Presence of anti-DNA antibody in diabetes mellitus: Its relation to the duration of diabetes and diabetic complications

A clinical correlation of anti-DNA-AGE autoantibodies in type 2 diabetes mellitus with disease duration

“…Hyperglycemia, oxidative stress and increased production of AGEs contribute to the development of vascular complications, such as atherosclerosis, nephropathy and retinopathy in diabetes mellitus [9,10]. AntidsDNA autoantibodies in sera of type 1 and type 2 diabetes mellitus patients have been linked with duration and complications of the disease [11,12]. Furthermore, studies have shown that autoantibodies can predict both likelihood of clinical disease and the rate of progression [13].…”

Antinuclear antibodies define a subgroup of paraneoplastic neuropathies: clinical and immunological data

“…12 However, low titre ANA have not only been found in 2-6% of healthy people, but also in other organ specific autoimmune diseases such as autoimmune thyroid disease, multiple sclerosis, and autoimmune diabetes. [13][14][15][16] In recent years, an increased prevalence of ANA has also been reported in patients with tumours who do not have signs of rheumatic disease or vasculitis. 10 17 However, the ANA titres reported in these studies, including our previous study on non-small cell lung cancers, are much lower than those in the patients in our present study.…”

Study of Biochemical Parameters in Sera of Diabetes Mellitus DM (Type 1) Patients with Nephropathy and Myocardial Vascular Disease Complication

“…Enzymatic determination of urea concentration (urease -modified Berthelot eactionr [17], urease hydrolysis urea by product ammonium: according to Scheme (4 …”

“…Type I (insulin-dependent) diabetes mellitus is caused by an autoimmune process that leads to inappropriate inflammation directed at the pancreatic islets [2] it fact that Type I diabetes results from an autoimmune disease tells us that beta-cell destruction can be stopped by arresting the inflammatory autoimmune process [3]. Anti-DNA antibodies were found in the sera of diabetes mellitus patients and their presence was also related to the duration of diabetes mellitus and its complications [4] Anti single strand DNA antibodies were also found in the sera of the patients of type 1 diabetes mellitus [5]. Diabetes produces disturbances of lipid profiles, especially an increased susceptibility to lipid peroxidation [6] which is responsible for increase incidence of atherosclerosis [7].a major complication of diabetes mellitus [8].…”