Presence of the variant mannose-binding lectin alleles associated with slower progression to AIDS

Maas, Jolanda; Husman, Ana Maria de Roda; Brouwer, Margreet; Krol, Anneke; Coutinho, Roel A.; Keet, I. P. M.; Leeuwen, R. van; Schuitemaker, Hanneke

doi:10.1097/00002030-199817000-00008

Cited by 62 publications

(29 citation statements)

References 21 publications

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“…This is further supported by the finding that HIV-1-infected men with variant MBL alleles (95% of whom were heterozygote) progressed more slowly to AIDS and death. 26 We previously reported that the variant MBL alleles, mainly in the heterozygous state, are prevalent in patients with sickle cell anemia who had not suffered severe infections. 27 Similarly, other studies have demonstrated that heterozygotes are protected against tuberculosis infection.…”

Section: Mbl Genotypes and Infectionsmentioning

confidence: 98%

Mannose-binding lectin alleles in sub-Saharan Africans and relation with susceptibility to infections

Mombo

Ossari

et al. 2003

Genes Immun

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Mannose-binding lectin (MBL) plays an important role in the early stages of primary infections and during the decay of maternal antibodies in infants. Various studies have looked at the relation between serum MBL concentrations, MBL gene alterations and susceptibility to infections. We investigated the distribution of variant MBL alleles in 626 unrelated adults from sub-Saharan African countries and looked for a potential relation between these alleles and the incidence, prevalence and death rate of tuberculosis for sub-Saharan Africa. We also evaluated the relation between MBL genotypes and susceptibility to HIV-1 infection in 188 Gabonese adults. We found that (i) the prevalence of the common variant MBL alleles is correlated with the incidence of tuberculosis in sub-Saharan Africa (r ¼ 0.565), (ii) the mutant MBL G57E allele, in either the homozygous or compound heterozygous state, is associated with susceptibility to HIV-1 infection in the Gabonese population (P ¼ 0.019).Our data plus those in the literature suggest that individuals who are homozygous for the mutant MBL alleles display increased susceptibility to infections. Interestingly, we found that individuals who are heterozygous for MBL mutations are much less susceptible to infections than those who are homozygous for the wild-type MBL allele.

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Section: Mbl Genotypes and Infectionsmentioning

confidence: 98%

Mannose-binding lectin alleles in sub-Saharan Africans and relation with susceptibility to infections

Mombo

Ossari

et al. 2003

Genes Immun

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“…Elevated MBL serum levels correlate with better survival in patients with AIDS and homozygosity for MBL variant alleles B, C and D have been associated with lower MBL serum levels and an increased susceptibility to HIV-1 infection Piacentini et al, 2009). Studies that have looked at the effects of MBL genotype on the clinical outcome of HIV-1 infection in therapy-naïve subjects were unable to make a definitive correlation between MBL genotype (homozygous versus WT for MBL variants) and HIV-1 disease non-progression Maas et al, 1998). For instance, in a cohort study of HIV-infected homosexual seroconverters (n596) who were followed for 10 years, the correlation between MBL genotype and the time to AIDS was not statistically significant (P50.8).…”

Section: Innate Immunitymentioning

confidence: 99%

Human immunodeficiency virus type 1 long-term non-progressors: the viral, genetic and immunological basis for disease non-progression

Poropatich

Sullivan

2010

Journal of General Virology

144

119

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“…Tel. : +98 411 3357126, Fax: +98 411 3364666. acetylglucosamine and activates the complement system independently of antibodies via two associated serin protease, mannose binding lectin-associated serine protease 1 and 2 (Jack et al, 2001;Mass et al, 1998;Thiel et al, 1997). C1q and mannose binding lectin, as well as lung surfactant protein A, share the same phagocytic receptor, which is present on a variety of cells, including phagocytes, platelets, and endothelial cells (Nepomuceno et al, 1999;Nepomuceno et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Comparing mannose binding lectin genetic diversity in intracellular and extracellular pathogens

Asgharzadeh¹,

Kafil²

2007

Afr. J. Biotechnol.

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One of the important immunological factors in diseases is mannose binding lectin (MBL).The aim of present study is to determine the distribution of the alleles of mannose-binding lectin gene codon 52, 54, 57 and promoter variants H/L, X/Y, P and Q in confirmed VL patients as an intracellular pathogen while compares with extracellular pathogens (in renal infection) and seek correlation between these variants and intracellular and extracellular infections. Fifty eight confirmed VL patients' blood samples were compared with fifty eight blood samples of patients received renal in results of renal infections. MBL genotypes were investigated by polymerase chain reaction and restriction fragment length polymorphism. Frequency of defective allele B in extracellular pathogens was more than intracellular pathogens (P = 0.0001), and in contrary prevalence of wild type allele A in intracellular pathogens was more than extracellular pathogens (P = 0.0001), and in other alleles and variants there was not any significant difference. In conclusion, there was more prevalence of alleles with low mannose binding lectin serum level in extrallelular pathogens which can be consider as a risk factor for these infections. In other hand prevalence of high concentration alleles in intracellular pathogens indicate the role of mannose binding lectin level for susceptibility to intracellular pathogens.

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Presence of the variant mannose-binding lectin alleles associated with slower progression to AIDS

Abstract: Indications for a weak pre-AIDS protective effect of variant MBL alleles were demonstrated.

Cited by 62 publications

References 21 publications

Mannose-binding lectin alleles in sub-Saharan Africans and relation with susceptibility to infections

Mannose-binding lectin alleles in sub-Saharan Africans and relation with susceptibility to infections

Human immunodeficiency virus type 1 long-term non-progressors: the viral, genetic and immunological basis for disease non-progression

Comparing mannose binding lectin genetic diversity in intracellular and extracellular pathogens

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