Presence of Interleukin 10 in the Serum and Blister Fluid of Patients With Pemphigus Vulgaris and Pemphigoid

Bhol, Kailash; Rojas, Adriana I.; Khan, Inayat; Ahmed, A. Razzaque

doi:10.1006/cyto.1999.0642

Cited by 55 publications

(36 citation statements)

References 39 publications

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“…Among its other biological activities, IL-10 induces B lymphocytes to proliferate and differentiate to produce antibodies and therefore may also play a role in the production of auto-antibodies specific for pemphigus. Recently Bhol et al [13]have detected that the levels of IL-10 were approximately 4 times higher in the blister fluid than the levels in the serum of the same PV patients. High levels of IFN-γ in pemphigus blister fluid and in serum samples suggested a role of activated T cells in pemphigus.…”

Section: Discussionmentioning

confidence: 99%

Cytokine Pattern in Blister Fluid and Sera of Patients with Pemphigus

Baroni¹,

Perfetto

Ruocco³

et al. 2002

Dermatology

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Background: Pemphigus is a chronic auto-immune blistering disease with four main variants, i.e. pemphigus vulgaris (PV), foliaceus (PF), erythematosus (PE) and vegetans. The common histological feature of this disease is acantholysis. Objective: The aim of this study was to compare levels of some cytokines in blister fluid and sera of patients with pemphigus, using as control blister fluid of patients with bullous pemphigoid (BP) and bullous contact dermatitis (BCD). Methods: Using an immuno-enzymatic assay (ELISA), we tested 16 sera and 6 blister fluids of patients with various forms of pemphigus (13 with PV, 1 with PF, 2 with PE), the sera of 16 healthy control subjects, 5 blister fluids of patients with BP and 5 blister fluids of patients with BCD, for the presence of some cytokines (IL-10, IL-8 and IFN-γ). Intercellular antibodies were searched for and titred; desmoglein 1 and 3 antibody levels were independently evaluated to compare them with the severity of both cutaneous and oral involvement. Results: The levels of IL-10 in the sera of patients with pemphigus were below the detection limits. IL-8 was significantly increased only in 4 samples of sera from pemphigus patients compared with controls, while IFN-γ was detected at low levels in almost all patients compared with sera of controls. The cytokine levels in blister fluid of patients with pemphigus were significantly higher than in the sera. There was a difference between the expression of cytokines in blister fluid of control patients with BP and BCD compared with those of pemphigus patients. Conclusion: This report discusses the anti-inflammatory role played by IL-10 in the chronic form of pemphigus and the hypothesis of a possible role of IL-8 in neutrophil and lymphocyte-monocyte recruitment.

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Section: Discussionmentioning

confidence: 99%

Cytokine Pattern in Blister Fluid and Sera of Patients with Pemphigus

Baroni¹,

Perfetto

Ruocco³

et al. 2002

Dermatology

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“…Increased levels of IL-10 in sera and blister fluid have been described for PV, and in one study, IL-10 levels were also correlated to titers of pemphigus autoantibodies and disease severity. 120 One group identified autoreactive desmoglein-3 specific CD4ϩ T cells in PV patients and noted their propensity to produce IL-4 and IL-10. Also, Th2-dependent IgG4 autoantibodies were preferentially seen in active stages of PV, while Th1-dependent IgG1 autoantibodies were seen upon remission.…”

Section: Autoimmune Bullous Diseases: Pemphigus Vulgarismentioning

confidence: 99%

The role of interleukin 10 in the pathogenesis and potential treatment of skin diseases

Weiss

Mamelak

Morgia

et al. 2004

Journal of the American Academy of Dermatology

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“…Barioni et al 18 reported that the IL-10 levels in the serum of PV patients are below the detection limits when compared to other skin diseases. On the contrary, Bhol et al 19 and D'Auria et al, 20 reported that increased levels of IL-10 have been detected in PV patients' serum compared to normal individuals and these cytokine levels correlate with severity of disease. IL-10 is an immune regulatory lymphokine, produced by T-cells, B-cells, macrophages, mast cells, eosinophils, keratinocytes and some tumor cells.…”

Section: Discussionmentioning

confidence: 94%

“…In this manner, it may limit the damage and prevent more extension of lesions in the skin and mucous membranes. 18,19 However, the increased levels of these cytokines in serum of PV patients compared to normal subjects might be according to the proinflammatory or immunoregulatory action of these molecules in this autoimmune and inflammatory disease. In addition, the results of this study may have significant utility in the evaluation of chemointerventional therapy.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Interleukin-1α, Interleukin-10, Tumor Necrosis Factor-α and transforming Growth Factor-β in the Serum of Patients with Pemphigus Vulgaris

Khozeimeh¹,

Savabi²,

Esnaashari³

2014

The Journal of Contemporary Dental Practice

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Pemphigus is an autoimmune blistering disease characterized by a loss of cell adhesion result in acantholysis. Genetic factors and immunologic factors such as cytokines particularly IL-1α, IL-10, TNF-α, and TGF-β may counterpart to developing of Pemphigus. The aim of this study was to evaluate. The concentration of IL-1α, IL-10, TNF-α, TGF-β in serum of pemphigus vulgaris (PV) patients and normal individuals. Material and methods:In this analytic and descriptive study 25 patients with pemphigus vulgaris (in active phase) and 25 healthy persons were examined. Serum samples of two groups were obtained and the level of IL-1α, IL-10, TNF-α and TGF-β were measured by ELISA technique. The data were analyzed statistically by independent T test (α = 0/05).

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Presence of Interleukin 10 in the Serum and Blister Fluid of Patients With Pemphigus Vulgaris and Pemphigoid

Cited by 55 publications

References 39 publications

Cytokine Pattern in Blister Fluid and Sera of Patients with Pemphigus

Cytokine Pattern in Blister Fluid and Sera of Patients with Pemphigus

The role of interleukin 10 in the pathogenesis and potential treatment of skin diseases

Evaluation of Interleukin-1α, Interleukin-10, Tumor Necrosis Factor-α and transforming Growth Factor-β in the Serum of Patients with Pemphigus Vulgaris

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