Presence of Granulomas in Mesenteric Lymph Nodes Is Associated with Postoperative Recurrence in Crohnʼs Disease

Li, Yang; Stocchi, Luca; Liu, Xiuli; Rui, Yuanyi; Liu, Ganglei; Remzi, Feza H.; Shen, Bo

doi:10.1097/mib.0000000000000541

Cited by 72 publications

(38 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This was not studied in this observational multicentric cohort but in future prospective studies it could be included in the protocols. One study suggested that granulomas in the mesenteric lymph nodes may also play a role in increasing recurrence rates after ileocaecal resection . This is an interesting finding, as CD inflammation is usually triggered in the mesenteric fat.…”

Section: Discussionmentioning

confidence: 97%

Factors affecting the incidence of early endoscopic recurrence after ileocolonic resection for Crohn's disease: a multicentre observational study

et al. 2017

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 97%

Factors affecting the incidence of early endoscopic recurrence after ileocolonic resection for Crohn's disease: a multicentre observational study

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Our recent data showed that the presence of non-caseating granulomas in mesenteric lymph nodes, but not in the intestine per se, was associated with an increased risk for postoperative recurrence in CD. 164 In patients with CD, the mechanism for the formation of granulomas in mesenteric lymph nodes remains speculative. Granulomata in lymph nodes may be caused by defective lymphatic drainage and subsequently lymph static accumulation of antigens and histiocytemediated inflamamtion.…”

Section: Lymphatics In the Pathogenesis Of CDmentioning

confidence: 99%

The Role of the Mesentery in Crohnʼs Disease

Zhu

Zuo

et al. 2016

Inflammatory Bowel Diseases

Self Cite

View full text Add to dashboard Cite

Crohn's disease (CD) is a complex gastrointestinal disorder involving multiple levels of cross talk between the immunological, neural, vascular, and endocrine systems. The current dominant theory in CD is based on the unidirectional axis of dysbiosis-innate immunity-adaptive immunity-mesentery-body system. Emerging clinical evidence strongly suggests that the axis be bidirectional. The morphologic and/or functional abnormalities in the mesenteric structures likely contribute to the disease progression of CD, to a less extent the disease initiation. In addition to adipocytes, mesentery contains nerves, blood vessels, lymphatics, stromal cells, and fibroblasts. By the secretion of adipokines that have endocrine functions, the mesenteric fat tissue exerts its activity in immunomodulation mainly through response to afferent signals, neuropeptides, and functional cytokines. Mesenteric nerves are involved in the pathogenesis and prognosis of CD mainly through neuropeptides. In addition to angiogenesis observed in CD, lymphatic obstruction, remodeling, and impaired contraction maybe a cause and consequence of CD. Lymphangiogenesis and angiogenesis play a concomitant role in the progress of chronic intestinal inflammation. Finally, the interaction between neuropeptides, adipokines, and vascular and lymphatic endothelia leads to adipose tissue remodeling, which makes the mesentery an active participator, not a bystander, in the disease initiation and precipitation CD. The identification of the role of mesentery, including the structure and function of mesenteric nerves, vessels, lymphatics, and fat, in the intestinal inflammation in CD has important implications in understanding its pathogenesis and clinical management.

show abstract

“…In a recent report, the presence of granulomas in the mesenteric lymph nodes was found to be an independent risk factor for ER (27).…”

Section: Discussionmentioning

confidence: 99%

Updating predictors of endoscopic recurrence after ileocolic resection for Crohn disease

Monteiro¹,

Gonçalves²,

Carvalho³

et al. 2017

Turk J Gastroenterol

View full text Add to dashboard Cite

Presence of Granulomas in Mesenteric Lymph Nodes Is Associated with Postoperative Recurrence in Crohnʼs Disease

Abstract: The presence of granulomas in MLN but not in intestine per se was found to be an independent risk factor for recurrence in CD patients undergoing ileocolonic resection.

Cited by 72 publications

References 60 publications

Factors affecting the incidence of early endoscopic recurrence after ileocolonic resection for Crohn's disease: a multicentre observational study

Factors affecting the incidence of early endoscopic recurrence after ileocolonic resection for Crohn's disease: a multicentre observational study

The Role of the Mesentery in Crohnʼs Disease

Updating predictors of endoscopic recurrence after ileocolic resection for Crohn disease

Contact Info

Product

Resources

About