Preperimetric Glaucoma Prospective Study (PPGPS): Predicting Visual Field Progression With Basal Optic Nerve Head Blood Flow in Normotensive PPG Eyes

Shiga, Yukihiro; Aizawa, Naoko; Tsuda, S.; Yokoyama, Yû; Omodaka, Kazuko; Kunikata, Hiroshi; Yasui, Tomoki; Kato, Keiichi; Kurashima, Hiroaki; Miyamoto, Etsuyo; Hashimoto, Michie; Nakazawa, Toru

doi:10.1167/tvst.7.1.11

Cited by 45 publications

(30 citation statements)

References 19 publications

(26 reference statements)

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“…As discussed above, a negative correlation of MT- or MV-FAI with SBP and DBP is considered to represent the effects of an age-related increase in the stiffness of large arteries on the waveform parameters. Many previous studies have reported a lower MT in NTG eyes 25 , 50 , 51 , and MT-FAI was also reported to be significantly lower in NTG eyes than in normal eyes 25 . Both MT and MT-FAI were reported to be significantly higher in glaucoma suspect/fellow eyes without a functional loss than in normal eyes 26 .…”

Section: Discussionmentioning

confidence: 80%

Characterization of laser speckle flowgraphy pulse waveform parameters for the evaluation of the optic nerve head and retinal circulation

Enomoto

Anraku

Tomita

et al. 2021

Sci Rep

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To characterize laser speckle flowgraphy (LSFG) pulse waveform parameters for ocular circulation evaluation, a multicenter, prospective, cross-sectional study was conducted in 111 eyes of 86 healthy Japanese individuals. Optic nerve head (ONH) tissue-area, vessel-area mean blur rate (MT and MV, respectively), and MT and MV pulse waveform parameters were obtained using LSFG and ONH structural parameters using planimetry. Multivariate linear mixed-effects modeled regression analysis identified factors contributing to MT- or MV-waveforms using age, gender, smoking history, body mass index, systolic and diastolic blood pressure, heart rate, intraocular pressure, axial length, disc, rim, and β-peripapillary atrophy areas, MT or MV, central retinal artery, and vein equivalents (CRAE and CRVE) as explanatory variables. MT- and MV-waveforms significantly correlated with one or more systemic factors, consistent with previous studies. Following confounding factor adjustment, MT-Skew significantly negatively correlated with β-PPA area (P = 0.026); MT- and MV-flow acceleration index positively correlated with CRAE, MT, and MV (P = 0.041–< 0.001), compatible with these parameters’ observed correlations to systemic factors. Significantly negative correlations of the blowout score and acceleration time index to CRAE partly conflicted with their correlations to systemic factors, and other waveform parameters showed little correlation to ocular factors. Thus, Skew and flow acceleration index assisted the in vivo ocular circulation characterization.

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Section: Discussionmentioning

confidence: 80%

Characterization of laser speckle flowgraphy pulse waveform parameters for the evaluation of the optic nerve head and retinal circulation

Enomoto

Anraku

Tomita

et al. 2021

Sci Rep

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“…Thus, IOPindependent risk factors, such as vascular impairment, must be identified. [2][3][4][5][6] However, as local blood flow (BF) can also be reduced secondary to neurodegeneration, 7 it is difficult to determine the cause and effect relationship between these factors. Nevertheless, there have been various etiologic studies on the influence of blood pressure (BP) and ocular perfusion pressure (OPP) on the prevalence, incidence, and progression of glaucoma.…”

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confidence: 99%

Sectoral Differences in the Association of Optic Nerve Head Blood Flow and Glaucomatous Visual Field Defect Severity and Progression

Kiyota

Shiga

Yasuda

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To investigate sectoral differences in the relationship between optic nerve head tissue blood flow, anatomically corresponding visual field defect severity, and future progression. METHODS. This retrospective longitudinal medical chart review comprised 508 eyes of 319 open-angle glaucoma patients (mean deviation: À9.2 6 7.0 dB), followed for an average of 4.7 6 1.1 years; an average 11.7 6 3.7 visual field tests were performed. Average total deviation (TD) was calculated in the superior, central, and inferior sectors of the Humphrey 24-2 program. The optic nerve head was divided to obtain inferior, temporal, and superior tissue-area mean blur rate (MT), derived from laser speckle flowgraphy. At baseline, the correlation between MT and TD was compared in anatomically corresponding sectors. We performed a multivariate analysis to determine the contribution of baseline MT to corresponding TD slope and to determine background factors influencing superior to temporal MT. We used a linear-mixed effect model for the statistical analysis. RESULTS. At baseline, the highest b coefficients were found between MT-superior and TDinferior, MT-temporal and TD-central, and between MT-inferior and TD-superior, in that order (b ¼ 0.38, b ¼ 0.27, b ¼ 0.26, respectively). MT-superior and MT-temporal independently contributed to corresponding TD slope (P < 0.05). Male sex, high body mass index, and the prevalence of sleep apnea syndrome were contributing factors to lower superior to temporal MT (P < 0.05). CONCLUSIONS. Review of medical history, measurements of systemic variables, and laser speckle flowgraphy parameters might help clinicians to predict visual field defect severity and progression. Keywords: retinal blood flow, glaucoma, visual field the ONH near the lamina cribrosa and has been found to be usable for interindividual comparisons. 21,28,29 In addition to these advantages, the LSFG software provides pulse waveform

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“…[ 31 ] In patients with preperimetric glaucoma (PPG), we found that tissue blood flow had already decreased, [ 32 ] and that reduced basal tissue blood flow in the ONH was associated with visual field progression. [ 33 ] Taken together, these results show that reductions in blood flow to the ONH tissue (which is fed by a branch of the short posterior ciliary artery and the circle of Zinn-Haller), might be related to changes in the laminar pores. We originally used OCTA-derived data for segmenting the 3D pore structure.…”

Section: Discussionmentioning

confidence: 79%

Pilot study for three-dimensional assessment of laminar pore structure in patients with glaucoma, as measured with swept source optical coherence tomography

Omodaka

Maekawa

et al. 2018

PLoS ONE

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PurposeTo develop a method to quantify, based on swept-source optical coherence tomography (OCT), the 3D structure of the laminar pores in patients with glaucoma.MethodsThis retrospective study examined 160 laminar pores from 8 eyes of 8 cases: 4 normal subjects and 4 open-angle glaucoma (OAG) patients. We reconstructed 3D volume data for a 3 x 3 mm disc, using a method similar to OCT angiography, and segmented the structure of the lamina cribrosa. Then, we manually segmented each laminar pore in sequential C-scan images (>90 slices at 2.6-micron intervals) with VCAT5 (RIKEN, Japan). We compared the control and OAG subjects with the Mann-Whitney U test. Differences were considered significant at p < 0.05.ResultsWe found that the laminar pores of the OAG patients had a significantly smaller average cross-sectional area, smaller 3D volume (adjusted to the average thickness of the lamina cribrosa), and higher true sphericity, and lower principal value (P1, 2, 3) of the 3D structure data (all: p < 0.0001). The topographic distribution of damaged laminar pores was consistent with the damaged area of the macular map.ConclusionWe successfully developed a method to quantify the 3D structure of the laminar pores; providing a useful tool to assess lamina cribrosa-associated risk factors for glaucoma. These findings promise to benefit future investigations into the pathomechanisms of glaucoma.

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Preperimetric Glaucoma Prospective Study (PPGPS): Predicting Visual Field Progression With Basal Optic Nerve Head Blood Flow in Normotensive PPG Eyes

Cited by 45 publications

References 19 publications

Characterization of laser speckle flowgraphy pulse waveform parameters for the evaluation of the optic nerve head and retinal circulation

Characterization of laser speckle flowgraphy pulse waveform parameters for the evaluation of the optic nerve head and retinal circulation

Sectoral Differences in the Association of Optic Nerve Head Blood Flow and Glaucomatous Visual Field Defect Severity and Progression

Pilot study for three-dimensional assessment of laminar pore structure in patients with glaucoma, as measured with swept source optical coherence tomography

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