Effect of aripiprazole, risperidone, and olanzapine on the acoustic startle response in Japanese chronic schizophrenia

Kishi, Taro; Moriwaki, Masatsugu; Kitajima, Tsuyoshi; Kawashima, Koichiro; Okochi, Tomo; Fukuo, Yasuhisa; Furukawa, Osamu; Naitoh, Hiroshi; Fujita, Kiyoshi; Iwata, Nakao

doi:10.1007/s00213-010-1787-x

Cited by 7 publications

(3 citation statements)

References 24 publications

(40 reference statements)

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“…Disruption of PPI in rats is at least partly due to activation of D 2 r (Swerdlow et al, 1991), suggesting that increased activity at these receptors might also be a substrate for PPI deficits in schizophrenia. In this sense, patients with schizophrenia present significant differences in the acoustic startle reflex, habituation to startle stimuli, and several PPI levels compared with healthy controls (Moriwaki et al, 2009), and antipsychotic treatment with olanzapine, aripiprazole, and risperidone improve PPI, but do not modify the acoustic startle reflex or habituation (Kishi et al, 2010;Wynn et al, 2007). Another study using a longitudinal within-subjects design reported improved results after switching from the conventional antipsychotic zuclopenthixol to long-acting injectable risperidone (Martinez-Gras et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Deletion of CB2 Cannabinoid Receptor Induces Schizophrenia-Related Behaviors in Mice

Ortega-Álvaro

Aracil-Fernández

García-Gutiérrez

et al. 2011

Neuropsychopharmacol

178

134

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The possible role of the CB 2 receptor (CB 2 r) in psychiatric disorders has been considered. Several animal models use knockout (KO) mice that display schizophrenia-like behaviors and this study evaluated the role of CB 2 r in the regulation of such behaviors. Mice lacking the CB 2 r (CB 2 KO) were challenged in open field, light-dark box, elevated plus-maze, tail suspension, step down inhibitory avoidance, and pre-pulse inhibition tests (PPI). Furthermore, the effects of treatment with cocaine and risperidone were evaluated using the OF and the PPI test. Gene expression of dopamine D 2 (D 2 r), adrenergic-a 2C (a 2C r), serotonergic 5-HT 2A and 5-HT 2C receptors (5-HT 2A r and 5-HT 2C r) were studied by RT-PCR in brain regions related to schizophrenia. Deletion of CB 2 r decreased motor activity in the OF test, but enhanced response to acute cocaine and produced mood-related alterations, PPI deficit, and cognitive impairment. Chronic treatment with risperidone tended to impair PPI in WT mice, whereas it 'normalized' the PPI deficit in CB 2 KO mice. CB 2 KO mice presented increased D 2 r and a 2C r gene expressions in the prefrontal cortex (PFC) and locus coeruleus (LC), decreased 5-HT 2C r gene expression in the dorsal raphe (DR), and 5-HT 2A r gene expression in the PFC. Chronic risperidone treatment in WT mice left a 2C r gene expression unchanged, decreased D 2 r gene expression (15 mg/kg), and decreased 5-HT 2C r and 5-HT 2A r in PFC and DR. In CB 2 KO, the gene expression of D 2 r in the PFC, of a 2C r in the LC, and of 5-HT 2C r and 5-HT 2A r in PFC was reduced; 5-HT 2C r and 5-HT 2A r gene expressions in DR were increased after treatment with risperidone. These results suggest that deletion of CB 2 r has a relation with schizophrenia-like behaviors. Pharmacological manipulation of CB 2 r may merit further study as a potential therapeutic target for the treatment of schizophrenia-related disorders.

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Section: Discussionmentioning

confidence: 99%

Deletion of CB2 Cannabinoid Receptor Induces Schizophrenia-Related Behaviors in Mice

Ortega-Álvaro

Aracil-Fernández

García-Gutiérrez

et al. 2011

Neuropsychopharmacol

178

134

View full text Add to dashboard Cite

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“…Numerous studies have provided evidence that PPI deficits in patients with schizophrenia are improved by antipsychotics,24,37,38,40,42,59-67) in particular atypical antipsychotics, which appear to have a close association with PPI improvement in schizophrenia 24,42,59-61,63,64,66,68-70). Although PPI has been reported in association with positive symptoms65,71) and negative symptoms,71,72) thought disorders73) and social perception74) of schizophrenia, most studies do not support a link between PPI and psychiatric symptoms 24,63,70,75).…”

Section: Ppi In Schizophreniamentioning

confidence: 99%

Prepulse Inhibition of Startle Response: Recent Advances in Human Studies of Psychiatric Disease

Takahashi

Hashimoto

Iwase

et al. 2011

Clin Psychopharmacol Neurosci

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Prepulse inhibition (PPI) is considered to be one of the most promising neurophysiological indexes for translational research in psychiatry. Impairment of PPI has been reported in several psychiatric diseases, particularly schizophrenia, where PPI is considered a candidate intermediate phenotype (endophenotype) of the disease. Recent findings from a variety of research areas have provided important evidence regarding PPI impairment. Human brain imaging studies have demonstrated the involvement of the striatum, hippocampus, thalamus and frontal and parietal cortical regions in PPI. In addition, several genetic polymorphisms, including variations in the genes coding for Catechol O-methyltransferase, Neuregulin 1, nuclear factor kappa-B subunit 3 and serotonin-2A receptor were related to PPI; and these findings support PPI as a polygenetic trait that involves several neurotransmitter pathways. Early psychosis studies suggest that PPI disruption is present before the onset of psychosis. Also, discrepancy of PPI impairment between children and adults can be found in other psychiatric diseases, such as autistic spectrum disorders and posttraumatic stress disorder, and comprehensive investigation of startle response might contribute to understand the impairment of the neural circuitry in psychiatric diseases. Finally, recent studies with both Asian and Caucasian subjects indicate that patients with schizophrenia exhibit impaired PPI, and impaired sensorimotor gating might be a global common psychophysiological feature of schizophrenia. In conclusion, studies of PPI have successfully contributed to a better understanding of the fundamental neural mechanisms underlying sensorimotor gating and will certainly be most valuable in devising future approaches that aim to investigate the complex pathogenesis of psychiatric diseases.

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“…However, these agents tended to be prescribed in low doses, usually with a tapering schedule until discontinuation. Only patients prescribed antipsychotic were excluded, because these agents are known to influence SRs and PPI (Martinez-Gras et al, 2009;Kishi et al, 2010).…”

Section: Patientsmentioning

confidence: 99%

Startle-Response Based Tasks and Laboratory Measures of Impulsivity in Abstinent Alcoholic Patients

Marín

Jurado

Ponce

et al. 2015

Alcohol and Alcoholism

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Effect of aripiprazole, risperidone, and olanzapine on the acoustic startle response in Japanese chronic schizophrenia

Abstract: Aripiprazole and risperidone may improve PPI90. ASR, HAB, PPI82, and PPI86 were no different among the Japanese schizophrenic patient groups with different antipsychotics.

Cited by 7 publications

References 24 publications

Deletion of CB2 Cannabinoid Receptor Induces Schizophrenia-Related Behaviors in Mice

Deletion of CB2 Cannabinoid Receptor Induces Schizophrenia-Related Behaviors in Mice

Prepulse Inhibition of Startle Response: Recent Advances in Human Studies of Psychiatric Disease

Startle-Response Based Tasks and Laboratory Measures of Impulsivity in Abstinent Alcoholic Patients

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