Preparation, structural and microstructural characterization of Ti-25Ta-10Zr alloy for biomedical applications

Quadros, Fernanda de Freitas; Kuroda, Pedro Akira Bazaglia; Sousa, Karolyne dos Santos Jorge; Donato, Tatiani Ayako Goto; Grandini, Carlos Roberto

doi:10.1016/j.jmrt.2019.07.020

Cited by 32 publications

(23 citation statements)

References 37 publications

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“…Several works in the literature use this technique to produce metallic alloys [30][31][32] . In these works alloys with the tantalum elements in the chemical composition, melting point exceeding 3,273 K are satisfactorily produced [33][34][35] .…”

Section: Methodsmentioning

confidence: 99%

Development of novel Ti-Mo-Mn alloys for biomedical applications

Lourenço

Cardoso

Sousa

et al. 2020

Sci Rep

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Due to excellent biocompatibility and corrosion resistance, the application of titanium alloys in orthopedic and dental implants has been increasing since the 1970s. However, the elasticity of these alloys as measured by their Young’s modulus is still about two to four times higher than that of human cortical bone. The most widely used titanium alloy for biomedical applications is Ti-6Al-4V, however, previous studies have shown that the vanadium used in this alloy causes allergic reactions in human tissue and aluminum, also used in the alloy, has been associated with neurological disorders. To solve this problem, new titanium alloys without the presence of these elements and with the addition of different elements, usually beta-stabilizers, are being developed. Manganese is a strong candidate as an alloying element for the development of new beta-type titanium alloys, due to its abundance and low cytotoxicity. In this study, Ti-10Mo-5Mn, Ti-15Mo-2.5Mn and Ti-15Mo-5Mn alloys were prepared in an arc furnace, which resulted in an alloy structure clearly showing the predominance of the beta phase with a body-centered cubic crystalline structure. The observed microstructure confirmed the results on the structural characterization of alloys. Measurement of the indirect cytotoxicity of the alloys showed that the extracts of the studied alloys are not cytotoxic for fibroblastic cells.

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Section: Methodsmentioning

confidence: 99%

Development of novel Ti-Mo-Mn alloys for biomedical applications

Lourenço

Cardoso

Sousa

et al. 2020

Sci Rep

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“…Several works in the literature use the arc fusion technique for the production of titanium alloys. 13,14,16,[19][20][21][22][23][24][25][26][27] This type of furnace is capable of melting high melting materials such as tantalum, so it is known that the furnace is capable of exceeding 3017°C, which is sufficient to reach the melting point of titanium and niobium. The obtained ingot was thermomechanically worked by means of hot swaging to suit the geometric needs of the characterization equipment.…”

Section: Sample Preparationmentioning

confidence: 99%

“…For in vitro cytotoxicity tests, the MC3T3-E1 cell lineage subclone 14 was used (pre-osteoblasts of mouse calvarium, ATCC). 13,31,32 The trials were performed according to Donato et al procedure. For the direct MTT, the cells were grown on Ti-15Nb alloys (four-millimeter diameter by 1.5 mm thick discs) for 48 hours.…”

Section: Cytotoxicity Analysismentioning

confidence: 99%

“…12 Studies show that titanium alloys with the bcc crystalline structure have lower elastic modulus values. [13][14][15][16] Because of this, titanium alloys are more promising than cp-Ti, because the elements β-stabilizers decrease the transition temperature to values close to room temperature, decreasing the elastic modulus value of the material.…”

Section: Introductionmentioning

confidence: 99%

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Preparation, structural, microstructural, mechanical, and cytotoxic characterization of Ti‐15Nb alloy for biomedical applications

et al. 2020

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Titanium and its alloys are widely used in the manufacturing of orthopedic prostheses because of certain favorable characteristics titanium possesses. 1 Specifically, titanium has good biocompatibility, a good mechanical strength/density ratio, and a high level of resistance to corrosion. 2 The titanium alloy most used for orthopedic applications is Ti-6Al-4V, 3,4 but studies have shown that vanadium causes allergic reactions in human tissues, 5 and aluminum has been

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“…Titanium alloys are widely used as biomedical metal materials for artificial joints, fracture fixation, spine implantations, soft tissue reconstruction, and other situations because of their good biocompatibility, stable physical and chemical properties, and elastic modulus similar to human bone [1][2][3][4]. Many scholars have reported the hot deformation behaviors of titanium alloys.…”

Section: Introductionmentioning

confidence: 99%