Benlysta-Loaded Sodium Alginate Hydrogel and Its Selective Functions in Promoting Skin Cell Growth and Inhibiting Inflammation

Wang, Xu‐Jia; Guan, Shuaimeng; Zhang, Kun; Li, Jingan

doi:10.1021/acsomega.0c00283

Cited by 16 publications

(15 citation statements)

References 37 publications

(51 reference statements)

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“…Considering the importance of hydrogels’ swelling in achieving a good system for drug delivery to the wound site and the fact that the exudation of inflammatory fluid and tissue fluid slows down the healing process, a dressing with a high swelling capacity leads to the absorption of excess secretions and rapid wound healing 58 . Therefore, we evaluated the swelling behavior of Alg-Fib@Nis-EDTA at 25, 37, and 42 °C (Fig.…”

Section: Resultsmentioning

confidence: 99%

Designing a new alginate-fibrinogen biomaterial composite hydrogel for wound healing

Soleimanpour

Mirhaji

Jafari

et al. 2022

Sci Rep

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Wound healing is a complex process and rapid healing necessitates a proper micro-environment. Therefore, design and fabrication of an efficacious wound dressing is an impressive innovation in the field of wound healing. The fabricated wound dressing in this scenario was designed using a combination of the appropriate coagulating and anti-bacterial materials like fibrinogen (as coagulating agent), nisin (as anti-bacterial agent), ethylenediaminetetraacetic acid (as anti-bacterial agent), and alginate (as wound healing agent). Biophysical characterization showed that the interaction of fibrinogen and alginate was associated with minor changes in the secondary structure of the protein. Conformational studies showed that the protein was structurally stable at 42 °C, is the maximum temperature of the infected wound. The properties of the hydrogel such as swelling, mechanical resistance, nisin release, antibacterial activity, cytotoxicity, gel porosity, and blood coagulation were assessed. The results showed a slow release for the nisin during 48 h. Antibacterial studies showed an inhibitory effect on the growth of Gram-negative and Gram-positive bacteria. The hydrogel was also capable to absorb a considerable amount of water and provide oxygenation as well as incorporation of the drug into its structure due to its sufficient porosity. Scanning electron microscopy showed pore sizes of about 14–198 µm in the hydrogel. Cell viability studies indicated high biocompatibility of the hydrogel. Blood coagulation test also confirmed the effectiveness of the synthesized hydrogel in accelerating the process of blood clot formation. In vivo studies showed higher rates of wound healing, re-epithelialization, and collagen deposition. According to the findings from in vitro as well as in vivo studies, the designed hydrogel can be considered as a novel attractive wound dressing after further prerequisite assessments.

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Section: Resultsmentioning

confidence: 99%

Designing a new alginate-fibrinogen biomaterial composite hydrogel for wound healing

Soleimanpour

Mirhaji

Jafari

et al. 2022

Sci Rep

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“…Sodium alginate (SA) is a linear anionic polysaccharide polymer [ 75 ]. Because SA contains a large amount of -COO − , SA has obvious pH sensitivity and can quickly form a gel under extremely mild conditions, which can avoid the inactivation of active substances such as sensitive drugs, proteins, cells, and enzymes.…”

Section: Biomaterials For Preparing Hydrogelsmentioning

confidence: 99%

“…Because SA contains a large amount of -COO − , SA has obvious pH sensitivity and can quickly form a gel under extremely mild conditions, which can avoid the inactivation of active substances such as sensitive drugs, proteins, cells, and enzymes. Many wound care products take advantage of the structural similarity between alginate and ECM [ 20 , 75 , 76 ]. Chen et al obtained the OSA-DA-PAM hydrogels through the cross-linking of hydrogen bond and dynamic Schiff’s base reaction between dopamine grafting oxidized SA (OSA-DA) and polyacrylamide (PAM) chains.…”

Section: Biomaterials For Preparing Hydrogelsmentioning

confidence: 99%

Hydrogel Preparation Methods and Biomaterials for Wound Dressing

Liang

et al. 2021

Life

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129

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Wounds have become one of the causes of death worldwide. The metabolic disorder of the wound microenvironment can lead to a series of serious symptoms, especially chronic wounds that bring great pain to patients, and there is currently no effective and widely used wound dressing. Therefore, it is important to develop new multifunctional wound dressings. Hydrogel is an ideal dressing candidate because of its 3D structure, good permeability, excellent biocompatibility, and ability to provide a moist environment for wound repair, which overcomes the shortcomings of traditional dressings. This article first briefly introduces the skin wound healing process, then the preparation methods of hydrogel dressings and the characteristics of hydrogel wound dressings made of natural biomaterials and synthetic materials are introduced. Finally, the development prospects and challenges of hydrogel wound dressings are discussed.

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“…Eventually, this benlysta loaded sodium alginate hydrogel will give new ideas for the treatment and management of skin tissue defects. 38 Recently, self-healing hydrogels as a replenishable substance had received considerable interest. Besides, the poor biocompatibility and long self-healing duration of the traditional self-healing hydrogel limited their application in skin tissue regeneration.…”

Section: Alginatementioning

confidence: 99%

Polymeric Hydrogel Scaffolds: Skin Tissue Engineering and Regeneration

et al. 2021

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Tissue engineering is a novel regenerative approach in the medicinal field that promises the regeneration of damaged tissues. Moreover, tissue engineering involves synthetic and natural biomaterials that facilitate tissue or organ growth outside the body. Not surprisingly, the demand for polymer-based therapeutical approaches in skin tissue defects has increased at an effective rate, despite the pressing clinical need. Among the 3D scaffolds for tissue engineering and regeneration approaches, hydrogel scaffolds have shown significant importance for their use as 3D cross-linked scaffolds in skin tissue regeneration due to their ideal moisture retention property and porosity biocompatibility, biodegradable, and biomimetic characteristics. In this review, we demonstrated the choice of ideal biomaterials to fabricate the novel hydrogel scaffolds for skin tissue engineering. After a short introduction to the bioactive and drug-loaded polymeric hydrogels, the discussion turns to fabrication and characterisation techniques of the polymeric hydrogel scaffolds. In conclusion, we discuss the excellent wound healing potential of stem cell-loaded hydrogels and Nano-based approaches to designing hydrogel scaffolds for skin tissue engineering.

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Benlysta-Loaded Sodium Alginate Hydrogel and Its Selective Functions in Promoting Skin Cell Growth and Inhibiting Inflammation

Cited by 16 publications

References 37 publications

Designing a new alginate-fibrinogen biomaterial composite hydrogel for wound healing

Designing a new alginate-fibrinogen biomaterial composite hydrogel for wound healing

Hydrogel Preparation Methods and Biomaterials for Wound Dressing

Polymeric Hydrogel Scaffolds: Skin Tissue Engineering and Regeneration

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