian cancer

Abstract: Patients with early stage ovarian cancer are likely to be younger and to have larger, better differentiated tumours that are more often non-serous histologically. Advanced disease is not invariably due to delayed diagnosis.

Cited by 50 publications

References 13 publications

A hospital-based case-control study of identifying ovarian cancer using symptom index

A hospital-based case-control study of identifying ovarian cancer using symptom index

Cancer of the ovary, fallopian tube, and peritoneum

Histochemical characterization of epithelial ovarian cancer

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