A case-control study on a novel DNA virus (TT virus) infection and hepatocellular carcinoma

Tagger, A.; Donato, Francesco; Ribero, M.L.; Binelli, Giorgio; Gelatti, Umberto; Portera, Giuseppe; Albertini, Alberto; Fasola, Michele; Chiesa, Roberta; Nardi, Giuseppe

doi:10.1002/hep.510300115

Cited by 40 publications

(19 citation statements)

References 27 publications

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“…Since the first isolation of TTV, most studies have shown that it might be relevant to liver disorders and liver damage and have a possible association with fulminant hepatitis, cryptogenic liver disease, non-A-G hepatitis, posttransfusion hepatitis, liver cirrhosis, and hepatocellular carcinoma (11,22,37,41,57,65). At the same time, epidemiological associations of TTV with B-cell lymphoma, Hodgkin's disease, aplastic anemia, idiopathic pulmonary fibrosis, acute respiratory disease, and autoimmune rheumatic disorders have also been described (6,16,29,30,32,52).…”

mentioning

confidence: 99%

Torque Teno Virus (SANBAN Isolate) ORF2 Protein Suppresses NF-κB Pathways via Interaction with IκB Kinases

Zheng

Fang

et al. 2007

J Virol

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mentioning

confidence: 99%

Torque Teno Virus (SANBAN Isolate) ORF2 Protein Suppresses NF-κB Pathways via Interaction with IκB Kinases

Zheng

Fang

et al. 2007

J Virol

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“…Contrasting that, another group reported TTV-DNA to occur more frequently in patients with liver cirrhosis and HCC than in those with chronic hepatitis [27] . Using a case-control study to compare the prevalence of 174 Italian patients and matched controls, it was demonstrated that individuals infected with TTV did not exhibit an increased relative risk for developing HCC [90] . Furthermore, it has been demonstrated that the TTV genome is not found integrated into host hepatocyte DNA [91] , the one process that might represent a potential risk factor in the development of HCC.…”

Section: Ttv Infection In Liver Diseasesmentioning

confidence: 99%

Transfusion transmitted virus: A review on its molecular characteristics and role in medicine

Irshad¹,

Yk²,

Dhar³

2006

WJG

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The present review gives an updated overview of transfusion transmitted virus (TTV), a novel agent, in relation to its molecular characteristics, epidemiological features, modes of transmission, tissue tropism, pathogenesis, role in various diseases and its eradication from the body. TTV, a DNA virus, is a single stranded, non-enveloped, 3.8 kb long DNA virus with a small and covalently closed circular genome comprising 3852 bases. It was tentatively designated Circinoviridae virus.TTV genome sequence is heterogeneous and reveals the existence of six different genotypes and several subtypes. TTV has been reported to transmit not only via parenteral routes, but also via alternate routes. This virus has been detected in different non-human primates as well. At present, TTV is detected by polymerase chain reaction (PCR) with no other available diagnostic assays. It shows its presence globally and was detected in high percent populations of healthy persons as well as in various disease groups. Initially it was supposed to have strong association with liver disease; however, there is little evidence to show its liver tropism and contribution in causing liver diseases. It shows high prevalence in hemodialysis patients, pointing towards its significance in renal diseases. In addition, TTV is associated with several infectious and non-infectious diseases. Although its exact pathogenesis is not yet clear, TTV virus possibly resides and multiplies in bone marrow cells and peripheral blood mononuclear cells (PBMCs). Recently, attempts have been made to eradicate this virus with interferon treatment. More information is still needed to extricate various mysteries related to TTV.

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“…Furthermore, retrospective analyses of patients treated with alpha interferon with or without ribavirin for underlying HCV infection have shown that therapy may result in a generally transient disappearance of detectable TTV from blood, especially if baseline TTV viremia is low, but that this is not accompanied by modulation of ALT levels unless HCV is also cleared (4,8,16,48). In addition, attempts to link TTV to hepatocellular carcinoma in patients positive or negative for HBV and HCV have given inconsistent results (107,132,156,184). Undoubtedly, the above observations rule out the notion that clinically evident liver disease is a frequent consequence of TTV infection.…”

Section: Clinical Significancementioning

confidence: 99%

Molecular Properties, Biology, and Clinical Implications of TT Virus, a Recently Identified Widespread Infectious Agent of Humans

et al. 2001

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TT virus (TTV) was first described in 1997 by representational difference analysis of sera from non-A to non-G posttransfusion hepatitis patients and hence intensively investigated as a possible addition to the list of hepatitis-inducing viruses. The TTV genome is a covalently closed single-stranded DNA of approximately 3.8 kb with a number of characteristics typical of animal circoviruses, especially the chicken anemia virus. TTV is genetically highly heterogeneous, which has led investigators to group isolates into numerous genotypes and subtypes and has limited the sensitivity of many PCR assays used for virus detection. The most remarkable feature of TTV is the extraordinarily high prevalence of chronic viremia in apparently healthy people, up to nearly 100% in some countries. The original hypothesis that it might be an important cause of cryptogenic hepatitis has not been borne out, although the possibility that it may produce liver damage under specific circumstances has not been excluded. The virus has not yet been etiologically linked to any other human disease. Thus, TTV should be considered an orphan virus

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A case-control study on a novel DNA virus (TT virus) infection and hepatocellular carcinoma

Cited by 40 publications

References 27 publications

Torque Teno Virus (SANBAN Isolate) ORF2 Protein Suppresses NF-κB Pathways via Interaction with IκB Kinases

Torque Teno Virus (SANBAN Isolate) ORF2 Protein Suppresses NF-κB Pathways via Interaction with IκB Kinases

Transfusion transmitted virus: A review on its molecular characteristics and role in medicine

Molecular Properties, Biology, and Clinical Implications of TT Virus, a Recently Identified Widespread Infectious Agent of Humans

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