Presence of anti-transcriptional intermediary factor-1 gamma antibodies in a dermatomyositis patient with retroperitoneal cancer of unknown primary site

Hori, Hiroshi; Ozeki, Yusuke; Kobashigawa, Tsuyoshi; Futsuhara, Kazushige; Watanabe, Eri; Yabe, Hiroki; Yago, Toru; Fukuchi, Takeo; Sugawara, Hitoshi; Kotake, Shigeru

doi:10.1080/24725625.2020.1789302

Cited by 2 publications

(1 citation statement)

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“…In case of anti-TIF1-gamma-positive DM, previous studies showed diagnosis of many types of cancers including breast cancer, squamous cell carcinoma of the skin, multiple myeloma, ovarian cancer, lymphoma, lung cancer and oesophageal cancer 4 11. More rare associations between malignancies and anti-TIF1-gamma-positive DM are also described in literature, for example, association with hepatocellular carcinoma,12 germ cell tumour,13 or cancer of unknown primary site 14. Interestingly, ovarian cancer is significantly more present in anti-TIF1-gamma-positive than anti-TIF1-gamma-negative patients: 19% vs 2%, respectively 5.…”

Section: Discussionmentioning

confidence: 96%

Paraneoplastic anti-TIF1-gamma-positive dermatomyositis as expression of cervical squamous cell carcinoma recurrence

van Erp,

Slaats,

Emmen

et al. 2024

BMJ Case Rep

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Idiopathic inflammatory myopathies are neuromuscular disorders characterised by muscle weakness and histologically inflammation within the muscle. Dermatomyositis and polymyositis are highly associated with a wide range of cancers, especially in antitranscriptional intermediary factor-1 (TIF1)-gamma-positive myositis. We present a case of paraneoplastic dermatomyositis in a patient with a medical history of a FIGO stage 1B1 cervical squamous cell carcinoma. Anti-TIF1-gamma autoantibodies were detected by myositis lineblot analysis and a PET-CT scan revealed an abnormality positioned at the right ovary. She underwent laparoscopic exploration and pathological analysis of the PET-positive abnormality showed a lymphogenic metastasis of a squamous cell carcinoma, competitive with cervical carcinoma recurrence. She started chemoradiation as curative oncological treatment. The dermatomyositis was successfully treated with high-dose corticosteroids. Physicians should be aware of the association between myositis and the increased risk of malignancies.

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