Prepregnancy Obesity and Fetal Death: A Study Within the Danish National Birth Cohort

Nøhr, Ellen Aagaard; Bech, Bodil Hammer; Davies, Michael J.; Frydenberg, Morten; Henriksen, Tine Brink; Olsen, Jørn

doi:10.1097/01.ogx.0000193840.39718.cf

Cited by 117 publications

(165 citation statements)

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“…19 The finding that obese women are at the higher risk of preeclampsia and GDM is similar to the studies which showed obesity is a risk factor for preeclampsia and GDM, but the mechanism involved are not known. [20][21][22][23][24][25] Women with the low BMI are relatively protected against preeclampsia, which is also confirmed in present study. 26 In the current study the dietary intake of vitamin D was almost same in all the three groups.…”

Section: Discussionsupporting

confidence: 78%

Hypovitaminosis D in pregnancy and its correlation with preeclampsia and gestational diabetes mellitus

Kumari

Mitra

Tiwari

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: Hypovitaminosis D has been associated with a number of adverse pregnancy outcomes, and has been recognised as a public health concern. The objective of this study was to determine the impact of Vitamin D deficiency on maternal complications like gestational diabetes mellitus (GDM) and preeclampsia (PE) among pregnant women.Methods: This was a case control study undertaken at antenatal clinics and indoor of BRD Medical College, Gorakhpur, Uttar Pradesh, India. Two maternal blood samples, one at <20 weeks and other at term along with cord blood at delivery were taken. Patients were classified into preeclampsia (n=60), gestational diabetes mellitus (n=35) and control group (n=180) after abstracting past medical records at delivery. Vitamin D was estimated by 25- Hydroxyvitamin D125 RIA kit and categorized according to ACOG criteria. Statistical analysis was done by using chi square test, binary logistic regression and Pearson’s correlation coefficient to compare between two variables. P<0.05 was considered statistically significant.Results: Out of 275 women included in the study, 78% of women were Vitamin D deficient. Mean serum vitamin D was significantly lower among preeclamptic women 11.53±6.22 ng/ml and GDM women 12.62±6.69 ng/ml as compared to controls 24.25±14.44 ng/ml (median=18.2 ng/ml) (P<0.05). Vitamin D deficiency was significantly higher in pregnant women GDM (94.28% vs 68.3%) and preeclampsia (96.67% vs 68.3%) when compared to uncomplicated group.Conclusions: Maternal vitamin D deficiency is highly prevalent in early pregnancy and is significantly associated with elevated risk for GDM and preeclampsia.

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Section: Discussionsupporting

confidence: 78%

Hypovitaminosis D in pregnancy and its correlation with preeclampsia and gestational diabetes mellitus

Kumari

Mitra

Tiwari

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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“…Our data shows for the first time that maternal obesity is associated with placental oxidative stress in the first trimester. This finding supports a first trimester origin for the observed increased rate of placental dysfunction noted in obese women later in pregnancy, although a direct relationship cannot be established from this investigation [10][11][12][13][14][15]. Oxidative stress is increasingly viewed as an upstream process resulting in inflammation and cellular injury.…”

Section: Discussionsupporting

confidence: 59%

“…However, the relationship between maternal obesity and placental oxidative stress is unclear. Maternal obesity is associated with placental dysfunction, characterized clinically by preeclampsia, second trimester spontaneous abortion, and stillbirth, in a dose-dependent fashion with body mass index (BMI) [10][11][12][13][14][15]. More than 1 in 3 women in the United States are obese at the time of conception, defined as a BMI equal to or greater than 30 kg/m 2 [16].…”

Section: Introductionmentioning

confidence: 99%

Maternal Obesity and Placental Oxidative Stress in the First Trimester

Alanis¹,

Steadman²,

Manevich³

et al. 2012

J Obes Weight Loss Ther

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“…Recent evidence showed inadequate weight gain during pregnancy (both low and excessive) was linked to preterm birth at various BMI starting points. 12,13 Women who do not gain weight within the guidelines set by the Institute of Medicine (IOM) 14 are more likely to have suboptimal outcomes than women who gain the recommended amount of weight for their BMI. 15 We investigated maternal weight in relation to core symptoms of ADHD in offspring using prospective data gathered within three Nordic pregnancy cohorts considering also the combination of pre-pregnancy BMI and pregnancy weight gain.…”

Section: Introductionmentioning

confidence: 99%

Maternal adiposity prior to pregnancy is associated with ADHD symptoms in offspring: evidence from three prospective pregnancy cohorts

et al. 2007

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Objectives: We examine whether pregnancy weight (pre-pregnancy body mass index (BMI) and/or weight gain) is related to core symptoms of attention deficit hyperactivity disorder (ADHD) in school-age offspring. Design: Follow-up of prospective pregnancy cohorts from Sweden, Denmark and Finland within the Nordic Network on ADHD. Methods: Maternal pregnancy and delivery data were collected prospectively. Teachers rated inattention and hyperactivity symptoms in offspring. High scores were defined as at least one core symptom rated as 'severe' and two as 'present' (approximately 10% of children scored in this range). Logistic regression and latent class analyses were used to examine maternal pregnancy weight in relation to children's ADHD core symptoms. Results: Teacher rated 12 556 school-aged children. Gestational weight gain outside of the Institute of Medicine guidelines was not related to ADHD symptoms (below recommendations: odds ratio (OR): 0.96; 95% confidence interval (CI): 0.81, 1.14; above recommendations: OR: 0.98; 95% CI: 0.82, 1.16). To examine various patterns of pre-pregnancy BMI and weight gain, we used latent class analysis and found significant associations between classes that included pre-pregnancy overweight or obesity and a high ADHD symptom score in offspring, ORs ranged between 1.37 (95% CI: 1.07, 1.75) and 1.89 (95% CI: 1.13, 3.15) adjusted for gestational age, birth weight, weight gain, pregnancy smoking, maternal age, maternal education, child gender, family structure and cohort country of origin. Children of women who were both overweight and gained a large amount of weight during gestation had a 2-fold risk of ADHD symptoms (OR: 2.10, 95% CI: 1.19, 3.72) compared to normal-weight women. Conclusions: We show for the first time that pre-pregnancy BMI is associated with ADHD symptoms in children. Our results are of public health significance if the associations are causal and will then add ADHD symptoms in offspring to the list of deleterious outcomes related to overweight and obesity in the prenatal period.

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Prepregnancy Obesity and Fetal Death: A Study Within the Danish National Birth Cohort

Cited by 117 publications

References 0 publications

Hypovitaminosis D in pregnancy and its correlation with preeclampsia and gestational diabetes mellitus

Hypovitaminosis D in pregnancy and its correlation with preeclampsia and gestational diabetes mellitus

Maternal Obesity and Placental Oxidative Stress in the First Trimester

Maternal adiposity prior to pregnancy is associated with ADHD symptoms in offspring: evidence from three prospective pregnancy cohorts

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