Preparation, physicochemical characterization and in vitro release behavior of resveratrol-loaded oxidized gellan gum/resistant starch hydrogel beads

Wang, Peng; Luo, Zhigang; Xiao, Zhigang

doi:10.1016/j.carbpol.2021.117794

Cited by 72 publications

(18 citation statements)

References 51 publications

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“…FT-IR analysis was performed to identify interactions between GG, crosslinked GG, SF, crosslinked SF, CS, and mixture hydrogels (Figure 1). The specific peaks of the GG were detected at 3300 cm⁻ 1 (-OH stretching group), 1596 cm⁻ 1 (C-H2 stretching vibration group), and 1035 cm −1 (-COC stretching group) [40]. CS represented a specific peak similar to GG [41].…”

Section: Ft-ir Analysismentioning

confidence: 97%

Development and Evaluation of Gellan Gum/Silk Fibroin/Chondroitin Sulfate Ternary Injectable Hydrogel for Cartilage Tissue Engineering

et al. 2021

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Hydrogel is in the spotlight as a useful biomaterial in the field of drug delivery and tissue engineering due to its similar biological properties to a native extracellular matrix (ECM). Herein, we proposed a ternary hydrogel of gellan gum (GG), silk fibroin (SF), and chondroitin sulfate (CS) as a biomaterial for cartilage tissue engineering. The hydrogels were fabricated with a facile combination of the physical and chemical crosslinking method. The purpose of this study was to find the proper content of SF and GG for the ternary matrix and confirm the applicability of the hydrogel in vitro and in vivo. The chemical and mechanical properties were measured to confirm the suitability of the hydrogel for cartilage tissue engineering. The biocompatibility of the hydrogels was investigated by analyzing the cell morphology, adhesion, proliferation, migration, and growth of articular chondrocytes-laden hydrogels. The results showed that the higher proportion of GG enhanced the mechanical properties of the hydrogel but the groups with over 0.75% of GG exhibited gelling temperatures over 40 °C, which was a harsh condition for cell encapsulation. The 0.3% GG/3.7% SF/CS and 0.5% GG/3.5% SF/CS hydrogels were chosen for the in vitro study. The cells that were encapsulated in the hydrogels did not show any abnormalities and exhibited low cytotoxicity. The biochemical properties and gene expression of the encapsulated cells exhibited positive cell growth and expression of cartilage-specific ECM and genes in the 0.5% GG/3.5% SF/CS hydrogel. Overall, the study of the GG/SF/CS ternary hydrogel with an appropriate content showed that the combination of GG, SF, and CS can synergistically promote articular cartilage defect repair and has considerable potential for application as a biomaterial in cartilage tissue engineering.

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Section: Ft-ir Analysismentioning

confidence: 97%

Development and Evaluation of Gellan Gum/Silk Fibroin/Chondroitin Sulfate Ternary Injectable Hydrogel for Cartilage Tissue Engineering

et al. 2021

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“…According to the report, GG could easily form a gel at low concentrations under the existence of divalent (Ca 2+ ) and mono (sodium ion, potassium ion) cations . The oxidative modification of GG is through the introduction of carboxyl groups to make it have a certain pH sensitivity, thereby improving water solubility and lowering the gelation temperature …”

Section: Origin and Properties Of Polysaccharide Hydrogelsmentioning

confidence: 99%

“…Gellan gum (GG) is a linear water-soluble anionic extracellular polysaccharide, secreted by Pseudomonas elodea, and produced by β-D-glucose, β-D-glucuronic acid, α-L-rhamnose and β-D-glucose. 53 GG is considered safe, with gelling, biocompatibility, and biodegradable properties, and is also a food additive, acting as a stabilizer, thickener, and gelling agent in a variety of foods. Recently, due to the low cytotoxicity of GG, GG as a substance delivery agent and cell carrier in biomedical engineering has been studied.…”

Section: ■ Introductionmentioning

confidence: 99%

“…55 The oxidative modification of GG is through the introduction of carboxyl groups to make it have a certain pH sensitivity, thereby improving water solubility and lowering the gelation temperature. 53 Hyaluronic Acid-Derived Polysaccharides. Hyaluronic acid (HA) is a linear copolymer of 2-acetamido-2-deoxy-Dglucose and D-glucuronic acid.…”

Section: ■ Introductionmentioning

confidence: 99%

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Recent Advances of Stimuli-Responsive Polysaccharide Hydrogels in Delivery Systems: A Review

Zhang

Dong

Liu

et al. 2022

J. Agric. Food Chem.

101

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Hydrogels obtained from natural polymers have received widespread attention for their excellent biocompatible property, nontoxicity, easy gelation, and functionalization. Polysaccharides can regulate the gut microbiota and improve the intestinal microenvironment, thus exerting the healthy effect of intestinal immunity. In an active substance delivery system, the extent and speed of the substance reaching its target are highly dependent on the carrier. Thus, the smart active substance delivery systems are gradually increasing. The smart polysaccharide-hydrogels possess the ability in response to external stimuli through changing their volume phase and structure, which are applied in various fields. Natural polysaccharide-based hydrogels possess excellent characteristics of environmental friendliness, good biocompatibility, and abundant sources. According to the response type, natural polysaccharide-based hydrogels are usually divided into stimulus-responsive hydrogels, including internal response (pH, temperature, enzyme, redox) and external response (light, electricity, magnetism) hydrogels. The delivery system based on polysaccharides can exert their effects in the gastrointestinal tract. At the same time, polysaccharides may also take part in regulating the brain signals through the microbiota-gut-brain axis. Therefore, natural polysaccharide-hydrogels are considered as promising biomaterials, which can be designed as delivery systems for regulating the gut-brain axis. This article reviews the research advance of stimulus-responsive hydrogels, which focus on the types, response characteristics, and applications for polysaccharide-based smart hydrogels as delivery systems.

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“…In general, starch presents good properties for film formation [32][33][34][35], particulate systems [36,37], and gel formation [38][39][40][41][42], and is adequate for incorporating bioactive substances in controlled-release devices. An example of the process and its applications can be seen in Figure 2.…”

Section: Starchmentioning

confidence: 99%

Starch as a Matrix for Incorporation and Release of Bioactive Compounds: Fundamentals and Applications

et al. 2022

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Due to its abundance in nature and low cost, starch is one of the most relevant raw materials for replacing synthetic polymers in a number of applications. It is generally regarded as non-toxic, biocompatible, and biodegradable and, therefore, a safe option for biomedical, food, and packaging applications. In this review, we focused on studies that report the use of starch as a matrix for stabilization, incorporation, or release of bioactive compounds, and explore a wide range of applications of starch-based materials. One of the key application areas for bioactive compounds incorporated in starch matrices is the pharmaceutical industry, especially in orally disintegrating films. The packaging industry has also shown great interest in using starch films, especially those with antioxidant activity. Regarding food technology, starch can be used as a stabilizer in nanoemulsions, thus allowing the incorporation of bioactive compounds in a variety of food types. Starch also presents potential in the cosmetic industry as a delivery system. However, there are still several types of industry that could benefit from the incorporation of starch matrices with bioactive compounds, which are described in this review. In addition, the use of microbial bioactive compounds in starch matrices represents an almost unexplored field still to be investigated.

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Preparation, physicochemical characterization and in vitro release behavior of resveratrol-loaded oxidized gellan gum/resistant starch hydrogel beads

Cited by 72 publications

References 51 publications

Development and Evaluation of Gellan Gum/Silk Fibroin/Chondroitin Sulfate Ternary Injectable Hydrogel for Cartilage Tissue Engineering

Development and Evaluation of Gellan Gum/Silk Fibroin/Chondroitin Sulfate Ternary Injectable Hydrogel for Cartilage Tissue Engineering

Recent Advances of Stimuli-Responsive Polysaccharide Hydrogels in Delivery Systems: A Review

Starch as a Matrix for Incorporation and Release of Bioactive Compounds: Fundamentals and Applications

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