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Cited by 76 publications
(58 citation statements)
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References 172 publications
(123 reference statements)
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“…However, recent studies suggested the primary T-cell source for IL-10 is Th3 (also referred to as Tr1), and IL-10 suppress Th1 as well as Th2 immune responses. 20) Especially, IL-10 is reported to inhibit eosinophil survival and IL-4-induced IgE synthesis. 21) In addition to above immunesuppressive role, IL-10 is well-known to typical anti-inflammatory cytokine.…”
Section: Effects On Clinical Skin Severitymentioning
confidence: 99%
“…However, recent studies suggested the primary T-cell source for IL-10 is Th3 (also referred to as Tr1), and IL-10 suppress Th1 as well as Th2 immune responses. 20) Especially, IL-10 is reported to inhibit eosinophil survival and IL-4-induced IgE synthesis. 21) In addition to above immunesuppressive role, IL-10 is well-known to typical anti-inflammatory cytokine.…”
Section: Effects On Clinical Skin Severitymentioning
confidence: 99%
“…The SI values obtained by protein (DEAE) fractions were 50-70% lower than the values induced by intact living leishmania parasites and 90% lower than the total stimulation obtained by the T cell mitogen ConA. This suggests their stimulation potential in vitro appears to be selectively focus toward a particular subset of lymphocytes which may be regulatory CD8+ T cells as published (O'Daly et al 2009a;O'Daly et al, 2009b;O'Daly et al, 2010a;O'Daly et al, 2011) 7.5 The role of IL-10 in parasitic defense and autoimmune disease IL-10 plays an important role in many skin autoimmune diseases, and in certain parasitic infections, in humans as well as in experimental animals (Weiss et al, 2004). IL-10 stimulates NK cells cytotoxicity and IL-2 inducing IFNγ and TNF production.…”
Section: No Prior Sensitization Required To Recognize Amastigote Antimentioning
confidence: 99%
“…This cytokine is known to suppress the production of Th1 proinflammatory cytokines such as tumor necrosis factor-a (TNF-a), interferon-g (IFN-g), and IL-12, which are correlated with overt liver disease, including fibrosis and portal inflammation, and is able to enhance B-cell survival, and proliferation, and to stimulate the production of antibodies (10)(11)(12)(13). Our group previously observed that patients with chronic HCV, who had not responded to previous IFN-based therapy, had decreased disease activity after long-term IL-10 therapy (14).…”
Section: Introductionmentioning
confidence: 99%