Presence of sensory nerve corpuscles in the human corpus and cervix uteri during pregnancy and labor as revealed by immunohistochemistry

Tingåker, Berith K; Ekman-Ordeberg, Gunvor; Forsgren, Sture

doi:10.1186/1477-7827-4-45

Cited by 14 publications

(6 citation statements)

References 33 publications

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“…Apart from humoral mechanisms, the endogenous analgesia during pregnancy might have an anatomical basis. Indeed, previous studies report that the corpus uteri undergoes an almost complete nerve fibre lost during late pregnancy and labour, in spite of a still preserved cervix innervation (Bryman et al., ; Lundberg et al., ; Morizaki et al., ; Tingaker et al., ,b). Interestingly, Tingaker demonstrated a strong TRPV1 (capsaicin receptor) positive nerve fibre reduction in the corpus uteri during pregnancy and labour (Tingaker et al., ).…”

Section: Discussionmentioning

confidence: 99%

Pregnancy‐induced analgesia: a combined psychophysical and neurophysiological study

Draisci

Catarci

Vollono

et al. 2012

European Journal of Pain

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Section: Discussionmentioning

confidence: 99%

Pregnancy‐induced analgesia: a combined psychophysical and neurophysiological study

Draisci

Catarci

Vollono

et al. 2012

European Journal of Pain

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“…Previous studies have shown a significant increase of TRPV1-IR nerve fibers in inflammatory conditions that elicit pain, such as painful bladder syndrome [ 18 ] and vulvodynia [ 17 ], and are believed to involve NGF. We have, in an earlier study, demonstrated the occurrence of the NGF receptor p75 in human corpus and cervix uteri in pregnancy and labor [ 36 ] and have unpublished data showing mRNA expression for NGFβ and its specific receptor Trk A in biopsies from human corpus and cervix uteri in term pregnancy and labor. Studies in other laboratories have also established links between NGF and TRPV1 where increased TRPV1 levels in peripheral nociceptor terminals are generally restricted to TrkA bearing terminals in inflamed tissue due to NGF mediated activation of p38 MAPK system [ 13 , 29 , 35 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

Influence of pregnancy and labor on the occurrence of nerve fibers expressing the capsaicin receptor TRPV1 in human corpus and cervix uteri

Tingåker

Ekman-Ordeberg

Facer

et al. 2008

Reprod Biol Endocrinol

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Background: Cervical ripening is a prerequisite for a normal obstetrical outcome. This process, including labor, is a painful event that shares features with inflammatory reactions where peripheral nociceptive pathways are involved. The capsaicin and heat receptor TRPV1 is a key molecule in sensory nerves involved in peripheral nociception, but little is known regarding its role in the pregnant uterus. Therefore, the aim of this study was to investigate human corpus and cervix uteri during pregnancy and labor and non-pregnant controls for the presence of TRPV1.

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“…This finding contrasts previous work by Owman et al (1967), using different markers of innervation, who reported no sympathetic nerves within the endometrium. Tingaker et al (2006) examined the presence of sensory corpuscles in non-pregnant women, pregnant women, and women in labor.…”

Section: Cervix Innervation Determined Via Specific Neuronal Markersmentioning

confidence: 99%

The human cervix: Comprehensive review of innervation and clinical significance

et al. 2022

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Detailed knowledge regarding the innervation and histology of the human cervix is crucial given the surgical removal of this tissue for conditions such as cervical dysplasia. Recent evidence implicates the cervix in the sexual response, making it pertinent to characterize this region to elucidate its role. Despite this, literature describing the overall innervation of the cervix from anatomical and histological perspectives is lacking. The aim of this review was to consolidate descriptions pertaining to human cervix innervation and discuss possible mechanisms of dysfunction, as an unintended result of cervix removal. A detailed literature search of relevant articles describing human cervix innervation was conducted. 1597 articles were screened based on the keywords searched. Only 16 articles, containing information regarding specific evidence of the innervation of the human cervix, were included and categorized based on parameters of innervation (method, type, location). The published evidence demonstrates that the human cervix has sympathetic, parasympathetic, and sensory innervation, but does not characterize changes after surgical procedures. Despite the gaps in knowledge, it is relevant that associations linking clinical procedures, involving cervical removal and adverse sexual health outcomes, become an important focus for discussions between physicians and patients. Future work is needed to better detail the affected innervation as well as the neural pathway-specific relationship to symptoms of sexual dysfunction.

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Presence of sensory nerve corpuscles in the human corpus and cervix uteri during pregnancy and labor as revealed by immunohistochemistry

Cited by 14 publications

References 33 publications

Pregnancy‐induced analgesia: a combined psychophysical and neurophysiological study

Pregnancy‐induced analgesia: a combined psychophysical and neurophysiological study

Influence of pregnancy and labor on the occurrence of nerve fibers expressing the capsaicin receptor TRPV1 in human corpus and cervix uteri

The human cervix: Comprehensive review of innervation and clinical significance

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