Perineural invasion in carcinoma of the cervix uteri—prognostic impact

Horn, Lars‐Christian; Meinel, A.; Fischer, Uta; Bilek, K; Hentschel, Bettina

doi:10.1007/s00432-010-0813-z

Cited by 33 publications

(34 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…PNI and large tumor size were independent predictors of poor outcome in patients without LN invasion (Po0.05) (21). In another study on PNI in cervical cancer (IB1-IIB), 35.1% of patients (68 of 194 cases) had PNI (22). The presence of PNI was associated with stage, depth of invasion, and pelvic LN invasion (22).…”

Section: Perineural Invasion In Cervical Cancermentioning

confidence: 93%

“…In another study on PNI in cervical cancer (IB1-IIB), 35.1% of patients (68 of 194 cases) had PNI (22). The presence of PNI was associated with stage, depth of invasion, and pelvic LN invasion (22). However, PNI reduced 5-yr OS, but 5-yr DFS was not different (22).…”

Section: Perineural Invasion In Cervical Cancermentioning

confidence: 94%

“…The presence of PNI was associated with stage, depth of invasion, and pelvic LN invasion (22). However, PNI reduced 5-yr OS, but 5-yr DFS was not different (22). In multivariate analysis, PNI and LN metastasis were independent prognostic factors for OS (22).…”

Section: Perineural Invasion In Cervical Cancermentioning

confidence: 95%

“…However, PNI reduced 5-yr OS, but 5-yr DFS was not different (22). In multivariate analysis, PNI and LN metastasis were independent prognostic factors for OS (22). One other study reported the incidence of PNI in earlystage (IA-IIA) cervical cancer (23).…”

Section: Perineural Invasion In Cervical Cancermentioning

confidence: 97%

See 3 more Smart Citations

Prognostic Significance of Perineural Invasion in Cervical Cancer

Cho

Kim

Cho

et al. 2013

International Journal of Gynecological Pathology

View full text Add to dashboard Cite

Perineural invasion (PNI) has attracted attention as a new prognostic factor for cancer. We aimed to investigate the prognostic value of PNI in patients with cervical cancer. Clinical data of 185 patients with early-stage cervical cancer (stages IA2-IIA2) who underwent radical hysterectomy and pelvic lymphadenectomy between 2003 and 2011 were investigated. PNI was detected in 7% (13 of 18 cases) of patients. Moreover, 92% (12 of 13 cases) of patients with PNI received radiation therapy or concurrent chemoradiation therapy after surgery. We investigated whether PNI can be a new indication for adjuvant therapy for cervical cancer. In our study, PNI had a significant association with well-known indications for adjuvant therapy (92.3% sensitivity, 50% specificity, odds ratio 12.0, P = 0.003). Multivariate analysis showed that parametrial invasion and lymphovascular invasion were independently associated with PNI (P < 0.05). However, statistical analysis did not show differences in disease-free survival (P = 0.292) or overall survival (P = 0.346) according to the presence of PNI. In conclusion, PNI as an independent predictor for prognosis was limited, but PNI had a significant association with prognostic factors. PNI may be a new risk factor candidate for cervical cancer. PNI is expected to help in decision making for the need for adjuvant therapy.

show abstract

Section: Perineural Invasion In Cervical Cancermentioning

confidence: 93%

Section: Perineural Invasion In Cervical Cancermentioning

confidence: 94%

Section: Perineural Invasion In Cervical Cancermentioning

confidence: 95%

Section: Perineural Invasion In Cervical Cancermentioning

confidence: 97%

See 2 more Smart Citations

Prognostic Significance of Perineural Invasion in Cervical Cancer

Cho

Kim

Cho

et al. 2013

International Journal of Gynecological Pathology

View full text Add to dashboard Cite

show abstract

“…However, most studies agree that PNI of cervical cancer is strongly associated with a number of risk factors and associated with poor prognosis of cervical cancer (26). Horn et al (27) reported that PNI was associated with post-operative tumor stage, cervical stromal invasion, and pelvic lymph node metastasis in early cervical cancer patients. The authors also identified that the 5-year survival rate of cervical cancer patients with PNI was significantly lower than that of patients with negative PNI.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the association between perineural invasion and clinical and histopathological features of cervical cancer

Wei

Yao

Liu

2016

Molecular and Clinical Oncology

View full text Add to dashboard Cite

Abstract. Perineural invasion (PNI) has been investigated as a new prognostic factor in a number of carcinomas. However, studies on PNI in cervical cancer are limited, and inconsistent conclusions have been reported by different groups. The aim of the present study was to analyze the relationship between perineural invasion (PNI) and clinical and histopathological features of cervical cancer, and to evaluate the clinical significance of PNI of cervical cancer. Retrospective review identified 206 patients with cervical cancer who underwent radical hysterectomy plus pelvic lymphadenectomy between December 2012 and August 2014. The association between PNI and clinical and histopathological features of cervical cancer and post-operative radiotherapy was evaluated based on univariate and multivariate analyses. PNI of cervical cancer was identified in 33 of 206 (16%) cervical cancer patients. Univariate analysis demonstrated that PNI was associated with clinical stage, tumor grade, tumor size, depth of invasion, lymphovascular space invasion (LVSI), and lymph node metastasis (P<0.05), but not associated with age and histopathological types (P>0.05). Multivariate analysis suggests that LVSI and lymph node metastasis were associated with PNI of cervical cancer (P<0.05). In addition, post-operative radiotherapy was significantly more recommended for patients with PNI than those without PNI (P<0.001). In conclusion, PNI of cervical cancer is associated with LVSI and lymph node metastasis and can be used as an index for the determination of post-operative radiotherapy for cervical cancer patients.

show abstract