Prepartal overfeeding alters the lipidomic profiles in the liver and the adipose tissue of transition dairy cows

Qin, Nanbing; Kokkonen, Tuomo; Salin, Siru; Seppänen‐Laakso, Tuulikki; Taponen, Juhani; Vanhatalo, Aila; Elo, Kari

doi:10.1007/s11306-016-1160-0

Cited by 6 publications

(16 citation statements)

References 54 publications

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“…Previously we reported that the HE group had higher hepatic total lipid concentration compared with the CON group at −8 and 9 d (Qin et al, 2017). At the gene expression level, the increase of total lipid concentration under prepartal high-energy feeding was reflected by the upregulation of LXR/RXR activation pathway in the HE group compared with the CON group at −8 d because LXR/RXR activation is a pathway that promotes lipogenesis by stimulating sterol regulatory element-binding protein 1c (Schultz et al, 2000).…”

Section: Hepatic Lipogenesismentioning

confidence: 78%

“…This study presents the changes in hepatic lipidomic and gene expression profiles during the periparturient period in response to different prepartal energy intake levels. Parts of the results from the same experiment were published in earlier papers, including the whole lipidome analyses in the liver and AT (Qin et al, 2017), the IVGTT results (Salin et al, 2017), and the measurements of animal performance and blood metabolites as well as the qPCR analyses of 7 hepatic genes involved in insulin signaling, inflammatory response, and gluconeogenesis (Selim et al, 2014). Despite the marked difference in energy intake between the 2 feeding groups, we found no diet effect in either BW change (1.3 vs. 1.1 kg/d; HE vs. CON) during the dry period or BCS before calving (3.7 vs. 3.8; HE vs. CON).…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, the application of lipidomics has enabled novel insights into the role of sphingolipids in the physiological adaptation in periparturient cows. Changed sphingolipid concentrations near calving were reported in the plasma, liver, AT, and skeletal muscle of cows (Imhasly et al, 2015;Qin et al, 2017;Rico et al, 2017). Comparisons between cows of different adiposity further suggested the associations between lipid mobilization and the concentrations of Cer, hexosyl ceramide (HexCer), and lactosylceramide in plasma and liver and the association between systemic IR and specific Cer during the periparturient period (Rico et al, 2015(Rico et al, , 2017.…”

Section: Introductionmentioning

confidence: 92%

“…The data processing using freely available MZmine 2 open-source software (http:// mzmine .sourceforge .net/ ) included alignment of peaks, peak integration, normalization, and peak identification based on an internal spectral library. The analytical procedure was modified from that in Nygren et al (2011), as described by Qin et al (2017). The profiling of Cer and HexCer was carried out using the negative-electrospray ionization mode, and the profiling of SM was carried out using the positive-electrospray ionization mode.…”

Section: Lipidomic Profilingmentioning

confidence: 99%

“…Comparisons between cows of different adiposity further suggested the associations between lipid mobilization and the concentrations of Cer, hexosyl ceramide (HexCer), and lactosylceramide in plasma and liver and the association between systemic IR and specific Cer during the periparturient period (Rico et al, 2015(Rico et al, , 2017. Moreover, prepartal high-energy feeding was reported to increase the concentration of specific Cer and the total concentration of sphingomyelin (SM) in AT near calving (Qin et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Prepartal high-energy feeding with grass silage-based diets does not disturb the hepatic adaptation of dairy cows during the periparturient period

Qin

Kokkonen

Salin

et al. 2018

Journal of Dairy Science

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The liver of dairy cow naturally undergoes metabolic adaptation during the periparturient period in response to the increasing demand for nutrients. The hepatic adaptation is affected by prepartal energy intake level and is potentially associated with inflammatory responses. To study the changes in the liver function during the periparturient period, 16 cows (body condition score = 3.7 ± 0.3, mean ± standard deviation; parity = second through fourth) were allocated to a grass silage-based controlled-energy diet (104 MJ/d) or a high-energy diet (135 MJ/d) during the last 6 wk before the predicted parturition. Liver samples were collected by biopsy at 8 d before the predicted parturition (-8 d) and at 1 and 9 d after the actual parturition (1 and 9 d). The lipidomic profile of liver samples collected at -8 and 9 d was analyzed using ultra performance liquid chromatography-mass spectrometry-based lipidomics. Liver samples from all the time points were subjected to microarray analysis and the subsequent pathway analysis with Ingenuity Pathway Analysis software (Ingenuity Systems, Mountain View, CA). Prepartal energy intake level affected hepatic gene expression and lipidomic profiles prepartum, whereas little or no effect was observed postpartum. At -8 d, hepatic lipogenesis was promoted by prepartal high-energy feeding through the activation of X receptor/retinoid X receptor pathway and through increased transcription of thyroid hormone-responsive (THRSP). Hepatic inflammatory and acute phase responses at -8 d were suppressed (z-score = -2.236) by prepartal high-energy feeding through the increase in the mRNA abundance of suppressor of cytokine signaling 3 (SOCS3) and the decrease in the mRNA abundance of interleukin 1 (IL1), nuclear factor kappa B 1 (NFKB1), apolipoprotein A1 (APOA1), serum amyloid A3 (SAA3), haptoglobin (HP), lipopolysaccharide-binding protein (LBP), and inter-α-trypsin inhibitor heavy chain 3 (ITIH3). Moreover, prepartal high-energy feeding elevated hepatic concentrations of C18- (7%), C20- (17%), C21- (26%), C23-sphingomyelins (26%), and total saturated sphingomyelin (21%). In addition, cows in both groups displayed increased lipogenesis at the gene expression level after parturition and alterations in the concentration of various sphingolipids between the first and last samplings. In conclusion, prepartal high-energy feeding promoted lipogenesis and suppressed inflammatory and acute phase responses in the liver before parturition, whereas only minor effects were observed after parturition.

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Section: Hepatic Lipogenesismentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

Section: Lipidomic Profilingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prepartal high-energy feeding with grass silage-based diets does not disturb the hepatic adaptation of dairy cows during the periparturient period

Qin

Kokkonen

Salin

et al. 2018

Journal of Dairy Science

Self Cite

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Lipidomics analysis for halal authentication of Triceps brachii, Longissimus dorsi, and Biceps femoris meats: Profiling the lipid composition

Maritha

Harlina

Musfiroh

et al. 2023

LWT

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Review: Lipid biology in the periparturient dairy cow: contemporary perspectives

McFadden

2020

Animal

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Coordinated changes in energy metabolism develop to support gestation and lactation in the periparturient dairy cow. Maternal physiology involves the partitioning of nutrients (i.e. glucose, amino acids and fatty acids (FA)) for fetal growth and milk synthesis. However, the inability of the dairy cow to successfully adapt to a productive lactation may trigger metabolic stress characterized by uncontrolled adipose tissue lipolysis and reduced insulin sensitivity. A consequence is lipotoxicity and hepatic triglyceride deposition that favors the development of fatty liver disease (FLD) and ketosis. This review describes contemporary perspectives pertaining to FA surfeit and complex lipid metabolism in the transition dairy cow. The role of saturated and unsaturated FA as bioactive signaling molecules capable of modulating insulin secretion and sensitivity is explored. Moreover, the metabolic fate of FA as influenced by mitochondrial function is considered. This includes the influence of inadequate mitochondrial oxidation on acylcarnitine status and the use of FA for lipid mediator synthesis. Lipid mediators, including the sphingolipid ceramide and diacylglycerol, are evaluated considering their established ability to inhibit insulin signaling and glucose transport in non-ruminant diabetics. The mechanisms of FLD in the transition cow are revisited with attention centered on glycerophospholipid phosphatidylcholine and triglyceride secretion. The relationship between oxidative stress and oxylipids within the context of insulin antagonism, hepatic steatosis and inflammation is also reviewed. Lastly, peripartal hormonal involvement or lack thereof of adipokines (i.e. leptin, adiponectin) and hepatokines (i.e. fibroblast growth factor-21) is described. Similarities and differences in ruminant and non-ruminant physiology are routinely showcased. Unraveling the lipidome of the dairy cow has generated breakthroughs in our understanding of periparturient lipid biology. Therapeutic approaches that target FA and complex lipid metabolism holds promise to enhance cow health, well-being and productive lifespan.

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Prepartal overfeeding alters the lipidomic profiles in the liver and the adipose tissue of transition dairy cows

Cited by 6 publications

References 54 publications

Prepartal high-energy feeding with grass silage-based diets does not disturb the hepatic adaptation of dairy cows during the periparturient period

Prepartal high-energy feeding with grass silage-based diets does not disturb the hepatic adaptation of dairy cows during the periparturient period

Lipidomics analysis for halal authentication of Triceps brachii, Longissimus dorsi, and Biceps femoris meats: Profiling the lipid composition

Review: Lipid biology in the periparturient dairy cow: contemporary perspectives

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