Presence of a newly described human DNA virus (TTV) in patients with liver disease

Naoumov, Nikolai V.; Petrova, Elena P; Thomas, Mark G.; Williams, Roger

doi:10.1016/s0140-6736(98)04069-0

Cited by 284 publications

(237 citation statements)

References 11 publications

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“…The high prevalence of active TTV infection in the general population, both in the UK and in Japan, and the lack of significant liver damage, suggest that TTV, similar to hepatitis G virus (HGV), may be an example of a human virus with no clear disease association. [29][30][31] However, there are no available data regarding TTV in the HAAA group. In the group of HAAA patients reported here, TTV was not detected, suggesting that TTV is not a major etiological agent for HAAA.…”

Section: Discussionmentioning

confidence: 99%

Lack of known hepatitis virus in hepatitis-associated aplastic anemia and outcome after bone marrow transplantation

Safadi

Ilan

et al. 2001

Bone Marrow Transplant

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Summary:Viral infection has been shown to induce aplastic anemia, unidentified types of hepatitis being the most common cause for aplastic anemia-associated viral hepatitis. The survival rate for this group of patients after bone marrow transplantation with stem cells from an HLAmatched sibling is not well known. The aim of this study was to determine the prevalence of hepatitis G virus (HGV) and transfusion transmitted virus (TTV) infection in non-A, non-B, non-C hepatitis associated-aplastic anemia (HAAA) patients, and to define the role of bone marrow transplantation (BMT) as a therapeutic modality for this disease.

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Section: Discussionmentioning

confidence: 99%

Lack of known hepatitis virus in hepatitis-associated aplastic anemia and outcome after bone marrow transplantation

Safadi

Ilan

et al. 2001

Bone Marrow Transplant

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“…Hence, TTV is an exceedingly common, globally distributed agent. 2,4,5 In the United States, the rate of viremia far exceeds that for HCV (0.3%), HBV (0.1%), and HGV (1.5%). It is clear that TTV is parenterally transmitted.…”

Section: Discussionmentioning

confidence: 99%

Transfusion-associated TT virus infection and its relationship to liver disease

et al. 1999

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TT virus (TTV) has been proposed as the causative agent of non-A to E hepatitis. We studied the association between TTV viremia and biochemical evidence of hepatitis in blood donors and prospectively-followed patients. TTV was found in 7.5% of 402 donors and in 11.0% of 347 patients before transfusion. The rate of new TTV infections was 4.7% in 127 nontransfused, and 26.4% in 182 transfused patients (P F .0001). The risk of infection increased with the number of units transfused (P F .0001). The rate of new TTV infections in 13 patients with non-A to E hepatitis (23.2%) was almost identical to the rate in 124 patients who were transfused, but did not develop hepatitis (21.8%). Of 45 patients with acute hepatitis C, 40.0% were simultaneously infected with TTV. TTV did not worsen the biochemical severity (mean ALT: 537 in TTV؉; 550 in TTV؊) or persistence of hepatitis C. In non-A to E cases, the mean ALT was 182 in those TTV-positive and 302 in TTV-negatives. No consistent relationship between alanine transaminase level and TTV DNA level was observed in 4 patients with long-term, sequential samples. Of 21 viremic subjects, 67% cleared TTV within 5 years (38% in 1 year); 33% were viremic throughout follow-up extending to 22 years. We conclude that TTV is a very common, often persistent infection that is transmitted by transfusion and by undefined nosocomial routes. We found no association between TTV and non-A to E hepatitis and no effect of TTV on the severity or duration of coexistent hepatitis C. TTV may not be a primary hepatitis virus. (HEPATOLOGY 1999;30:283-288.)TT virus (TTV) was discovered in 1997 by representational difference analysis of serial serum specimens from Japanese patients with transfusion-associated non-A to G hepatitis. 1 Because of a temporal association between TTV viremia and elevations in serum alanine transaminase (ALT) level in 3 of 5 patients studied, TTV was proposed as the causative agent of non-A to G hepatitis. 1 TTV was initially described as a single-stranded DNA virus of approximately 3,800 base pairs (bp) and considered to be a member of the parvovirus family. 2 A subsequent analysis suggested that it was a single-stranded circular DNA virus in the circovirus family. 3 These genomic characterizations have been questioned and, at present, the agent has not been definitively classified. Seroepidemiological studies have shown TTV to have global distribution. 2,[4][5][6] Although the potential association of TTV with cryptogenic hepatitis is intriguing, the pathological and clinical significance of this virus remains to be established. To assess more fully the etiological role of TTV in the causation of hepatitis, we determined the frequency of acute TTV infections and their relationship to hepatitis in a cohort of prospectivelyfollowed transfusion recipients who did and did not develop hepatitis and in nontransfused controls. Prevalence of the agent was assessed in blood donors and in patients at the time of hospital admission. MATERIALS AND METHODS Selection of Patients in Variou...

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“…1 TTV was successfully detected in serum and liver tissues of patients with acute and chronic liver diseases. [1][2][3] TTV-associated posttransfusion hepatitis was found among patients undergoing surgery with blood transfusion. 4 TTV contamination was found in a high proportion of blood products.…”

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confidence: 99%

A case-control study on a novel DNA virus (TT virus) infection and hepatocellular carcinoma

Tagger¹,

Donato²,

Ribero³

et al. 1999

Hepatology

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We performed a case-control study to evaluate the association of a new human DNA virus named TT virus (TTV) with hepatocellular carcinoma (HCC). We recruited 174 subjects hospitalized for HCC (84% males; mean age: 64 years) and 118 patients hospitalized for non-liver diseases in Brescia, northern Italy, as controls (94% males; mean age: 66 years). TTV DNA was found in serum by polymerase chain reaction (PCR) in 26 cases (15%) and 11 controls (9.3%) (P G .1). TTV group 2 infection was identified in 16 cases (61.5%) and 4 controls (36.4%) (P G .1) using a type-specific PCR method. Sequence analysis of 222 nt of TTV DNA demonstrated that the remaining 10 cases and 7 controls were all infected by group 1. The odds ratio (

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Presence of a newly described human DNA virus (TTV) in patients with liver disease

Cited by 284 publications

References 11 publications

Lack of known hepatitis virus in hepatitis-associated aplastic anemia and outcome after bone marrow transplantation

Lack of known hepatitis virus in hepatitis-associated aplastic anemia and outcome after bone marrow transplantation

Transfusion-associated TT virus infection and its relationship to liver disease

A case-control study on a novel DNA virus (TT virus) infection and hepatocellular carcinoma

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