Presence of Neutralizing Antibody against the 229E Strain of Coronavirus in the Sera of Residents of Sendai

Miyazaki, Keizo; Tsunoda, Akira; Kumasaka, Mayuko Y.; Ishida, Nakao

doi:10.1111/j.1348-0421.1971.tb00580.x

Cited by 6 publications

(6 citation statements)

References 10 publications

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“…To assess the capability of human antibodies to neutralize the HCoV-229E-related dromedary viruses, a microneutralization assay was established. Human neutralizing antibody titers against HCoV-229E are known to be very low in general (29). We screened our serum archive for human sera that had measurable neutralization titers against HCoV-229E.…”

Section: Dromedary-derived Viruses Are Neutralized In Vitro By Human mentioning

confidence: 99%

Link of a ubiquitous human coronavirus to dromedary camels

Corman

Eckerle

Memish

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

133

140

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The four human coronaviruses (HCoVs) are globally endemic respiratory pathogens. The Middle East respiratory syndrome (MERS) coronavirus (CoV) is an emerging CoV with a known zoonotic source in dromedary camels. Little is known about the origins of endemic HCoVs. Studying these viruses’ evolutionary history could provide important insight into CoV emergence. In tests of MERS-CoV–infected dromedaries, we found viruses related to an HCoV, known as HCoV-229E, in 5.6% of 1,033 animals. Human- and dromedary-derived viruses are each monophyletic, suggesting ecological isolation. One gene of dromedary viruses exists in two versions in camels, full length and deleted, whereas only the deleted version exists in humans. The deletion increased in size over a succession starting from camelid viruses via old human viruses to contemporary human viruses. Live isolates of dromedary 229E viruses were obtained and studied to assess human infection risks. The viruses used the human entry receptor aminopeptidase N and replicated in human hepatoma cells, suggesting a principal ability to cause human infections. However, inefficient replication in several mucosa-derived cell lines and airway epithelial cultures suggested lack of adaptation to the human host. Dromedary viruses were as sensitive to the human type I interferon response as HCoV-229E. Antibodies in human sera neutralized dromedary-derived viruses, suggesting population immunity against dromedary viruses. Although no current epidemic risk seems to emanate from these viruses, evolutionary inference suggests that the endemic human virus HCoV-229E may constitute a descendant of camelid-associated viruses. HCoV-229E evolution provides a scenario for MERS-CoV emergence.

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Section: Dromedary-derived Viruses Are Neutralized In Vitro By Human mentioning

confidence: 99%

Link of a ubiquitous human coronavirus to dromedary camels

Corman

Eckerle

Memish

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

133

140

View full text Add to dashboard Cite

show abstract

“…After the identification in the 1960s of the first CoVs known to cause human disease, HCoV-229E and HCoV-OC43, and their association with mild respiratory disease [30,34,67,84,137,142], little new information emerged in this field until the beginning of the twenty-first century. In 2002/2003, a CoV appeared in the Guangdong province of China, causing severe acute respiratory syndrome (SARS) [56,108,156].…”

Section: Human Coronavirusesmentioning

confidence: 99%

Emerging Viral Infections

Schildgen

2010

Pulmonary Involvement in Patients With Hematological Malignancies

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“…In the USA and England, 229E and OC43 viruses are responsible for 1-30% of all clinical cases [75,84,104,131,180], with approximately an equal number of subclinical infections. Studies from around the world -Italy [30,48], Finland [143], India [118], Germany [60,148], Czech Republic [72], Japan [119,121], Romania [150] -show that coronavirus infections are just as common.…”

Section: Epidemiology 149mentioning

confidence: 99%