Influence of pregnancy and labor on the occurrence of nerve fibers expressing the capsaicin receptor TRPV1 in human corpus and cervix uteri

Tingåker, Berith K; Ekman-Ordeberg, Gunvor; Facer, P.; Irestedt, L.; Anand, Praveen

doi:10.1186/1477-7827-6-8

Cited by 25 publications

(19 citation statements)

References 36 publications

(49 reference statements)

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“…Only few reports showed that PNI within the parametrial/pelvic tissue represents an adverse prognostic factor in primary or recurrent CX (Beitler et al 1997;Memarzadeh et al 2003). But, nerves occur not only in the parametrial/pelvic side wall tissue, but also in the cervical stroma (Bae et al 2001;Tingåker et al 2008) and are in that context involved in the contractility of the uterus and might also be a subject of invasion by carcinoma of the uterine cervix. The objective of this study was to estimate the frequency of PNI in squamous cell carcinoma of the cervix and the evaluation of its prognostic impact.…”

Section: Introductionmentioning

confidence: 97%

Perineural invasion in carcinoma of the cervix uteri—prognostic impact

Horn

Meinel

Fischer

et al. 2010

J Cancer Res Clin Oncol

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Section: Introductionmentioning

confidence: 97%

Perineural invasion in carcinoma of the cervix uteri—prognostic impact

Horn

Meinel

Fischer

et al. 2010

J Cancer Res Clin Oncol

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“…It is not known whether the Transient Receptor Potential (TRP) channel subtypes, TRPM8 and TRPA1, which have a role in cold sensation 24 are even expressed in the uterus or play a role in labor pain. However, TRPV1 receptors are upregulated in the human lower uterine segment and cervix at term 25and these receptors may form heterodimers with TRPA1 subunits in sensory neurons 26. Performing immunocytochemistry in order to detect these cold receptors in human pregnant uterus will be helpful to elucidate this issue.…”

Section: Discussionmentioning

confidence: 99%

β2-Adrenergic Receptor Genotype and Other Variables that Contribute to Labor Pain and Progress

Reitman¹,

Conell-Price²,

Evansmith

et al. 2011

Anesthesiology

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Background: ␤2-Adrenergic receptor (␤2AR) activity influences labor. Its genotype affects the incidence of preterm delivery. We determined the effect of ␤2AR genotype on term labor progress and maternal pain. Methods: We prospectively enrolled 150 nulliparous parturients in the third trimester and obtained sensory thresholds, demographic information, and DNA. Cervical dilation, pain scores, and labor management data were extracted with associated times. The association of genetic and demographic factors with labor was tested using mixed effects models.

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“…TRPV1 plays key regulatory role in thermal nociception [49] and is important in thermal hyperalgesia after inflammation or tissue injury [50]. TRPV1 channels are found on nociceptive axons in rat vagina [51] and human cervix [52]. In addition, estrogen enhances pain evoked by uterine distension via a TRPV1 receptor-dependent mechanism [53].…”

Section: Vasorelaxation Induced By Eugenol Involves Trpv1 Channel Actmentioning

confidence: 99%

Eugenol induces potent vasorelaxation in uterine arteries from pregnant goats – A promising natural therapeutic agent for hypertensive disorders of pregnancy

Parija

Jandhyam

Mohanty

et al. 2020

Preprint

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Please find attached our manuscript entitled “ Eugenol induces potent vasorelaxation in uterine arteries from pregnant goats – a promising natural therapeutic agent for hypertensive disorders of pregnancy ” Abstract Hypertensive disorders of pregnancy, including preeclampsia, affect about 8-13% of pregnancies and are the leading causes of pregnancy related maternal mortality worldwide. Poorly controlled high blood pressure during pregnancy increases the risk of pregnancy complications and development of future cardiovascular diseases. However, the choice for antihypertensive therapy during pregnancy has been limited due to side effects of many commonly used antihypertensive drugs and lack of other proven safe treatment options. Eugenol is a natural phenolic compound and the main component of clove oil. It is known for its antioxidant, anti-inflammatory and vasorelaxant actions. These beneficial effects of eugenol make it as an excellent therapeutic candidate for treatment of hypertensive disorders of pregnancy. Thus, as a first step, we compared the vasorelaxant effect of eugenol on the middle uterine arterial (MUA) rings from pregnant and nonpregnant goats. Additionally, we examined the potential involvement of the transient receptor potential channel 1 (TRPV1) in mediating the actions of eugenol and compared the effects with a known TRPV1 channel agonist, capsaicin. Isometric tension was measured in MUA rings from endometrial-myometrial junctions of pregnant and nonpregnant goats precontracted with phenylephrine, using a highly sensitive isometric force transducer and an automatic organ bath. The concentration-dependent contractile response curves of eugenol were compared to capsaicin, with and without pre-incubation of the MUA rings with a selective and non-selective TRPV1 antagonists, capsazepine (CAPZ) and Ruthenium Red (RR), respectively. Capsaicin induced concentration-dependent vasorelaxation in nonpregnant PE precontracted MUA rings and the concentration-response curve shifted to the right with significantly reduced pIC 50 and R max values in the presence of CAPZ and RR. The effects were similar in MUA rings from pregnant animals, except that there was a moderate increase in pIC 50 values in the presence of RR. Similarly, eugenol induced concentration-dependent vasorelaxation in both nonpregnant and pregnant PE precontracted MUA rings and the effects were markedly antagonized by CAPZ and RR. However, compared to capsaicin, the R max of eugenol was increased 31.25% in nonpregnant and 97.99% in pregnant MUA rings. These results suggest that eugenol has highly potent vasorelaxant effect in MUAs and its effect is partly mediated through activation of the TRPV1 channel. Most importantly, its vasorelaxant effect is about three-fold augmented in pregnancy, suggesting its potential value as a nutraceutical agent and therapeutic candidate for treatment of hypertensive disorders of pregnancy.

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Influence of pregnancy and labor on the occurrence of nerve fibers expressing the capsaicin receptor TRPV1 in human corpus and cervix uteri

Cited by 25 publications

References 36 publications

Perineural invasion in carcinoma of the cervix uteri—prognostic impact

Perineural invasion in carcinoma of the cervix uteri—prognostic impact

β2-Adrenergic Receptor Genotype and Other Variables that Contribute to Labor Pain and Progress

Eugenol induces potent vasorelaxation in uterine arteries from pregnant goats – A promising natural therapeutic agent for hypertensive disorders of pregnancy

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