A multicentre, double-blind, randomized study was performed in 179 patients with acute ischaemic stroke resulting in limb paresis. The purpose was to compare the safety and efficacy of Org 10172 (1250 anti-Xa Units s.c. once daily) and heparin sodium (5000 IU s.c. twice daily) in preventing deep-vein thrombosis (DVT). Prophylaxis started within 72 hours of the onset of stroke and continued for at least 9 days. To detect DVT, patients underwent a daily 125I-fibrinogen leg scanning which, if found positive, was followed by venography. A first computed tomography scan of the brain was performed at screening to rule out cerebral haemorrhage and a second at cessation of treatment to detect any haemorrhagic transformations. At the 2-3-months' follow-up period the patients were examined for signs and symptoms of DVT or pulmonary embolism. On an intention-to-treat analysis, DVT occurred in 14.6% of patients receiving Org 10172 and in 19.8% of those receiving heparin during the treatment period (p = 0.392, NS). Pulmonary embolism was diagnosed in one patient in each group. Major conversion to a symptomatic haemorrhagic brain infarct was found in one patient in each group. Death occurred in 13.5% of patients treated with Org 10172 and in 6.7% of patients treated with heparin (p = 0.135, NS). Deaths were mainly related to pulmonary infection and cerebral oedema, thus considered to be due directly to the clinical status of the patients. 1250 anti-Xa Units of Org 10172 once daily is both safe and as effective as 5000 IU of heparin sodium twice daily given for DVT prophylaxis in patients with acute ischaemic stroke of recent onset.
Vasospasm is the principal cause of a poor outcome in patients with SAH. The aim of the study is to establish the effect of the therapeutic modalities on vasospasm, to establish morbidity and mortality of patients with SAH, as well as the causes of the poor outcome. The study is prospective and analyzes 192 patients treated at C ward of the INH KCS. Vasospasm incidence was 22.40%. Therapeutic modalities depended on prescribed quantities of colloid solutions and MgSO4 solution. Differences in the vasospasm incidence between the groups were not significant, the reason probably being that the maximal doses of colloid solutions were prescribed mostly to the higher graded patients. In patients who received MgSO4 vasospasm was less frequent, but not statistically significant (11.11% vs. 23.56%) Of 192 patients, 78.1% completely recovered, 9.9% had a certain degree of invalidity, and 12.0% did not survive. The most frequent cause of death was vasospasm (41.67%) and then general medical complications (20.93%).
Histochemical characterization of epithelial ovarian cancer 3 3KORESPONDENCIJA / CORRESPONDENCE strana / page 3Cilj. Cilj našeg istraživanja je bilo određivanje prognostičke važnosti izmene sekrecije mucina i ekspresije Ki-67 antigena i IgA u tkivu tumora jajnika.Metode. Tumorsko tkivo jajnika 42 pacijentkinje je histološki obrađivano i bojeno uz pomoć mucinohistohemijskih i imunocitohemijskih metoda.Rezultati. Na našem materijalu marker proliferacije ćelija se pokazao kao validan prognostički faktor stepena atipije tumorskih ćelija. Imunoglobulin A je veri kovan u značajnoj meri u epitelu i sekretu kod benignih formi, a znatno manje kod malignih formi ovarijalnih neoplazmi. Histohemijska analiza mucina pokazala je izmenu od neutralih do kiselih kako stepen malignosti tumora raste. Istovremeno u poljima anaplazije mucini nedostaju.Zaključak. Marker proliferacije Ki-67, IgA i izmena sekrecije mucina su validni prognostički faktori kod ovarijalnih neoplazmi.Ključne reči: Ki-67 antigen; imunoglobulin A; mucini; jajnik.Objective. Study was designed to reveal the prognostic significance of Ki-67, IgA and mucin secretion in ovarian neoplasms.Methods. Samples of ovarian tumours of 42 female patients were routinely processed and stained with anti-Ki67 and antiIgA antibodies as well as with histochemistry methods for mucin verification.Results. In our study proliferation marker Ki-67 was proven to be a good prognostic tool of the degree of the cellular atypia. High immunoglobulin A expression was verified in the epithelium and along the luminal border of well differentiated tumors. Histochemical mucin analysis showed quantitative and qualitative changes in mucin secretion that correlates with the degree of tumor differentiation.Conclusion. Ki-67, IgA and epithelial mucins are valid prognostic factors in ovarian neoplasms.
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