Utilization of Western medicine and traditional Chinese medicine among patients with Alzheimer's disease in Taiwan: a nationwide population‐based study

Lai, Chun-Ting; Wu, Mingyue; Chiang, Jen Huai; Sun, Mao-Feng; Chen, Y.-H.; Chang, Ching-Ter; Lin, Jaung Geng; Yen, Hung-Rong

doi:10.1111/ene.13361

Cited by 17 publications

(10 citation statements)

References 36 publications

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“…The NHI program covers not only Western medical services but also ambulatory care in TCM. All claims data from the NHI program are collected in the National Health Insurance Research Database (NHIRD), and researchers can use these datasets to evaluate the utilization of TCM for various diseases such as allergies [ 14 , 15 ], musculoskeletal diseases [ 16 – 18 ], metabolic disorders [ 19 , 20 ], gynecologic diseases [ 21 ], pediatric diseases [ 2 ], geriatric disorders [ 22 ] and cancer [ 23 , 24 ]. De-identified demographic characteristics (e.g., sex, date of birth, occupation and place of residence) and clinical information (e.g., diagnosis, management and treatment) are also provided in the database.…”

Section: Introductionmentioning

confidence: 99%

Trends in use of acupuncture among adults in Taiwan from 2002 to 2011: A nationwide population-based study

Lee

Lin

et al. 2018

PLoS ONE

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In recent years, acupuncture has gained in popularity worldwide. However, recent epidemiological studies are lacking. We conducted this study to investigate the trends in acupuncture utilization among adults in Taiwan from 2002 to 2011. We analyzed data from the Longitudinal Health Insurance Database 2000 (LHID 2000), which contains all original claims data for 1 million beneficiaries randomly sampled from the registry of all beneficiaries enrolled in the National Health Insurance (NHI) program in 2000. The one-year prevalence of acupuncture use among adults increased from 7.98% in 2002 to 10.9% in 2011. Acupuncture use significantly increased yearly (incidence rate ratio = 1.04, 95% CI = 1.03−1.05, p<0.001). Patients who were female, were middle-aged, resided in highly urbanized areas and suffered from injury or disorders of the musculoskeletal system were prone to more frequent acupuncture use. Our study revealed that the utilization of acupuncture became increasingly popular in Taiwan from 2002 to 2011. Our findings may provide useful information for clinical practice and research as well as for health policy decision making.

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Section: Introductionmentioning

confidence: 99%

Trends in use of acupuncture among adults in Taiwan from 2002 to 2011: A nationwide population-based study

Lee

Lin

et al. 2018

PLoS ONE

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“…More than 25% of residents in Taiwan use both Chinese and Western medicines [29]. Furthermore, elderly patients aged > 65 years and those with Alzheimer’s disease [30] are usually prescribed more than three different medicines, and progressive impairment in the functional reserve of multiple organs may affect pharmacokinetics or pharmacodynamics during aging [31]. Therefore, the vulnerability of the elderly to problems related to drug use is increasing [32].…”

Section: Discussionmentioning

confidence: 99%

Constructing a bilingual website with validated database for Herb and Western medicine interactions using Ginseng, Ginkgo and Dong Quai as examples

Chen

et al. 2019

BMC Complement Altern Med

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BackgroundConcerns have been raised regarding the efficacy and safety resulting from the potential interactions of herbs with Western medications due to the use of both herbs and Western medicine by the general public. Information obtained from the web must be critically evaluated prior to its use in making decisions.DescriptionThis study aimed to construct an herb-drug interaction (HDI) website (https://drug-herb-interaction.netlify.com) with a critically reviewed database. Node.js was used to store the database by running JavaScript. Vue.js is a front-end framework used for web interface development. A total of 135 sets of information related to the interactions of ginseng, ginkgo and dong quai with Western medicine from the literature identified in Medline were collected, followed by critical reviews to prepare nineteen items of information for each HDI monograph. A total of 80 sets of validated HDIs met all criteria and were further assessed at the individual reliability level (likely, possible, and unevaluable) and labeled with the “interaction” item. This query system of the website can be operated in both the Chinese and English languages to obtain all monographs on HDIs in the database, including bilingual interaction data. The database of HDI monographs can be updated by simply uploading a new version of the information Excel file. The designed “smart search” module, in addition to the “single search”, is convenient for requesting multiple searches. Among the “likely” interactions (n = 26), 50% show negative HDIs. Ten of these can increase the effect of the Western drug, and the others (n = 3) imply that the HDI can be beneficial.ConclusionsThe current study provides a website platform and 80 sets of validated bilingual HDIs involving ginseng, ginkgo and dong quai in an online database. A search of HDI monographs related to these three herbs can be performed with this bilingual, easy-to-use query website, which is feasible for professionals and the general public. The identified reliability level for each HDI may assist readers’ decisions regarding whether taking Western medications concomitant with one of three herbal medicinal foods is safe or whether caution is required due to potentially serious outcomes.

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“…Due to the complex pathology of AD, drugs targeting single protein or pathway may not fully exert expected therapeutic effects. TCM formulae, along with network pharmacology approaches, provide a powerful tool to investigate AD pathology, and they are also promising outsets for anti-AD drug development ( Dey et al, 2017 ; Lai et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

A Computational Systems Pharmacology Approach to Investigate Molecular Mechanisms of Herbal Formula Tian-Ma-Gou-Teng-Yin for Treatment of Alzheimer’s Disease

Wang

Sun

et al. 2018

Front. Pharmacol.

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Traditional Chinese medicine (TCM) is typically prescribed as formula to treat certain symptoms. A TCM formula contains hundreds of chemical components, which makes it complicated to elucidate the molecular mechanisms of TCM. Here, we proposed a computational systems pharmacology approach consisting of network link prediction, statistical analysis, and bioinformatics tools to investigate the molecular mechanisms of TCM formulae. Taking formula Tian-Ma-Gou-Teng-Yin as an example, which shows pharmacological effects on Alzheimer’s disease (AD) and its mechanism is unclear, we first identified 494 formula components together with corresponding 178 known targets, and then predicted 364 potential targets for these components with our balanced substructure-drug–target network-based inference method. With Fisher’s exact test and statistical analysis we identified 12 compounds to be most significantly related to AD. The target genes of these compounds were further enriched onto pathways involved in AD, such as neuroactive ligand–receptor interaction, serotonergic synapse, inflammatory mediator regulation of transient receptor potential channel and calcium signaling pathway. By regulating key target genes, such as ACHE, HTR2A, NOS2, and TRPA1, the formula could have neuroprotective and anti-neuroinflammatory effects against the progression of AD. Our approach provided a holistic perspective to study the relevance between TCM formulae and diseases, and implied possible pharmacological effects of TCM components.

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Utilization of Western medicine and traditional Chinese medicine among patients with Alzheimer's disease in Taiwan: a nationwide population‐based study

Abstract: This study revealed the specific usage patterns of TCM and non-TCM medical services among patients with AD. The information could be used for improving the healthcare of patients with AD.

Cited by 17 publications

References 36 publications

Trends in use of acupuncture among adults in Taiwan from 2002 to 2011: A nationwide population-based study

Trends in use of acupuncture among adults in Taiwan from 2002 to 2011: A nationwide population-based study

Constructing a bilingual website with validated database for Herb and Western medicine interactions using Ginseng, Ginkgo and Dong Quai as examples

A Computational Systems Pharmacology Approach to Investigate Molecular Mechanisms of Herbal Formula Tian-Ma-Gou-Teng-Yin for Treatment of Alzheimer’s Disease

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