Prepulse inhibition of acoustic startle in Japanese patients with chronic schizophrenia

Possible role of the dopamine D1 receptor in the sensorimotor gating deficits induced by high-fat diet

“…Reduced PPI of acoustic startle has been associated with schizophrenia (Braff et al 1978). Previously, we confirmed PPI deficits in a population of Japanese patients with schizophrenia (Kunugi et al 2007). Further, two spontaneously obese rodent strains, the db/db mouse and the Zucker fatty rat, have a point mutation in the leptin receptor gene as well as cognitive deficits (Li et al 2002;Winocur et al 2005).…”

Behavioral and molecular evidence for psychotropic effects in l-theanine

“…To our knowledge, this study is the first to provide evidence for the effects of Ltheanine on sensorimotor gating. Impaired sensorimotor gating as indicated by decreased PPI is a feature of patients with schizophrenia Kunugi et al 2007). …”

“…It has been widely accepted that deficits in PPI of acoustic startle indicate impairment of sensorimotor gating and occur in patients with schizophrenia Kunugi et al 2007). Competitive and non-competitive NMDA receptor antagonists (e.g., phencyclidine,, and ketamine) produce robust deficits in PPI in rodents (Geyer 2006;Geyer et al 2001;Kretschmer and Koch 1997;Mansbach and Geyer 1989).…”

Effect of aripiprazole, risperidone, and olanzapine on the acoustic startle response in Japanese chronic schizophrenia

“…These abnormalities are also considered to be endophenotypes for schizophrenia (Braff et al 1992;Kunugi et al 2007;Takahashi et al 2008;Walters and Owen 2007). Recently, we detected significant differences in ASR, HAB, and each PPI (82, 86, and 90 dB) between patients with schizophrenia and controls (Moriwaki et al 2009).…”

“…Disruption of the sensorimotor gating system, including prepulse inhibition (PPI) deficit, the acoustic startle reflex (ASR), and habituation (HAB), is suggested to be one of involved in the pathophysiology of schizophrenia (Braff et al 1992;Kunugi et al 2007;Takahashi et al 2008;Walters and Owen 2007). These abnormalities are also considered to be endophenotypes for schizophrenia (Braff et al 1992;Kunugi et al 2007;Takahashi et al 2008;Walters and Owen 2007).…”