Presence of type III collagen in disc attachments of human temporomandibular joints

Gage, J. P.; Virdi, Amarjit S.; Triffitt, James T.; Howlett, C. R.; Francis, M. J. O.

doi:10.1016/0003-9969(90)90044-b

Cited by 45 publications

(32 citation statements)

References 18 publications

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“…The collagen fibrils are organized in a cross-linked network that has high resistance to stretch and tensile forces along the long axes of the fibers and flexibility in other orientations (Mills et al, 1988;Mow et al, 1992). However, unlike hya-line cartilage, in which the major collagen species is type II collagen synthesized by chondrocytes, the major collagen species of fibrocartilage is type I collagen, primarily formed by fibroblast-like cells (Grinnell and Lamke, 1984;Milam et al, 1991b,c ; Kobayashi, 1992;Gage et al, 1990;Haskin, 1995).…”

Section: (A) the Temporomandibular Joint Has Unique Featuresmentioning

confidence: 99%

Pathogenesis of Degenerative Joint Disease in the Human Temporomandibular Joint

Haskin

Milam²,

Cameron

1995

Critical Reviews in Oral Biology & Medicine

136

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ABSTRACT:The wide range of disease prevalences reported in epidemiological studies of temporomandibular degenerative joint disease reflects the fact that diagnoses are frequently guided by the presence or absence of non-specific signs and symptoms. Treatment is aimed at alleviating the disease symptoms rather than being guided by an understanding of the underlying disease processes. Much of our current understanding of disease processes in the temporomandibular joint is based on the study of other articular joints. Although it is likely that the molecular basis of pathogenesis is similar to that of other joints, additional study of the temporomandibular joint is required due to its unique structure and function. This review summarizes the unique structural and molecular features of the temporomandibular joint and the epidemiology of degenerative temporomandibular joint disease. As is discussed in this review, recent research has provided a better understanding of the molecular basis of degenerative joint disease processes, including insights into: the regulation of cytokine expression and activation, arachidonic acid metabolism, neural contributions to inflammation, mechanisms of extracellular matrix degradation, modulation of cell adhesion in inflammatory states, and the roles of free radicals and heat shock proteins in degenerative joint disease. Finally, the multiple cellular and molecular mechanisms involved in disease initiation and progression, along with factors that may modify the adaptive capacity of the joint, are presented as the basis for the rational design of new and more effective therapy.

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Section: (A) the Temporomandibular Joint Has Unique Featuresmentioning

confidence: 99%

Pathogenesis of Degenerative Joint Disease in the Human Temporomandibular Joint

Haskin

Milam²,

Cameron

1995

Critical Reviews in Oral Biology & Medicine

136

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“…The TMJ disc contains a variety of ECM components, such as collagens, proteoglycans and related glycosaminoglycans [2,4,14,16,17,20,28]. Types II and IX collagen, which are characteristic components of cartilage, were found in bovine TMJ disc [17].…”

Section: Discussionmentioning

confidence: 99%

“…Although the pathogenesis for TMJ diseases is not fully understood, it is assumed that irreversible elongation with loosening of the posterior attachment is a critical phenomenon in TMJ diseases [3,27,30]. Gage et al [4] suggested that a higher ratio of type III collagen in the posterior attachment increases tissue fragility and results in displacement of the TMJ disc. Further investigation of the localization of collagens in the TMJ disc and their relationship to TMJ disorders is necessary to understand the exact pathogenesis of TMJ diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Collagens and proteoglycans (PG)s are prominent extracellular matrix (ECM) components in the TMJ [2,4,8,10,14,16,17,22,23,29,33]. Over 10 genetically and structurally distinct types of collagen have been found in various connective tissues, and these can be divided into two different subgroups, i.e., fibrillar and FACIT (fibril-associated collagen with interrupted triple helices) [15].…”

Section: Introductionmentioning

confidence: 99%

“…Other collagens belong to the second group, and consist of several shorter triple-helical domains separated by nontriple-helical domains. The fibrillar collagens form fibrils, which give tissues mechanical integrity [4,6,11] and provide a proper environment for cellular differentiation [25].…”

Section: Introductionmentioning

confidence: 99%

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An Immunohistochemical Study of the Localization of Types I, II and III Collagen in the Temporomandibular Joint of Growing Monkeys.

Hamaya

Takahashi

Sasano

et al. 2001

Acta Histochem. Cytochem

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We sought to immunohistochemically localize types I, II and III collagen in various regions of the temporomandibular joint (TMJ) in two female rhesus monkeys at different growth stages: juvenile and late-adolescence. In the condylar cartilage, staining for types I and III collagen was weak in the fibrous layer, intense in the pre-cartilaginous layer, and faint in the cartilaginous layer, whereas that for type II collagen was limited to the cartilaginous layer. The glenoid fossa showed moderate staining for type I collagen and weak staining for type II collagen, indicating that this tissue consists of chondroid bone, which is an intermediary between bone and cartilage. TMJ discs showed more intense staining for types I and III collagen in their periphery than in their centers. Staining for type II collagen was not detected throughout the disc. The posterior attachments showed rather weak staining for type I collagen and relatively intense staining for type III collagen. These results suggest that there are regional differences in the phenotypic expression of the three major collagen components in the growing monkey TMJ, which probably provide specific biomechanical resistance.

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Temporomandibular Joint Disc

Allen

Detamore

Almarza

et al. 2006

Wiley Encyclopedia of Biomedical Engineering

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The temporomandibular joint (TMJ) is a ginglymo‐diarthrodial synovial joint. Its principal components are the fossa‐eminence of temporal bone, the mandibular condyle, and a fibrocartilagenous articular disc known as the TMJ disc. TMJ movements are more complex than most synovial joints. The TMJ disc plays a key role in these movements by distributing load, absorbing shock, and lubricating surfaces. The extracellular matrix (ECM) of the TMJ disc is primarily composed of collagen type I, which forms a ring‐like structure around the periphery of the disc and in the anteroposterior direction in the intermediate zone. Glycosaminoglycans, proteoglycans, and elastin fibers also form the ECM. The cell types of the disc include a nonhomogeneous distribution of fibroblasts and chondrocyte‐like cells; these cells serve to maintain the ECM of the TMJ disc. The mechanical properties of the disc are mostly unknown because of large variations between animal models and test methodologies; however, it is believed that the TMJ disc is primarily a tensile tissue. Several disorders, including internal derangements, degenerative diseases, and reparative/osteogenic diseases, are associated with an injured or displaced disc. These disorders affect about 2–4% of the population and greatly reduce the quality of a patient's life, afflicting everyday activities such as eating, talking, and laughing. Treatments for severe temporomandibular dysfunction are available, but alleviation of joint problems without future repercussions is difficult. Biomedical engineering continues to work toward better solutions for temporomandibular dysfunction by developing innovative treatments and fully characterizing the components and diseases of the TMJ.

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Presence of type III collagen in disc attachments of human temporomandibular joints

Cited by 45 publications

References 18 publications

Pathogenesis of Degenerative Joint Disease in the Human Temporomandibular Joint

Pathogenesis of Degenerative Joint Disease in the Human Temporomandibular Joint

An Immunohistochemical Study of the Localization of Types I, II and III Collagen in the Temporomandibular Joint of Growing Monkeys.

Temporomandibular Joint Disc

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