Prepeak of trolox caused by theophylline and its application to the determination of theophylline in rat plasma

Development of a novel and simple method for clinical therapeutic drug monitoring of aminophylline in humans based on a MWNTs-SiO2/Au composite modified screen-printed electrode

“…3 Hospital. According to the literature, 36,37 clinical blood samples were collected from the asthma patient volunteers aer signing informed consent. The male volunteer was 82 kg and then administered slow intravenous drip at the dose of 0.25 g aminophylline.…”

A theophylline quartz crystal microbalance biosensor based on recognition of RNA aptamer and amplification of signal

“…23 Furthermore, it should be also noted that the limit of detection achieved with our designed biosensor is lower than those obtained with non-aptamer modied surface plasmon resonance sensors via electropolymerized molecularly imprinted polythiophenes (limit of detection, 3.36 mM) 38 and an electrochemical detection coupled with high-performance liquid chromatography (limit of detection, 0.55 mM). 25 The size effect of Au NPs on the sensitivity and linear range of the biosensor for theophylline detection was also investigated. When the prepared Au NPs with average sizes of 8, 13 and 30 nm were used for binding with RNA2, the sensitivities of the biosensor were determined to be 68.1, 107.8 and 186.3 Hz mM À1 , and the linear ranges of the present biosensor were determined to be 0.08-3.0, 0.02-1.8 and 0.02-0.8 mM, respectively.…”

Enteric Theophylline Delivery by a New Type of Polymer‐Grafted Magnetic Nanoparticles

“…Theophylline is used for the treatment of chronic bronchitis and asthma. Although the serum therapeutic range of theophyline is quite high (5–20 mg L −1 ), the more consumption of this compound causes heartburn tachycardia, anorexia, and insomnia . Theophylline can be metabolized in the liver and converted to unwanted compounds and so interacted with other commonly drugs.…”