Preprocedural red blood cell distribution width predicts bare metal stent restenosis

Yıldız, Atilla; Tekiner, Fatih; Karakurt, Ahmet; Şirin, Gökçe; Duman, Dursun

doi:10.1097/mca.0000000000000105

Cited by 12 publications

(10 citation statements)

References 32 publications

(38 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…37 In a recent study, an increased RDW predicted BMS restenosis suggesting potential as a useful screening tool to stratify patients by higher or lower risk of ISR. 38 The underlying mechanism of the relationship between RDW and DES restenosis remains undefined. In the present study, although RDW was higher in the ISR group, no significance was apparent in multivariate analysis.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Preprocedural Laboratory Parameters as Predictors of Drug-Eluting Stent Restenosis in Coronary Chronic Total Occlusion Lesions

Shen

et al. 2018

Angiology

View full text Add to dashboard Cite

This retrospective, single-center study assessed the prognostic value of several emerging inflammatory markers as predictors of in-stent restenosis (ISR) after drug-eluting stent implantation for coronary chronic total occlusion (CTO) lesions. Consecutive patients (n = 416) who underwent successful percutaneous coronary intervention (PCI) for documented CTO lesions and with follow-up angiography were enrolled. Preprocedural high-sensitivity C-reactive protein (hsCRP), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and red cell distribution width (RDW) were analyzed. At mean follow-up of 14.4 ± 3.3 months, ISR occurred in 72 patients. Compared with the non-ISR group, preprocedural hsCRP level, PLR, NLR, and RDW were significantly higher in the ISR group. The ISR group also had significantly greater proportions of patients with diabetes and smoking history, lower estimated glomerular filtration rate, higher low-density lipoprotein cholesterol (LDL-C) level and neutrophil count, longer stent length, and higher rate of severe dissection. In multivariate analysis, NLR (odds ratio [OR]: 3.110; 95% confidence interval [CI], 2.102-4.063; P < .001) and PLR (OR: 1.029; 95% CI, 1.016-1.143; P < .001) were independent predictors of ISR, along with LDL-C level and stent length. In conclusion, higher preprocedural NLR and PLR levels were independent risk factors for the development of ISR in patients who underwent PCI for CTO lesions.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of Preprocedural Laboratory Parameters as Predictors of Drug-Eluting Stent Restenosis in Coronary Chronic Total Occlusion Lesions

Shen

et al. 2018

Angiology

View full text Add to dashboard Cite

show abstract

“…One of the most important limitations affecting the long-term outcomes of CAD invasive treatment is restenosis [ 70 ] which occurs more frequently in patients with elevated RDW values, which is the case following both bare-metal [ 61 ] and antimitotic drug-eluting stent implantation [ 64 ]. RDW is also valuable in assessing the risk of major bleeding complications in patients undergoing PCI [ 60 ], as well as the risk of contrast-induced nephropathy [ 65 ].…”

Section: The Prognostic and Diagnostic Value Of Rdw In Cadmentioning

confidence: 99%

The Prognostic Role of Red Blood Cell Distribution Width in Coronary Artery Disease: A Review of the Pathophysiology

et al. 2015

View full text Add to dashboard Cite

Red blood cell distribution width (RDW) is a measure of red blood cell volume variations (anisocytosis) and is reported as part of a standard complete blood count. In recent years, numerous studies have noted the importance of RDW as a predictor of poor clinical outcomes in the settings of various diseases, including coronary artery disease (CAD). In this paper, we discuss the prognostic value of RDW in CAD and describe the pathophysiological connection between RDW and acute coronary syndrome. In our opinion, the negative prognostic effects of elevated RDW levels may be attributed to the adverse effects of independent risk factors such as inflammation, oxidative stress, and vitamin D3 and iron deficiency on bone marrow function (erythropoiesis). Elevated RDW values may reflect the intensity of these phenomena and their unfavorable impacts on bone marrow erythropoiesis. Furthermore, decreased red blood cell deformability among patients with higher RDW values impairs blood flow through the microcirculation, resulting in the diminution of oxygen supply at the tissue level, particularly among patients suffering from myocardial infarction treated with urgent revascularization.

show abstract

“…The underlying mechanism of the relationship between RDW and DES restenosis is still not clearly elucidated. A recent study showed that an increased RDW significantly predicts bare metal stent restenosis and might represent a useful screening tool to stratify patients according to a higher or a lower risk of ISR after stent implantation in patients with stable and unstable angina pectoris [16]. In the present study, we have determined that RDW and CRP levels were higher in the ISR group and both of these biomarkers were independently associated with the presence of DES restenosis.…”

mentioning

confidence: 60%

The association of red blood cell distribution width with drug-eluting stent restenosis in unstable angina pectoris patients

Zhao

Jin

et al. 2015

International Journal of Cardiology

View full text Add to dashboard Cite

Preprocedural red blood cell distribution width predicts bare metal stent restenosis

Abstract: Increased preinterventional RDW significantly predicts bare metal stent restenosis and might represent a useful screening tool to stratify patients according to a higher or a lower risk of ISR after stent implantation in patients with stable and unstable angina pectoris.

Cited by 12 publications

References 32 publications

Evaluation of Preprocedural Laboratory Parameters as Predictors of Drug-Eluting Stent Restenosis in Coronary Chronic Total Occlusion Lesions

Evaluation of Preprocedural Laboratory Parameters as Predictors of Drug-Eluting Stent Restenosis in Coronary Chronic Total Occlusion Lesions

The Prognostic Role of Red Blood Cell Distribution Width in Coronary Artery Disease: A Review of the Pathophysiology

The association of red blood cell distribution width with drug-eluting stent restenosis in unstable angina pectoris patients

Contact Info

Product

Resources

About