Present Status of Adenine Nucleotides in Bodily Response to Injury

Abstract

RHEUMATOID ARTHRITIS BRITISII 805 .~~~~~~~~~~~~~~~~~~~~~~~~~MEDICAL JOURNAL opportunity was taken of investigating the clinical pattern of the disease.In contrast to the clinical pattern of the disease, which was found to be in keeping with the standard textbook description, the investigation into alleged aetiological factors produced largely negative results. Most factors investigated were found to occur as often in controls as in patients.Information was obtained which suggests that further study is warranted into the influence of the familial factor, the effects of cold and damp and climate, abnormalities of the peripheral circulation, and the relation of pregnancy and the menopause to the aetiology of rheumatoid arthritis.

Purinoceptor mediated stimulation of prostacyclin release in the porcine pulmonary vasculature

“…The concentrations of ATP and ADP that stimulate pulmonary prostacyclin production are similar to those shown to be vasoactive (Burnstock, 1981;Gordon & Martin, 1983a). The concept that extracellular purines could be biologically active arose in the late 1940s when it was discovered that following acute trauma, ATP was released into the circulation and caused extensive peripheral vasodilatation (Green & Stoner, 1950). This concept has since gained much support and it is clear that cell death is not necessary for the release of ATP.…”

“…Extracellular adenosine 5'-triphosphate (ATP) is a powerful vasoactive agent (Green & Stoner, 1950; 1 Present address: Section of Vascular Biology, MRC Clinical Research Centre, Harrow, Middlesex HAl 3UJ. t Correspondence.…”

Pharmacological Nature of the Purinergic P2Y Receptor Subtypes That Participate in the Blood Pressure Changes Produced by ADPβS in Rats

“…Once released, ATP is rapidly hydrolysed/dephosphorylated by several families of ectonucleotidases to adenosine 5diphosphate (ADP), adenosine 5 -monophosphate (AMP), and adenosine [13]. These dephosphorylated metabolites, and ATP itself, were reported in 1950 to produce diverse cardiovascular effects (including coronary vasodilatation) in several species [14].…”