Presence of bovine hepacivirus in Turkish cattle

Yeşilbağ, Kadir; Baechlein, Christine; Kadiroğlu, Berfin; Toker, Eda Baldan; Alpay, Gizem; Becher, Paul

doi:10.1016/j.vetmic.2018.09.001

Cited by 11 publications

(17 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…BovHepV is the newest member of hepaciviruses and apparently only infects cattle (da Silva et al., 2018). Since its first report in Germany in 2015 (Baechlein et al., 2015), bovine hepacivirus has been detected in several countries, showing a global distribution of the virus with different prevalence values, ranging from 1.6% in Germany to 3,82% in China, to 8.5% in Ghana and to 12.5% in Turkey (Baechlein et al., 2015; Corman et al., 2015; Deng et al., 2018; Yesilbag et al., 2018). In order to assess the circulation of BovHepV in Italy, a total of 24,820 bovine serum samples from different areas of Italy were screened molecularly.…”

Section: Discussionmentioning

confidence: 99%

“…BovHepV was first detected in serum samples from domestic cattle in Germany and Ghana (Baechlein et al., 2015; Corman et al., 2015), in two independent studies. Since then, BovHepV has been described in archived serum samples from Brazil (Canal et al., 2017), in calf serum from the United States and China (Lu, Ou, Zhao, & Li, 2019; Sadeghi et al., 2017), and in cattle from China (Deng, Guan, Wang, Hao, & Rasmussen, 2018; Lu et al., 2018) and Turkey (Yesilbag et al., 2018), thus suggesting a worldwide distribution.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Genetic heterogeneity of bovine hepacivirus in Italy

Elia

Caringella

Lanave

et al. 2020

Transbound. Emerg. Dis.

View full text Add to dashboard Cite

Viruses similar to human hepatitis C virus (HCV) in the Hepacivirus genus have been identified in several animal hosts, including cattle. Since its first discovery in Germany, bovine hepacivirus (BovHepV) has been described in several countries globally. However, limited data are available on BovHepV epidemiology and genetic variability. The aim of this study was to investigate the prevalence and genetic diversity of BovHepV in Italy. Viral RNA was identified in 37 (0.15%) of 24,820 bovine sera, with titres ranging from 1.09 × 10 3 to 8.27 × 10 6 RNA copies/ml. Upon sequencing and phylogenetic analysis of the 5′UTR and NS3 genomic portions, the Italian BovHepV strains segregated into at least four distinct subtypes (A, B, C and F) that are also co-circulating globally.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Genetic heterogeneity of bovine hepacivirus in Italy

Elia

Caringella

Lanave

et al. 2020

Transbound. Emerg. Dis.

View full text Add to dashboard Cite

show abstract

“…BovHepV is hepatotropic, and causes acute or persistent infections in cattle [10,23]. Since its first discovery in cattle from Germany [10] and Ghana [11] in 2015, it has been detected in Brazil [24,25], Turkey [26], USA [27], China [28][29][30][31], and Italy [32], suggesting a worldwide distribution of BovHepV. As per the demarcation criteria for HCV genotyping and subtyping, BovHepV strains have been classified into two genotypes, and genotype 1 could be further divided into seven subtypes (A to G) [28,31].…”

Section: Introductionmentioning

confidence: 99%

A Novel Subtype of Bovine Hepacivirus Identified in Ticks Reveals the Genetic Diversity and Evolution of Bovine Hepacivirus

Shao

Guo

et al. 2021

Viruses

View full text Add to dashboard Cite

Hepaciviruses represent a group of viruses that pose a significant threat to the health of humans and animals. New members of the genus Hepacivirus in the family Flaviviridae have recently been identified in a wide variety of host species worldwide. Similar to the Hepatitis C virus (HCV), bovine hepacivirus (BovHepV) is hepatotropic and causes acute or persistent infections in cattle. BovHepVs are distributed worldwide and classified into two genotypes with seven subtypes in genotype 1. In this study, three BovHepV strains were identified in the samples of ticks sucking blood on cattle in the Guangdong province of China, through unbiased high-throughput sequencing. Genetic analysis revealed the polyprotein-coding gene of these viral sequences herein shared 67.7–84.8% nt identity and 76.1–95.6% aa identity with other BovHepVs identified worldwide. As per the demarcation criteria adopted for the genotyping and subtyping of HCV, these three BovHepV strains belonged to a novel subtype within the genotype 1. Additionally, purifying selection was the dominant evolutionary pressure acting on the genomes of BovHepV, and genetic recombination was not common among BovHepVs. These results expand the knowledge about the genetic diversity and evolution of BovHepV distributed globally, and also indicate genetically divergent BovHepV strains were co-circulating in cattle populations in China.

show abstract

“…This virus was identified for the first time in Ghana and Germany by two independent research groups in 2015 [6,7]. Several studies have indicated that BovHepV has a wide geographical distribution worldwide, including in Brazil [13,14], China [15,16], the USA [17], and Turkey [18]. Viral RNA screening has demonstrated that the prevalence of BovHepV in different countries ranges from 0.6% to 14.8%.…”

Section: Introductionmentioning

confidence: 99%

“…According to a study by da Silva et al in 2018, BovHepV is classified into one genotype (genotype 1) and four subtypes (subtypes A–D) based on the classification principle for HCV [14]. After this report, several investigations on the BovHepV genome in China, Turkey and Germany have been published, indicating that BovHepV is more genetically divergent than previously described [15,16,18,21].…”

Section: Introductionmentioning

confidence: 99%

Presence of a Novel Subtype of Bovine Hepacivirus in China and Expanded Classification of Bovine Hepacivirus Strains Worldwide into 7 Subtypes

2019

Viruses

View full text Add to dashboard Cite

The newest member of the Hepacivirus genus, bovine hepacivirus (BovHepV), was first identified in cattle in 2015 and is a novel hepacivirus C virus (HCV)-like virus. This virus has been detected in five countries so far and is classified into four subtypes. Bovine serum is commonly used for cell cultures and is considered the major source of viral contamination of pharmaceutical products. In this study, bovine serum samples were collected from seven countries located in Asia, America, Oceania, and Europe and were tested for BovHepV RNA using nested PCR, in order to: (i) obtain more knowledge on the geographical distribution and subtypes of BovHepV; and (ii) detect the potential contamination of BovHepV in commercial bovine serum samples used for cell culture propagation. The results demonstrated that bovine serum samples from individual donor cattle in China contained BovHepV RNA. After PCR, sequencing, and assembly, the genomes of the Chinese BovHepV strains were obtained. Genetic analysis of the polyprotein gene revealed a protein identity of <77% and a nucleotide identity of <85% between the Chinese BovHepV strains and all other previously reported BovHepV strains. Using cut-off values for determination of HCV genotypes and subtypes, BovHepV strains worldwide were classified into one unique genotype and seven subtypes. The BovHepV strains identified in the present study were classified into a novel subtype, which was provisionally designated subtype G. The genetic relationships among the different BovHepV subtypes were further confirmed through phylogenetic analysis. The present study provides critical insights into BovHepV’s geographical distribution and genetic variability.

show abstract

Presence of bovine hepacivirus in Turkish cattle

Cited by 11 publications

References 18 publications

Genetic heterogeneity of bovine hepacivirus in Italy

Genetic heterogeneity of bovine hepacivirus in Italy

A Novel Subtype of Bovine Hepacivirus Identified in Ticks Reveals the Genetic Diversity and Evolution of Bovine Hepacivirus

Presence of a Novel Subtype of Bovine Hepacivirus in China and Expanded Classification of Bovine Hepacivirus Strains Worldwide into 7 Subtypes

Contact Info

Product

Resources

About