Presence of cholinergic and calcium channel blocking activities explains the traditional use of Hibiscus rosasinensis in constipation and diarrhoea

Gilani, Anwarul Hassan; Bashir, Samra; Janbaz, Khalid Hussain; Shah, Abdul Jabbar

doi:10.1016/j.jep.2005.07.023

Cited by 78 publications

(66 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although preliminary studies are under way in different laboratories to use the antispasmodic, antiinflammatory, antihypertensive and diuretic activities of M. oleifera seed, these studies (Gilani et al, 2000;2005a;Bashir et al, 2006) might be of some guidance in designing experiments in which the presence of antispasmodic constituents at higher doses are explained as a possible mode to offset the side-effects usually associated with high dose of laxative therapy. Similarly, the known species differences in the pharmacological actions of medicinal plants (Ghayur et al, 2005; may also be taken into account when planning studies involving contradictory results.…”

Section: Future Prospectsmentioning

confidence: 99%

Moringa oleifera: a food plant with multiple medicinal uses

Anwar

Latif

Ashraf

et al. 2006

Phytotherapy Research

1,397

1,009

View full text Add to dashboard Cite

show abstract

Section: Future Prospectsmentioning

confidence: 99%

Moringa oleifera: a food plant with multiple medicinal uses

Anwar

Latif

Ashraf

et al. 2006

Phytotherapy Research

1,397

1,009

View full text Add to dashboard Cite

show abstract

“…While action potential for maximal depolariza -tion is produced through a rapid influx of Ca 2+ via the VDLCs (voltage-dependent L type channels) or released from sarcoplasmic reticulum calcium stores (Brading and Sneddon, 1980;Karaki et al, 1997;Bashir et al, 2011). The decrease in the spontaneous movements of jejunum by crude extract is assumed to be mediated through Ca 2+ channels blockade (Janbaz et al, 2012), as it was earlier observed that the antispasmodic constituents found in various medicinal plants inhibited the Ca 2+ movement to produce their effect (Gilani et al, 2005a(Gilani et al, , 2005b. The antispasmodic activity of the crude extract was further concluded by administrating on K + (80 mM)-induced contractions in isolated rabbit jejunum tissues.…”

Section: Discussionmentioning

confidence: 98%

Ethnopharmacological evaluation of Cenchrus ciliaris for multiple gastrointestinal disorders

Aleem

Janbaz

2017

Bangladesh J Pharmacol

View full text Add to dashboard Cite

This study was conducted to rationalize the traditional uses of Cenchrus ciliaris in gastrointestinal disorders using in vivo and ex vivo assays. The antidiarrheal effect was evaluated in rats by the castor oil-induced diarrheal model. C. ciliaris (100, 300 and 500 mg/kg) reduced the castor oil-induced diarrhea significantly. Another study carried out in mice to determine the intestinal transit rate showed that C. ciliaris (100 and 200 mg/kg) inhibited the transit rate significantly. Ex vivo assay demonstrated that C. ciliaris (0.01–1 mg/mL) relaxed the spontaneous and K+ (80 mM)-induced contractions, like verapamil. The crude extract (75, 100 and 150 mg/kg) also exhibited significant anti-emetic activity in chicks. These results indicate the presence of antispasmodic, antidiarrheal and antiemetic activities in C. ciliaris, thus providing the scientific basis for its traditional uses.Video Clip of Methodology: 56 sec <a href="https://www.youtube.com/v/FwQ01gHJaGk">Full Screen</a> <a href="https://www.youtube.com/watch?v=FwQ01gHJaGk">If Failed</a>

show abstract

“…Phenols have also been termed as antinutritional because of their tendency to bind positively charged proteins and minerals in foods and reduce their digestibility (Gilani et al 2005). However, these antinutritional traits have been trounced by their ability to act as reducing agents, hydrogen donors and chelators of metal ions (Decker 1995) as well as their ability to act as inhibitors of low density lipoproteins, cholesterol oxidation and DNA breakage (Shahidi 2004).…”

Section: Discussionmentioning

confidence: 99%

Appraisal of maize germplasm for identification of nutritionally rich nutraceutical genotypes

Kaur

2016

Cereal Research Communications

View full text Add to dashboard Cite

Thirty maize genotypes were characterized for their nutritional, antinutritional and nutraceutical traits for identification of elite germplasm rich in beneficial characteristics. Starch, proteins, lipids, tryptophan, lysine, β-carotene, condensed tannins, protease inhibitor, phytic acid, total phenols, flavonols, o-dihydroxy phenols and DPPH radical scavenging activity were determined in grains of all the genotypes. Correlation coefficient among the various parameters showed that lysine, total phenols, flavonols and o-dihydroxy phenols were negatively correlated with phytic acid content of the genotypes. This showed that the nutritional and the nutraceutical potency of genotypes, rich in lysine and phenolic compounds, is further propounded by a reduction of phytic acid content in them. On the basis of various constituents, the genotypes were divided into three groups. Group-A genotypes had high to moderate levels of both nutritional and nutraceutical traits. Group-B included those genotypes that exhibited high to moderate levels of either nutritional or nutraceutical traits. Group-C was constituted of genotypes that had lower levels of both nutritional and nutraceutical traits. Agglomerative hierarchical clustering showed that the D subcluster of MC-2 was chiefly comprised of genotypes that had high to moderate levels of both nutritional and nutraceutical traits. It may be concluded that CML134, CML266, TOO14601, LM11, CML264, CML321, SE563, LM10, LM18, LM14 and CML32 were nutritionally rich nutraceutical genotypes having low antinutrient potency.

show abstract

Presence of cholinergic and calcium channel blocking activities explains the traditional use of Hibiscus rosasinensis in constipation and diarrhoea

Cited by 78 publications

References 15 publications

Moringa oleifera: a food plant with multiple medicinal uses

Moringa oleifera: a food plant with multiple medicinal uses

Ethnopharmacological evaluation of Cenchrus ciliaris for multiple gastrointestinal disorders

Appraisal of maize germplasm for identification of nutritionally rich nutraceutical genotypes

Contact Info

Product

Resources

About