Preparing an injectable hydrogel with sodium alginate and Type I collagen to create better MSCs growth microenvironment

Zhou, Jian‐Kang; Zhang, Kun; Ma, Shanshan; Liu, Tengfei; Yao, M.; Li, Jingan; Wang, Xiaofeng; Guan, Fangxia

doi:10.1515/epoly-2019-0011

Cited by 23 publications

(13 citation statements)

References 12 publications

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“…After freeze-drying of SA, SP and SPS hydrogel and breaking by liquid nitrogen, the micro-morphologies and internal structure of its surface and cross section was observed. The cross-sectional graph of SA, SP and SPS exhibits obvious three-dimensional network cross-linking structure and porous morphology (Figure 4a), and this is a typical hydrogel inner structure which contributed to better swelling property and further absorbing more copper ion from the lesion location [25]. Wherein, SA and SP show larger pore diameters and thicker pore walls compared with SPS.…”

Section: Resultsmentioning

confidence: 99%

Preparing Sodium Alginate/Polyethyleneimine Spheres for Potential Application of Killing Tumor Cells by Reducing the Concentration of Copper Ions in the Lesions of Colon Cancer

Cui

et al. 2019

Materials

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Inhibition of residual malignant tumors in patients with colon cancer after operation is one of the difficulties in rehabilitation treatment. At present, using biocompatible materials to remove the copper ion which is the growth dependence of malignant tumors in the lesion site is considered to be the frontier means to solve this problem. In this work, we developed a sodium alginate (SA)/polyethyleneimine (PEI) hydrogel sphere via cross-linking method (SA/SP/SA; SP = SA/PEI) as an oral biomaterial for adsorbing and removing copper ions from colon cancer lesions. The evaluated results showed that the SA/PEI/SA (SPS) hydrogel sphere obtained the largest swelling rate at pH 8.3 which was the acid-base value of colon microenvironment and absorbed more copper ions compared with the SA control. The cell experiment presented that the SPS hydrogel sphere owned better compatibility on normal fibroblasts and promoted higher death of colon cancer cells compared with SA/PEI (SP) and SA control. Our data suggested that the SA/PEI hydrogel sphere had the potentiality as an oral biomaterial for inhibiting colon cancer cells.

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Section: Resultsmentioning

confidence: 99%

Preparing Sodium Alginate/Polyethyleneimine Spheres for Potential Application of Killing Tumor Cells by Reducing the Concentration of Copper Ions in the Lesions of Colon Cancer

Cui

et al. 2019

Materials

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“…The preparation procedure of the SA hydrogels was the same as described in detail in the previous work. , In that study, benlysta was introduced into a SA hydrogel solution with a concentration of 320 mg/L before adding Ca 2+ to trigger gelation. The gelation-forming process and the physical map of the benlysta-loaded SA hydrogels before and after the gelation were photographed using a HUAWEI MATE 10PRO mobile phone camera .…”

Section: Methodsmentioning

confidence: 99%

Benlysta-Loaded Sodium Alginate Hydrogel and Its Selective Functions in Promoting Skin Cell Growth and Inhibiting Inflammation

et al. 2020

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Benlysta is a new drug approved by the US Food and Drug Administration (US FDA) in 2019 for the treatment of systemic lupus erythematosus. In this study, we loaded the benlysta in the traditional sodium alginate (SA) hydrogel to investigate the potential application of the drug-loaded hydrogel for skin dressing or hypodermic drug. Live/dead staining images and the CCK-8 results showed that the benlysta-loaded hydrogel could promote the growth of human epidermal cells (HaCat), fibroblasts (L929), and endothelial cells while inhibiting the aggregation of inflammatory cells (macrophages). In addition, the hydrogel degradation and drug release are slow and controllable, and the gel time of drug-loaded hydrogel can be adjusted by adding sodium alginate ratios according to the requirement. In summary, we prepared a time-dependent drug-loaded hydrogel for potential application in the treatment of skin injury that may be caused by other diseases.

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“…Sodium alginate (SA) is a degradable, nontoxic, functional, and compatible biopolymer with a wide range of applications [31,62]. Recently, several authors have combined SA with TiO 2 nanoparticles aimed to enhance the technological and functional properties of alginate-based materials (Table 2).…”

Section: Sodium Alginate-tio 2 Hybrid Materialsmentioning

confidence: 99%

Use of Titanium Dioxide (TiO2) Nanoparticles as Reinforcement Agent of Polysaccharide-Based Materials

et al. 2020

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In recent years, a strong interest has emerged in polysaccharide-hybrid composites and their potential applications, which have interesting functional and technological properties. This review summarizes and discusses the reported advantages and limitations of the functionalization of conventional and nonconventional polysaccharides by adding TiO2 nanoparticles as a reinforcement agent. Their effects on the mechanical, thermal, and UV-barrier properties as well as their water-resistance are discussed. In general, the polysaccharide–TiO2 hybrid materials showed improved physicochemical properties in a TiO2 content-dependent response. It showed antimicrobial activity against bacteria (gram-negative and gram-positive), yeasts, and molds with enhanced UV-protective effects for food and non-food packaging purposes. The reported applications of functionalized polysaccharide–TiO2 composites include photocatalysts (dye removal from aqueous media and water purification), biomedical (wound-healing material, drug delivery systems, biosensor, and tissue engineering), food preservation (fruits and meat), cosmetics (sunscreen and bleaching tooth treatment), textile (cotton fabric self-cleaning), and dye-sensitized solar cells. Furthermore, the polysaccharide–TiO2 showed high biocompatibility without adverse effects on different cell lines, indicating that their use in food, pharmaceutical, and biomedical applications is safe. However, it is necessary to evaluate the structural changes promoted by the storage conditions (time and temperature) on the physicochemical properties of polysaccharide–TiO2 hybrid composites to guarantee their stability during a determined time.

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Preparing an injectable hydrogel with sodium alginate and Type I collagen to create better MSCs growth microenvironment

Cited by 23 publications

References 12 publications

Preparing Sodium Alginate/Polyethyleneimine Spheres for Potential Application of Killing Tumor Cells by Reducing the Concentration of Copper Ions in the Lesions of Colon Cancer

Preparing Sodium Alginate/Polyethyleneimine Spheres for Potential Application of Killing Tumor Cells by Reducing the Concentration of Copper Ions in the Lesions of Colon Cancer

Benlysta-Loaded Sodium Alginate Hydrogel and Its Selective Functions in Promoting Skin Cell Growth and Inhibiting Inflammation

Use of Titanium Dioxide (TiO2) Nanoparticles as Reinforcement Agent of Polysaccharide-Based Materials

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