Preparative isolation and purification of germacrone and curdione from the essential oil of the rhizomes of Curcuma wenyujin by high-speed counter-current chromatography

Yan, Jizhong; Chen, Gang; Tong, Shengqiang; Feng, Yeping; Sheng, Liuqing; Lou, Jianzhong

doi:10.1016/j.chroma.2005.02.064

Cited by 67 publications

(43 citation statements)

References 8 publications

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“…7 The volatile components in different species of genus Curcuma have been studied by many research groups. 8,9 The main objective of our research was to characterize and differentiate the composition of volatiles from the roots and rhizomes of C. wenyujin for potential large-scale production of medical essential oils and flavor essences. In addition, the content analysis of the volatiles of roots of C. wenyujin from 3 different harvesting time can help to optimize the harvesting time.…”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of the Volatile Components in the Fresh Roots and Rhizomes of Curcuma wenyujin by Static Headspace Gas Chromatography Mass Spectrometry

et al. 2006

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Static headspace GC-MS method coupled with H/D exchange was firstly developed to determine and identify the volatile components in the fresh root and rhizome of Curcuma wenyujin. The TIC chromatograms of 3 batches of fresh roots harvested at different time showed significant difference in the volatile components: the constitution was the same but the content of them was different. More than 60 volatile components in fresh roots (Root of C. wenyujin) and rhizomes (Rhizome of C. wenyujin) of C. wenyujin were detected, of which 51 and 48 volatile components were identified respectively. The fresh roots and rhizomes of C. wenyujin were found to have the similar volatile components. The contents of these components were calibrated by the response of β-elemene. In addition, the principal active component, β-elemene, was further confirmed and relatively quantified by its standard. γ-terpinene showed obvious allylic hydrogen/deuterium exchange using deuterium oxide which gave a new method to identify some compounds containing allylic hydrogen. At the same time, the active hydrogen compounds were also further confirmed. The results show that HS-GC-MS method is a fast, simple and efficient way for the analysis of volatile components from medical plants.

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Section: Introductionmentioning

confidence: 99%

Comparative Analysis of the Volatile Components in the Fresh Roots and Rhizomes of Curcuma wenyujin by Static Headspace Gas Chromatography Mass Spectrometry

et al. 2006

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“…1 (Hikino et al, 1967;Yan et al, 2005;Deng et al, 2006;Jiang et al, 2010;Hou et al, 2011;Xia et al, 2012). Glimepiride (C 24 H 34 N 4 O 5 S, purity 99.9%, Fig.…”

Section: Chemicalsmentioning

confidence: 96%

The toxicokinetic profile of curdione in pregnant SD rats and its transference in a placental barrier system detected by LC–MS/MS

Meng

Zhang

Liu

et al. 2015

Regulatory Toxicology and Pharmacology

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“…Yan et al (2005) developed a HSCCC method to isolate and purify sesquiterpenes including germacrone and curdione from the rhizomes of Curcuma wenyujin [100]. This method successfully performed the isolation and purification process with two-phase solvent system composed of petroleum etherethanol-diethyl ether-water (5/4/0.5/1, v/v) in tail to head elution mode, and 62 mg of germacrone, 93mg of curdione were isolated with 95% purity.…”

Section: High-speed Counter-current Chromatographymentioning

confidence: 99%

Chemical Analysis of the Chinese Herbal Medicine Turmeric (Curcuma longa L.)

Li¹,

Xiang²,

Xing³

et al. 2010

CPA

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Turmeric (Curcuma longa L., Zingiberaceae family) is a well known Chinese herbal medicine. It possesses diverse pharmacologic effects including antioxidant, anti-inflammatory, antiproliferative and antiangiogenic activities. The main bioactive constituents of C. longa include sesquiterpenes, which are responsible for its aroma, and curcuminoids, which contribute to its bright yellow color. Both sesquiterpenes and curcuminoids exhibit great potential as therapeutic agents for various diseases including colon cancer, pancreatic cancer, diabetes and Alzheimer's disease. Particularly, curcumin, one of the major curcuminoids of turmeric, has been proved to be effective in cancer treatment and prevention by recent phase I clinical trials. In order to ensure the efficacy and safety of turmeric in clinical applications, sensitive and accurate analytical methods are of significance for the comprehensive quality control of C. longa. This review summarizes recent progress in the chemical analysis of sesquiterpenes and curcuminoids in turmeric.

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Preparative isolation and purification of germacrone and curdione from the essential oil of the rhizomes of Curcuma wenyujin by high-speed counter-current chromatography

Cited by 67 publications

References 8 publications

Comparative Analysis of the Volatile Components in the Fresh Roots and Rhizomes of Curcuma wenyujin by Static Headspace Gas Chromatography Mass Spectrometry

Comparative Analysis of the Volatile Components in the Fresh Roots and Rhizomes of Curcuma wenyujin by Static Headspace Gas Chromatography Mass Spectrometry

The toxicokinetic profile of curdione in pregnant SD rats and its transference in a placental barrier system detected by LC–MS/MS

Chemical Analysis of the Chinese Herbal Medicine Turmeric (Curcuma longa L.)

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