Prescription patterns of traditional Chinese medicine for peptic ulcer disease in Taiwan: A nationwide population-based study

Huang, Chin-Ying; Lai, W. Michael; Sun, Mao-Feng; Lin, Chun‐Pin; Chen, Bor-Chyuan; Lin, Hung‐Jen; Chang, Ching-Ter; Yang, Chi; Huang, Kuo‐Tung; Yen, Hung-Rong

doi:10.1016/j.jep.2015.11.002

Cited by 29 publications

(22 citation statements)

References 46 publications

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“…We found that the highest TCM utilization rate was young people. Several surveys also showed similar findings [14, 32]; women and younger people had a higher usage of TCM. There was also a tendency for TCM users to reside in higher urbanized area.…”

Section: Discussionsupporting

confidence: 56%

“…This study used datasets from the NHIRD (http://nhird.nhri.org.tw/en/) in Taiwan as our previous reports [14, 18]. The NHI program in Taiwan reimbursed TCM services (CHM, acupuncture/moxibustion, and Chinese traumatology therapy) provided by licensed TCM doctors.…”

Section: Methodsmentioning

confidence: 99%

“…It has been commonly used for dermatitis [13], gastrointestinal disease [14], rheumatoid arthritis [15], diabetic mellitus [16, 17], gynecological disorder [18], and cancer [19, 20] patients. Previous studies showed that CHM plus acitrerin had add-on effect [21] and Chinese herbal bath combined with phototherapy was superior to phototherapy alone [22] for psoriasis.…”

Section: Introductionmentioning

confidence: 99%

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Traditional Chinese Medicine Use among Patients with Psoriasis in Taiwan: A Nationwide Population-Based Study

Weng

Chen²,

Wang

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Traditional Chinese medicine (TCM) has long been used for patients with psoriasis. This study aimed to investigate TCM usage in patients with psoriasis. We analyzed a cohort of one million individuals representing the 23 million enrollees randomly selected from the National Health Insurance Research Database in Taiwan. We identified 28,510 patients newly diagnosed with psoriasis between 2000 and 2010. Among them, 20,084 (70.4%) patients were TCM users. Patients who were female, younger, white-collar workers and lived in urbanized area tended to be TCM users. The median interval between the initial diagnosis of psoriasis to the first TCM consultation was 12 months. More than half (N = 11,609; 57.8%) of the TCM users received only Chinese herbal medicine. Win-qing-yin and Bai-xian-pi were the most commonly prescribed Chinese herbal formula and single herb, respectively. The core prescription pattern comprised Mu-dan-pi, Wen-qing-yin, Zi-cao, Bai-xian-pi, and Di-fu-zi. Patients preferred TCM than Western medicine consultations when they had metabolic syndrome, hepatitis, rheumatoid arthritis, alopecia areata, Crohn's disease, cancer, depression, fatty liver, chronic airway obstruction, sleep disorder, and allergic rhinitis. In conclusion, TCM use is popular among patients with psoriasis in Taiwan. Future clinical trials to investigate its efficacy are warranted.

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Section: Discussionsupporting

confidence: 56%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Traditional Chinese Medicine Use among Patients with Psoriasis in Taiwan: A Nationwide Population-Based Study

Weng

Chen²,

Wang

et al. 2016

Evidence-Based Complementary and Alternative Medicine

Self Cite

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“…One of the possibilities is that there was limited clinical evidence to report the efficacy of TCM in the treatment of AD. However, our previous studies found that elderly patients had poor compliance and a lower utilization rate of TCM .…”

Section: Discussionmentioning

confidence: 86%

Utilization of Western medicine and traditional Chinese medicine among patients with Alzheimer's disease in Taiwan: a nationwide population‐based study

Lai

Chiang

et al. 2017

Euro J of Neurology

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“…BXXXT has been widely used in TCM clinical practice. Previous studies [ 20 , 21 ] have illustrated that BXXXT possesses anti-inflammatory activities, and it can be used for the treatments of various digestive inflammations such as colitis, esophagitis, and gastritis [ 20 , 22 ]. On the other hand, multiple and diverse indications that extend the applications of original context were reported for the use of BXXXT.…”

Section: Introductionmentioning

confidence: 99%

A Network Pharmacology Approach to Uncover the Molecular Mechanisms of Herbal Formula Ban-Xia-Xie-Xin-Tang

Yang

Chen

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Ban-Xia-Xie-Xin-Tang (BXXXT) is a classical formula from Shang-Han-Lun which is one of the earliest books of TCM clinical practice. In this work, we investigated the therapeutic mechanisms of BXXXT for the treatment of multiple diseases using a network pharmacology approach. Here three BXXXT representative diseases (colitis, diabetes mellitus, and gastric cancer) were discussed, and we focus on in silico methods that integrate drug-likeness screening, target prioritizing, and multilayer network extending. A total of 140 core targets and 72 representative compounds were finally identified to elucidate the pharmacology of BXXXT formula. After constructing multilayer networks, a good overlap between BXXXT nodes and disease nodes was observed at each level, and the network-based proximity analysis shows that the relevance between the formula targets and disease genes was significant according to the shortest path distance (SPD) and a random walk with restart (RWR) based scores for each disease. We found that there were 22 key pathways significantly associated with BXXXT, and the therapeutic effects of BXXXT were likely addressed by regulating a combination of targets in a modular pattern. Furthermore, the synergistic effects among BXXXT herbs were highlighted by elucidating the molecular mechanisms of individual herbs, and the traditional theory of “Jun-Chen-Zuo-Shi” of TCM formula was effectively interpreted from a network perspective. The proposed approach provides an effective strategy to uncover the mechanisms of action and combinatorial rules of BXXXT formula in a holistic manner.

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Prescription patterns of traditional Chinese medicine for peptic ulcer disease in Taiwan: A nationwide population-based study

Cited by 29 publications

References 46 publications

Traditional Chinese Medicine Use among Patients with Psoriasis in Taiwan: A Nationwide Population-Based Study

Traditional Chinese Medicine Use among Patients with Psoriasis in Taiwan: A Nationwide Population-Based Study

Utilization of Western medicine and traditional Chinese medicine among patients with Alzheimer's disease in Taiwan: a nationwide population‐based study

A Network Pharmacology Approach to Uncover the Molecular Mechanisms of Herbal Formula Ban-Xia-Xie-Xin-Tang

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