Presence of the father and parental experience have differentiated effects on pup development in Mongolian gerbils (Meriones unguiculatus)

Piovanotti, Marcelo Richar Arua; Vieira, Mauro Luı́s

doi:10.1016/j.beproc.2004.01.007

Cited by 24 publications

(13 citation statements)

References 31 publications

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“…These studies have revealed extensive, often sex-specific effects on offspring, including effects on survival, especially under adverse conditions (Cantoni and Brown, 1997; Gubernick et al, 1993; Wright and Brown, 2002), developmental markers (Elwood and Broom, 1978; Piovanotti and Vieira, 2004; Wang and Novak, 1992), and behavior (Ahern et al, 2010; Ahern and Young, 2009; Bredy et al, 2004). …”

Section: Effects Of Male Parenting On Offspringmentioning

confidence: 99%

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Fathering in rodents: Neurobiological substrates and consequences for offspring

Bales

Saltzman

2016

Hormones and Behavior

125

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Paternal care, though rare among mammals, is routinely displayed by several species of rodents. Here we review the neuroanatomical and hormonal bases of paternal behavior, as well as the behavioral and neuroendocrine consequences of paternal behavior for offspring. Fathering behavior is subserved by many of the same neural substrates which are also involved in maternal behavior (for example, the medial preoptic area of the hypothalamus). While gonadal hormones such as testosterone, estrogen, and progesterone, as well as hypothalamic neuropeptides such as oxytocin and vasopressin, and the pituitary hormone prolactin, are implicated in the activation of paternal behavior, there are significant gaps in our knowledge of their actions, as well as pronounced differences between species. Removal of the father in biparental species has long-lasting effects on behavior, as well as on these same neuroendocrine systems, in offspring. Finally, individual differences in paternal behavior can have similarly long-lasting, if more subtle, effects on offspring behavior. Future studies should examine similar outcome measures in multiple species, including both biparental species and closely related uniparental species. Careful phylogenetic analyses of the neuroendocrine systems presumably important to male parenting, as well as their patterns of gene expression, will also be important in establishing the next generation of hypotheses regarding the regulation of male parenting behavior.

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Section: Effects Of Male Parenting On Offspringmentioning

confidence: 99%

“…Another aspect of paternal experience that might affect offspring development is previous experience as a father (as opposed to alloparenting experience). Offspring of experienced Mongolian gerbil fathers locomote more outside the nest than offspring of inexperienced fathers (Piovanotti and Vieira, 2004). …”

Section: Effects Of Male Parenting On Offspringmentioning

confidence: 99%

Fathering in rodents: Neurobiological substrates and consequences for offspring

Bales

Saltzman

2016

Hormones and Behavior

125

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“…Paternal behavior has been reported in several nonhuman monogamous mammalian species including tamarins [246], marmosets [5], titis [160, 161], hamsters [118], gerbils [182], mice [24] and voles [174, 205]. Studies in nonhuman primates have focused on the characterization of paternal behaviors and the effects that manipulations of the social environment have on the display of these behaviors, and have provided important translational information for human health.…”

Section: Neurobiology Of Paternal Behaviormentioning

confidence: 99%

The neurobiology of pair bonding: Insights from a socially monogamous rodent

Young

Gobrogge

Yan

et al. 2011

Frontiers in Neuroendocrinology

314

286

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The formation of enduring relationships between adult mates (i.e., pair bonds) is an integral aspect of human social behavior and has been implicated in both physical and psychological health. However, due to the inherent complexity of these bonds and the relative rarity with which they are formed in other mammalian species, we know surprisingly little about their underlying neurobiology. Over the past few decades, the prairie vole (Microtus ochrogaster) has emerged as an animal model of pair bonding. Research in this socially monogamous rodent has provided valuable insights into the neurobiological mechanisms that regulate pair bonding behaviors. Here, we review these studies and discuss the neural regulation of three behaviors inherent to pair bonding: the formation of partner preferences, the subsequent development of selective aggression toward unfamiliar conspecifics, and the bi-parental care of young. We focus on the role of vasopressin, oxytocin, and dopamine in the regulation of these behaviors, but also discuss the involvement of other neuropeptides, neurotransmitters, and hormones. These studies may not only contribute to the understanding of pair bonding in our own species, but may also offer insight into the underlying causes of social deficits noted in several mental health disorders.

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“…In some social rodents, fathers play an important role in offspring development, and paternal care, like maternal care, remarkably alters social behaviors and emotional functions such as physical growth [4,5,6,7], juvenile play/fighting [8], aggressive behavior [9], social recognition [10] and cognitive development [11], anxiety levels and sociability [12,13], pair bonding [14] and parental behavior in adulthood [12,13]. Paternal deprivation (PD) produces significant changes in the related neural substrate and it is thought that alterations in behavior are associated with depressed arginine vasopressin levels in the anterior hypothalamus [8], less oxytocin receptor mRNA expression in the nucleus accumbens (NAcc) [10], altered mRNA expression of dopamine-1-type receptor (D1R) and D2R in the NAcc [14], increased OT content and greater dorsal raphe corticotrophin-releasing factor (CRF)-2 densities [15] and reduction of estrogen receptor-α expression in the bed nucleus of the stria terminalis (BNST), medial preoptic area, ventromedial nucleus of hypothalamus and arcuate hypothalamic nucleus [13].…”

Section: Introductionmentioning

confidence: 99%

Early Paternal Deprivation Alters Levels of Hippocampal Brain-Derived Neurotrophic Factor and Glucocorticoid Receptor and Serum Corticosterone and Adrenocorticotropin in a Sex-Specific Way in Socially Monogamous Mandarin Voles

Song²,

Wang³

et al. 2014

Neuroendocrinology

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In monogamous mammals, fathers play an important role in the development of the brain and typical behavior in offspring, but the exact nature of this process is not well understood. In particular, little research has addressed whether the presence or absence of paternal care alters levels of hippocampal glucocorticoid receptor (GR) and brain-derived neurotrophic factor (BDNF), and basal levels of serum corticosterone (CORT) and adrenocorticotropin (ACTH). Here, we explored this concept using socially monogamous mandarin voles (Microtus mandarinus), a species in which fathers display high levels of paternal care toward their pups. Our immunohistochemical study shows that paternal deprivation (PD) significantly decreased levels of GR and BDNF protein in the CA1 and CA2/3 of the hippocampus. In the dental gyrus, decreases in GR and BDNF induced by PD were evident in females but not in males. Additionally, enzyme-linked immunosorbent assay results show that PD significantly upregulated levels of serum CORT and ACTH in females, but not males. These findings demonstrate that PD alters HPA axis activity in a sex-specific way. The changes in stress hormones documented here may be associated with alteration in hippocampal BDNF and GR levels.

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Presence of the father and parental experience have differentiated effects on pup development in Mongolian gerbils (Meriones unguiculatus)

Cited by 24 publications

References 31 publications

Fathering in rodents: Neurobiological substrates and consequences for offspring

Fathering in rodents: Neurobiological substrates and consequences for offspring

The neurobiology of pair bonding: Insights from a socially monogamous rodent

Early Paternal Deprivation Alters Levels of Hippocampal Brain-Derived Neurotrophic Factor and Glucocorticoid Receptor and Serum Corticosterone and Adrenocorticotropin in a Sex-Specific Way in Socially Monogamous Mandarin Voles

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