Presence of autoantibodies in women with unexplained infertility

Taylor, Pamela V.; Campbell, James M.; Scott, James S.

doi:10.1016/0002-9378(89)90524-3

Cited by 81 publications

(28 citation statements)

References 14 publications

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“…A role for aPL as a possible cause of failure to achieve pregnancy after in vitro fertilization (IVF), however, is controversial. An association between the hypercoagulable state because of the presence of aPL and unsuccessful embryo implantation has been observed in some [3], but not in other studies [4][5][6]. Pregnancy complications constitute one of the two major clinical criteria of the antiphospholipid syndrome (APS) [7] and adverse pregnancy outcomes may result from poor placental perfusion because of localized thrombosis.…”

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confidence: 99%

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Antiphospholipid antibodies and antibodies to tissue factor pathway inhibitor in women with implantation failures or early and late pregnancy losses

Martinuzzo

Varela

Adamczuk

et al. 2005

Journal of Thrombosis and Haemostasis

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To cite this article: Martinuzzo M, Iglesias Varela ML, Adamczuk Y, Broze GJ, Forastiero R. Antiphospholipid antibodies and antibodies to tissue factor pathway inhibitor in women with implantation failures or early and late pregnancy losses. J Thromb Haemost 2005; 3: 2587-9.The association of antiphospholipid antibodies (aPL) with early recurrent spontaneous abortions and fetal deaths is well established [1,2]. A role for aPL as a possible cause of failure to achieve pregnancy after in vitro fertilization (IVF), however, is controversial. An association between the hypercoagulable state because of the presence of aPL and unsuccessful embryo implantation has been observed in some [3], but not in other studies [4][5][6]. Pregnancy complications constitute one of the two major clinical criteria of the antiphospholipid syndrome (APS) [7] and adverse pregnancy outcomes may result from poor placental perfusion because of localized thrombosis. Recently, we found that high titers of antibodies to tissue factor pathway inhibitor (TFPI) (anti-TFPI) in women with autoimmune aPL seem to increase the risk of aPL-related reproductive failures [8]. TFPI is a Kunitz-type protease inhibitor that tightly regulates tissue factor-mediated coagulation. During normal pregnancy, some of the hemostatic changes occurring in the placenta are characterized by increased tissue factor expression and low expression of TFPI. Both tissue factor and TFPI seem to be essential for the maintenance of hemostasis in the placenta [9]. The objective of the present study was to evaluate the presence of aPL [lupus anticoagulant (LA) and moderate or high titers of anticardiolipin antibodies (aCL)] and anti-TFPI in women with a history of pregnancy loss, as well as in women with recurrent IVF failures.The study included patients referred to our institution in Argentina for evaluation of aPL because of a history of two or more consecutive spontaneous abortions (early pregnancy loss before 10 weeks of gestation), at least one fetal death (late pregnancy loss at or beyond 10 weeks of gestation) or recurrent (two or more) IVF failures despite good visual quality embryos. Patients were referred after excluding other common etiologies of pregnancy failures (infections and hormonal, metabolic, uterine anatomic or genetic abnormalities). There were 243 women (median age 32 years old, range 21-37) with early and/ or late pregnancy losses (98 with early, 116 with late, and 29 with both), and 48 (median age 33 years old, range 23-39) with IVF failures. The median number of pregnancy losses was three (range 2-7) in the early group and two (range 1-5) in the late group, and the median number of IVF procedures was three (range 2-6) in the IVF failure group. A group of 80 normal control women (median age 35 years old, range 25-42) was also evaluated. They had had only successful pregnancies. None of the patients or control women had a history of thrombosis or systemic lupus erythematosus. In all cases, blood collection took place at least 3 months after pregnancy compli...

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“…The incidence is approximately 1 per million per year [1,2]. Mortality is high and ranging between 12.5% and 22%, usually because of fatal hemorrhage [3][4][5][6]. Therefore, it is important to treat to induce remission.…”

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confidence: 99%

Antiphospholipid antibodies and antibodies to tissue factor pathway inhibitor in women with implantation failures or early and late pregnancy losses

Martinuzzo

Varela

Adamczuk

et al. 2005

Journal of Thrombosis and Haemostasis

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“…Taylor et al (3) found an elevated prevalence of anti-smooth muscle, anti-phospholipid, and anti-nuclear antibodies among patients with unexplained infertility, as compared to normal pregnant women. Roussev et al ( 4) reported about phospholipid antibodies as the most frequently abnormal result among a set of antibodies in women with reproductive failure; more specifically, these antibodies were found in 42% of women with unexplained infertility.…”

Section: Prevalence Of Anti-phospholipid Antibodies In Infertile Womenmentioning

confidence: 97%

Anti-phospholipid autoantibodies—do they have a pathogenic role in infertility?

Sherer

Shoenfeld

1998

Scandinavian Journal of Rheumatology

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“…Several clinical studies showed that ANA was related to adverse reproductive events, including recurrent spontaneous abortion, recurrent implantation failure, and infertility (2)(3)(4)(5)(6)(7)(8)(9). Additionally, ANA may exert adverse effects on the outcome of IVF-ET (2)(3)(4)(5)10).…”

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confidence: 99%