Preprocedural N‐Terminal Pro‐Brain Natriuretic Peptide (NT‐proBNP) Is Similar to the Mehran Contrast‐Induced Nephropathy (CIN) Score in Predicting CIN Following Elective Coronary Angiography

Liu, Yong; He, Y; Tan, Ning; Chen, Ji‐yan-Y.; Liu, Yuan‐hui-H.; Yang, Da‐hao-H.; Huang, Shui‐Jin-J.; Ye, Piao; Li, Hua‐long-L.; Ran, Pixin; Duan, Chong‐yang-Y.; Chen, Shi‐qun-Q.; Zhou, Ying‐ling-L.; Chen, Ping‐Yan-Y.

doi:10.1161/jaha.114.001410

Cited by 15 publications

(15 citation statements)

References 59 publications

(65 reference statements)

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“…NT-proBNP is a cardiac and renal neurohumoral signal, which is secreted by ventricular myocytes and excreted by the kidneys. 36 , 37 Myocardial cells in patients with ACS are severely ischemic and hypoxic, and some myocardial cells are necrotic, which stimulates ventricular myocytes to secrete NT-proBNP. 38 High oxidative stress and inflammation and an immune response stimulate release of NT-proBNP, causing its level to significantly increase.…”

Section: Discussionmentioning

confidence: 99%

Risk factors of contrast-induced nephropathy after percutaneous coronary intervention: a retrospective analysis

et al. 2021

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Objective Contrast-induced nephropathy (CIN) is a serious complication in patients with acute coronary syndrome (ACS) and percutaneous coronary intervention (PCI). This study aimed to analyze the potential risk factors for CIN in patients undergoing PCI. Methods Patients with ACS who underwent PCI treatment from January 2017 to January 2020 were selected. The patients’ characteristics and medical information were collected and compared. Results A total of 1331 patients undergoing PCI were included. The incidence of CIN was 15.33%. Logistic regression analyses showed that a left ventricular ejection fraction ≤45% (odds ratio [OR] 4.18, 95% confidence interval [CI] 1.10–7.36), serum creatinine levels ≤60 μmol/L (OR 3.03, 95% CI 1.21–5.57), age ≥65 years (OR 2.75, 95% CI 1.32–4.60), log N-terminal pro-B-type natriuretic peptide levels ≥2.5 pg/mL (OR 2.31, 95% CI 1.18–5.13), uric acid levels ≥350 μmol/L (OR 2.29, 95% CI 1.04–5.30), emergency percutaneous intervention (OR 1.35, 95% CI 0.34–3.12), and triglyceride levels ≤1.30 mmol/L (OR 1.10, 95% CI 0.01–2.27) were independent risk factors for CIN in patients who underwent PCI. Conclusions Early prevention is required to reduce the occurrence of CIN in patients who undergo PCI and have risk factors for CIN.

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Section: Discussionmentioning

confidence: 99%

Risk factors of contrast-induced nephropathy after percutaneous coronary intervention: a retrospective analysis

et al. 2021

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“…However, a total of 101(23.17%) patients with LVEF <40% were included, and patients with NYHA class ≥III were excluded in the analysis. Two more studies conducted by our group also indicated the best cutoff value of NT-proBNP for CI-AKI [ 13 , 20 ] ; however, the number of patients with HFmrEF was limited in these studies. Therefore, the present results are the useful supplements to this work.…”

Section: Discussionmentioning

confidence: 99%

Association of N-terminal pro-brain natriuretic peptide with contrast-induced acute kidney injury and long-term mortality in patients with heart failure and mid-range ejection fraction

Wang

Chen

et al. 2017

Medicine

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The potential value of N-terminal pro-brain natriuretic peptide (NT-proBNP) for contrast-induced acute kidney injury (CI-AKI) in patients with heart failure and mid-range ejection fraction (HFmrEF) is unclear. We investigated whether NT-proBNP is associated with CI-AKI and long-term mortality following elective cardiac catheterization in patients with HFmrEF.A total of 174 consecutive patients with HFmrEF undergoing elective coronary angiography or intervention were enrolled. The primary endpoint was the development of CI-AKI, defined as an absolute increase of ≥0.3 mg/dL or ≥ 50% from baseline serum creatinine with 48 hours after contrast medium exposure. Receiver-operating characteristic curve analysis was conducted, and Youden index was used to determine the best cutoff NT-proBNP value. Multivariable logistic regression and Cox proportional hazards regression analyses were performed to identify the independent risk factors for CI-AKI and long-term mortality, respectively.The incidence of CI-AKI was 12.1%. Patients with CI-AKI had higher NT-proBNP values than those without (4373[1561.9–7470.5] vs 1303[625.2–2482.3], P = 0.003). Receiver-operating characteristic curve revealed that NT-proBNP was not significantly different from the Mehran risk score in predicting CI-AKI (area under the curve [AUC] = 0.723 vs 0.767, P = 0.516). The best cutoff NT-proBNP value for CI-AKI was 3299 pg/mL, with 70.6% sensitivity and 83.1% specificity. Multivariable analysis demonstrated that NT-proBNP ≥3299 pg/mL is significantly related to CI-AKI (odds ratio = 12.79; 95% confidence interval, 3.18–51.49; P < 0.001). Cox regression analysis showed that NT-proBNP ≥3299 pg/mL is associated with long-term mortality (adjusted hazard ratio = 11.91; 95%CI, 2.16–65.70; P = 0.004) during follow-up.In patients with HFmrEF, NT-proBNP ≥3299 pg/mL is associated with CI-AKI and long-term mortality following elective coronary angiography or intervention.

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“…N-terminal pro-brain natriuretic peptide (NT-proBNP) is a simple but useful biomarker of cardiac and renal function and is associated with short-and long-term outcomes. 7,8) Some recent studies suggest that NT-proBNP could be useful to predict CI-AKI after coronary angiography(CAG) 9) or PCI, including patients with ST-segmentelevation myocardial infarction(STEMI), 10,11) acute coronary syndrome(ACS), 12) chronic kidney disease(CKD), 13) and heart failure(HF). 14) However, the relationship between the pre-procedural NT-proBNP and the risk of CI-AKI in elderly patients undergoing elective PCI has not yet been well examined.…”

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confidence: 99%

Pre-Procedural N-Terminal Pro-B Type Natriuretic Peptide Predicts Contrast-Induced Acute Kidney Injury and Long-Term Outcome in Elderly Patients After Elective Percutaneous Coronary Intervention

Lin

You

et al. 2018

Int. Heart J.

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The aim of the study is to evaluate the association of pre-procedural N-terminal pro-B type natriuretic peptide (NT-proBNP) with contrast-induced acute kidney injury (CI-AKI) and long-term outcomes in elderly patients undergoing elective percutaneous coronary intervention (PCI).A total of 540 patients aged ≥ 75 years who had undergone elective PCI between January 2012 and December 2015 were enrolled in this study. Admission NT-proBNP levels were measured before PCI. CI-AKI was defined as a relative increase in serum creatinine (SCr) of ≥50%, or an absolute increase of ≥ 0.3 mg/dL, occurring within 48 hours after contrast medium exposure. The predictive value of NT-proBNP for predicting CI-AKI was assessed by receiver operating characteristic (ROC) and multivariable logistic regression analysis.A total of 54 (10.0%) patients developed CI-AKI. The best cutoff value of NT-pro-BNP for detecting CI-AKI was 1133 pg/mL with 66.7% sensitivity and 70.8% specificity according to the ROC analysis (C statistic = 0.719; 95% CI, 0.679-0.756). Multivariable analysis demonstrated that Lg-NT-proBNP is significantly related to CI-AKI (odds ratio [OR] = 3.892; 95% CI, 1.996-7.590; P < 0.001). Cox regression analysis showed that Lg-NT-proBNP is associated with long-term mortality (adjusted hazard ratio [HR] = 2.158; 95% CI, 1.246-3.740; P = 0.006) during follow-up.Pre-procedural NT-proBNP is a significant and independent predictor of CI-AKI and long-term mortality in elderly patients following elective PCI, and the best cutoff point for predicting CI-AKI was 1133 pg/mL.

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Preprocedural N‐Terminal Pro‐Brain Natriuretic Peptide (NT‐proBNP) Is Similar to the Mehran Contrast‐Induced Nephropathy (CIN) Score in Predicting CIN Following Elective Coronary Angiography

Cited by 15 publications

References 59 publications

Risk factors of contrast-induced nephropathy after percutaneous coronary intervention: a retrospective analysis

Risk factors of contrast-induced nephropathy after percutaneous coronary intervention: a retrospective analysis

Association of N-terminal pro-brain natriuretic peptide with contrast-induced acute kidney injury and long-term mortality in patients with heart failure and mid-range ejection fraction

Pre-Procedural N-Terminal Pro-B Type Natriuretic Peptide Predicts Contrast-Induced Acute Kidney Injury and Long-Term Outcome in Elderly Patients After Elective Percutaneous Coronary Intervention

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