Development of a novel and simple method for clinical therapeutic drug monitoring of aminophylline in humans based on a MWNTs-SiO<sub>2</sub>/Au composite modified screen-printed electrode

Peng, Anlin; Wang, Yuting; Xiao, Jing; Wang, Shi; Ding, Hong

doi:10.1039/c5ay02700d

Cited by 7 publications

(3 citation statements)

References 44 publications

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“…Electrochemical approaches for other clinically relevant drugs analysis have been also widely explored, including cefixime, benzimidazole, aminophylline, celecoxib, ganciclovir, meloxicam, cyclosporine A, and so on. , For example, a MIP-based sensor for cefixime (CEF) was fabricated by modifying Fe@Au NPs involved in 2-aminoethanethiol (2-AET) functionalized MWCNT with cross-linked polymeric matrices on the glassy carbon electrode (GCE) . CEF imprinted polymer film was fabricated in PBS (pH 6.0) using electrochemical catalytic reaction of pyrrole and CEF.…”

Section: The Detection Of Small Moleculesmentioning

confidence: 99%

“…A variety of electrocatalytic electrode coating materials have been broadly developed to construct biosensors for drugs detection in blood samples, including MWNTs composite, , poly-3-amino-1,2,4-triazole-5-thiol, graphene nanocomposites, ,,, and Au nanoparticle/polyamidoamine dendrimer . In addition, MIP-modified materials was also reported for drugs detection in blood samples, including nanoporous gold leaf for warfarin sodium analysis and MIP-coated magnetite nanoparticles for venlafaxine determination …”

Section: The Detection Of Small Moleculesmentioning

confidence: 99%

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Electrochemical Biosensors for Whole Blood Analysis: Recent Progress, Challenges, and Future Perspectives

Zhang

Zhu

et al. 2023

Chem. Rev.

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Whole blood, as one of the most significant biological fluids, provides critical information for health management and disease monitoring. Over the past 10 years, advances in nanotechnology, microfluidics, and biomarker research have spurred the development of powerful miniaturized diagnostic systems for whole blood testing toward the goal of disease monitoring and treatment. Among the techniques employed for whole-blood diagnostics, electrochemical biosensors, as known to be rapid, sensitive, capable of miniaturization, reagentless and washing free, become a class of emerging technology to achieve the target detection specifically and directly in complex media, e.g., whole blood or even in the living body. Here we are aiming to provide a comprehensive review to summarize advances over the past decade in the development of electrochemical sensors for whole blood analysis. Further, we address the remaining challenges and opportunities to integrate electrochemical sensing platforms.

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Section: The Detection Of Small Moleculesmentioning

confidence: 99%

Section: The Detection Of Small Moleculesmentioning

confidence: 99%

Electrochemical Biosensors for Whole Blood Analysis: Recent Progress, Challenges, and Future Perspectives

Zhang

Zhu

et al. 2023

Chem. Rev.

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“…AMP is also used as an ingredient of skin cream products but can allergic reactions due to the ethylenediamine component (Wang & Wang, 2006). AMP quickly releases theophylline in buffer solutions (pH 7.4) and blood samples, and when the dose is greater than 20 µg/mL, it can occasionally produce serious toxicity issues, including nausea, emesis, and central nervous system excitation (Kesavan & John, 2014;Peng, Wang, Xiao, Wang, & Ding, 2016). In order to avoid this situation, it is essential to develop an easy and sensitive analytical method capable of detecting this drug.…”

Section: Introductionmentioning

confidence: 99%

Detection of aminophylline in serum using an immunochromatographic strip test

Suryoprabowo

Kuang

et al. 2019

Food and Agricultural Immunology

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Aminophylline (AMP), a bronchodilator drug, is a modified form of theophylline (the pharmacological active ingredient). AMP is often given to treat respiratory diseases, including bronchial asthma, blocked emphysema, panting bronchitis, and cardiogenic asthma. In this study, we developed a rapid and sensitive method to determine AMP concentration in mouse serum. A sensitive monoclonal antibody against AMP was produced by immunizing BALB/c mice with a well-characterized AMP2-keyhole limpet hemocyanin and coating antigen (hapten-AMP1-OVA). The coating antigen and goat anti-mouse IgG antibody were sprayed onto a nitrocellulose membrane representing the test and control lines, respectively. Under optimized conditions, the cut-off limits of the test strip were 50 ng/mL in 0.01 M phosphate buffered saline (pH 7.4) and 250 ng/mL in serum. The results were obtained within 10 min and revealed that this immunochromatographic strip test is a sensitive, rapid, and simple tool for the detection of AMP in serum.

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Fast and Simple Electrochemical Analysis Kit for Quality Control of Narrow Therapeutic Index Drugs

Guedes

Santos

2018

Electroanalysis

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The use of multiple‐pulse amperometry (MPA) for the determination of narrow therapeutic index (NTI) drugs using batch injection analysis (BIA) with carbon screen‐printed electrodes (SPE) is proposed, seeking to develop a practical and low‐cost analysis kit for application in routine quality control of these drugs. The electrochemical behaviors of aminophylline, carbamazepine, clindamycin, colchicine, minoxidil, prazosin, procainamide, theophylline, warfarin and verapamil were evaluated in different electrolytes, but just one, the 0.1 mol L−1 phosphate buffer, pH 7.0, was chosen for determination of all the analytes. The amperometric detection was optimized as a function of the best oxidation potential for carbon SPE for each analyte, which was in a range from 0.7 to 1.1 V. The injection conditions were determined as a function of the velocity and the volume injected by the BIA system, which were 92.5 μL s−1 and 100 μL, respectively. Under these conditions, a good repeatability (RSD<3 %), high analytical frequency (>215 determinations per hour), large linear ranges and low LOD (<0.42 μmol L−1) for all the NTI drugs were obtained. Furthermore, the proposed method provided an easy qualitative analysis of the investigated analytes using MPA detection. The addition‐recovery studies in pharmaceutical samples containing NTI drugs and the comparison with official methods showed that the proposed analysis Kit is a very fast, simple and efficient alternative for quantification of these analytes.

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Development of a novel and simple method for clinical therapeutic drug monitoring of aminophylline in humans based on a MWNTs-SiO₂/Au composite modified screen-printed electrode

Abstract: Aminophylline is a drug that needs therapeutic drug monitoring in clinical treatment.

Cited by 7 publications

References 44 publications

Electrochemical Biosensors for Whole Blood Analysis: Recent Progress, Challenges, and Future Perspectives

Electrochemical Biosensors for Whole Blood Analysis: Recent Progress, Challenges, and Future Perspectives

Detection of aminophylline in serum using an immunochromatographic strip test

Fast and Simple Electrochemical Analysis Kit for Quality Control of Narrow Therapeutic Index Drugs

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Development of a novel and simple method for clinical therapeutic drug monitoring of aminophylline in humans based on a MWNTs-SiO2/Au composite modified screen-printed electrode

Abstract: Aminophylline is a drug that needs therapeutic drug monitoring in clinical treatment.

Cited by 7 publications

References 44 publications

Electrochemical Biosensors for Whole Blood Analysis: Recent Progress, Challenges, and Future Perspectives

Electrochemical Biosensors for Whole Blood Analysis: Recent Progress, Challenges, and Future Perspectives

Detection of aminophylline in serum using an immunochromatographic strip test

Fast and Simple Electrochemical Analysis Kit for Quality Control of Narrow Therapeutic Index Drugs

Contact Info

Product

Resources

About

Development of a novel and simple method for clinical therapeutic drug monitoring of aminophylline in humans based on a MWNTs-SiO₂/Au composite modified screen-printed electrode