Anti-phospholipid autoantibodies—do they have a pathogenic role in infertility?

Sherer, Yaniv; Shoenfeld, Yehuda

doi:10.1080/03009742.1998.11720759

Cited by 8 publications

(5 citation statements)

References 24 publications

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“…On occasion there has been a reversal of opinion such that certain authors would appear both in favor of and against assigning a pathophysiologic role for aPL and implantation 28 . Having said that, the majority of published reports claim that the presence of aPL can have an adverse effect upon implantation 6,29–49 . This is not a universally held opinion, however, as several authors have not been able to document an association between aPL and implantation failure 7,50–57 …”

Section: Clinical Associations Of Apl With Infertility and In Vitro Fmentioning

confidence: 99%

Antiphospholipid Antibodies in Implantation Failures*

McIntyre

2003

American J Rep Immunol

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Section: Clinical Associations Of Apl With Infertility and In Vitro Fmentioning

confidence: 99%

Antiphospholipid Antibodies in Implantation Failures*

McIntyre

2003

American J Rep Immunol

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“…Thus, success rates among the patients in this study were not unusual. Some investigators claim that aPL reduces fertility, possibly by inducing abnormal morphology and developmental delay in embryos or by injuring preimplantation embryos and blastomeres (28). The same argument holds that mechanisms behind very early miscarriage or implantation failure in ART are similar (8).…”

Section: Discussionmentioning

confidence: 89%

Ovulation induction and in vitro fertilization in systemic lupus erythematosus and antiphospholipid syndrome

Guballa

Sammaritano

Schwartzman

et al. 2000

Arthritis & Rheumatism

142

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Objective. During ovulation induction (OI), ovarian stimulation is accomplished by hormonal manipulation, which includes administration of gonadotropins, gonadotropin-releasing hormone agonists, folliclestimulating hormone, and luteinizing hormone. In in vitro fertilization (IVF), progesterone is often added. Because of the possibility of hormone-associated flare or thrombosis, patients with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (primary APS) undergoing OI/IVF are potentially at increased risk. The present study was conducted in order to assess this risk.Methods. Nineteen women who underwent 68 cycles of OI/IVF were studied by interview and retrospective chart review.Results. Four OI/IVF cycles (25%) in SLE patients resulted in increased lupus activity and 2 (13%) in ovarian hyperstimulation syndrome. One patient with primary APS who was given heparin during multiple cycles developed osteopenia. No thrombosis occurred. Pregnancy complications included toxemia, lupus flare, gastrointestinal hemorrhage due to Mallory-Weiss tear, polygestation, and diabetes. Postpartum complications included nephritis flare, costochondritis, and suicidal depression. Lupus flares occurred at expected rates. Five of 16 cycles (31%) in 7 SLE patients, 5 of 48 cycles (10%) in 10 primary APS patients, and 0 of 5 cycles in 2 women with antiphospholipid antibody (without SLE or primary APS) resulted in liveborn children, including multiple gestations (3 twin sets with 4 surviving infants and 2 triplet sets with 3 surviving infants). Seven of 14 living children (50%) were premature, 3 had neonatal lupus, and 1 had pulmonic stenosis. Five surviving infants (38%) had complications unrelated to prematurity.Conclusion. Although OI/IVF can be successful in SLE and primary APS patients, rates of fetal and maternal complications are high.

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“…6,108,109 The main antiphospholipid antibodies are mainly targeted against cardiolipin, lupus anticoagulant, and b2-glycoprotein I antibodies. 6,108,109 The main antiphospholipid antibodies are mainly targeted against cardiolipin, lupus anticoagulant, and b2-glycoprotein I antibodies.…”

Section: How Vitamin D Impacts the Association Between Autoimmune Dmentioning

confidence: 99%

“…Antiphospholipid syndrome (APS) is one of the autoimmune disorders which is most linked to negative obstetric outcomes and RPL. 6,108,109 The main antiphospholipid antibodies are mainly targeted against cardiolipin, lupus anticoagulant, and b2-glycoprotein I antibodies. The incidence of those antibodies in recurrent miscarriages is considered to be between 15%-20%.…”

Section: How Vitamin D Impacts the Association Between Autoimmune Dmentioning

confidence: 99%

Vitamin D, autoimmunity and recurrent pregnancy loss: More than an association

Sharif

Watad

et al. 2018

American J Rep Immunol

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Recurrent pregnancy loss (RPL) affects close to 1% of couples; however, the etiology is known in only about 50% of the cases. Recent studies show that autoimmune dysregulation is a probable cause of RPL, which in some cases may be overlooked. In order for a pregnancy to proceed to term, early modulation of immunologic response is required to induce tolerance to the semi-allogenic fetus. Certain subsets of both the innate and adaptive immune responses play a role in the induction of fetomaternal tolerance. A relatively predominant T-cell helper (Th) 2 and T regulatory (Treg) cell population seem to favor a better pregnancy outcome, whereas Th1 and Th17 cell populations appear to have an opposite effect. Lately, the role of vitamin D in the modulation of immune response was established. Vitamin D has been shown to promote a more favorable environment for pregnancy through various mechanisms, such as enhancement of the shift toward Th2 cells and regulation of immune cell differentiation and cytokine secretion. Therefore, it seems that vitamin D deficiency sways the balance toward a worse outcome and may play a part in recurrent pregnancy loss. This review sheds light on the immunologic changes, which occur in early pregnancy and the regulatory role vitamin D has in the maintenance of this delicate balance.

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Anti-phospholipid autoantibodies—do they have a pathogenic role in infertility?

Cited by 8 publications

References 24 publications

Antiphospholipid Antibodies in Implantation Failures*

Antiphospholipid Antibodies in Implantation Failures*

Ovulation induction and in vitro fertilization in systemic lupus erythematosus and antiphospholipid syndrome

Vitamin D, autoimmunity and recurrent pregnancy loss: More than an association

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