Present trends in coeliac disease

Shiner, Margot

doi:10.1136/pgmj.60.709.773

Cited by 8 publications

(3 citation statements)

References 50 publications

(36 reference statements)

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“…These children, however, were younger than those with celiac disease; over two-thirds of them were under the age of 2 years. With the still prevailing practice, in this community, of early addition of cereals to infants' diet, ab sorption of gluten macromolecules may occur, particularly in malnourished children [20].…”

Section: Discussionmentioning

confidence: 99%

Antigliadin and Antireticulin Antibodies in Celiac Disease and Other Forms of Protracted Diarrhea in Kuwait

Khuffash

Alkarmi²,

Najdi

et al. 1994

Med Princ Pract

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Sera were collected from 18 children with celiac disease and 49 children with other forms of chronic diarrhea. Of the 49 children with other forms of chronic diarrhea, 35 had postenteritis, 8 had giardiasis and 6 had other diagnoses. Thirty children with nongastrointestinal disorders were tested and used as controls. The sera were tested for gliadin, α-gliadin and reticulin antibodies: false-positive values in children with other forms of chronic diarrhea were encountered in 27, 45, and 4% and in 3, 3, and 0% of controls, respectively. The sensitivity in celiac disease was 89,89 and 50%, while the specificity was 71 49 and 94%, respectively. In Kuwait, postenteritis syndromes are common causes of protracted diarrhea. Antibodies to gliadins are as sensitive but significantly less specific for celiac disease (CD) than those reported in developed countries. The combined testing of antigliadin and antireticulin antibodies raised the diagnostic specificity to 94%.

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Section: Discussionmentioning

confidence: 99%

Antigliadin and Antireticulin Antibodies in Celiac Disease and Other Forms of Protracted Diarrhea in Kuwait

Khuffash

Alkarmi²,

Najdi

et al. 1994

Med Princ Pract

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“…Another interesting phenomenon pertaining to the perceived clinical expression of CD began to appear in the 80s: on one side it became increasingly clear that CD may be associated with other conditions, mostly autoimmune disorders such as type 1 diabetes, but also some syndromes such as Down [35][36][37][38][39]; on the other side, it was obvious that CD was changing patterns of presentation, becoming less and less an intestinal disorder, and more and more a variety of extraintestinal symptoms and signs [40]. These facts, today well known, were described and immediately appreciated mostly in Europe, while in North America no one seemed to pay attention to them.…”

Section: Progress In Delineating the Clinical Spectrummentioning

confidence: 99%

Historical Perspective of Celiac Disease

Guandalini¹

2008

Frontiers in Celiac Disease

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“…Celiac disease is a form of malabsorption characterised by diarrhea, weight loss, abdominal distention, anemia and in children stunted growth. There is villous atrophy of the mucosa of the upper small intestine (1). The condition is due to intolerance to the gliadin fraction of dietary gluten found in wheat and rye flour.…”

mentioning

confidence: 99%

Salivary and serum antibodies to gliadin in the diagnosis of celiac disease

Aldred

Walker

et al. 1989

J Oral Pathology Medicine

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Salivary IgA and serum IgA and IgG antibodies to crude gliadin and alpha-gliadin were measured in adult patients with untreated celiac disease, ulcerative colitis, Crohn's disease and normal controls. Antibody levels in saliva and serum in untreated celiac disease were significantly higher than in other groups. Alpha-gliadin antibodies appeared to be a better discriminator for serum but not for saliva. The assay of salivary IgA antibodies to gliadin offers a non-invasive test which would be particularly useful in the investigation of celiac disease and for monitoring compliance with a gluten-free diet.

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Present trends in coeliac disease

Cited by 8 publications

References 50 publications

Antigliadin and Antireticulin Antibodies in Celiac Disease and Other Forms of Protracted Diarrhea in Kuwait

Antigliadin and Antireticulin Antibodies in Celiac Disease and Other Forms of Protracted Diarrhea in Kuwait

Historical Perspective of Celiac Disease

Salivary and serum antibodies to gliadin in the diagnosis of celiac disease

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