Preparation, physicochemical characterization and antioxidant activity of diphenyl diselenide-loaded poly(lactic acid) nanoparticles

Antunes, Osmar dos Reis; Antônio, Emilli; Mainardes, Rubiana Mara; Khalil, Najeh Maissar

doi:10.1016/j.jtemb.2016.09.010

Cited by 14 publications

(2 citation statements)

References 66 publications

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“…The C–CH 3 stretching vibration was assigned to the peak at 1041.5 cm −1 . The peak at 867.1 cm −1 was ascribed to the amorphous crystalline phase [ 18 , 19 , 20 ].…”

Section: Resultsmentioning

confidence: 99%

Effect of High Pressure Treatment on Poly(lactic acid)/Nano–TiO2 Composite Films

Chi

Fan

et al. 2018

Molecules

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The microstructure, thermal properties, mechanical properties and oxygen and water vapor barrier properties of a poly(lactic acid) (PLA)/nano-TiO2 composite film before and after high pressure treatment were studied. Structural analysis showed that the functional group structure of the high pressure treated composite film did not change. It was found that the high pressure treatment did not form new chemical bonds between the nanoparticles and the PLA. The micro-section of the composite film after high pressure treatment became very rough, and the structure was depressed. Through the analysis of thermal and mechanical properties, high pressure treatment can not only increase the strength and stiffness of the composite film, but also increase the crystallinity of the composite film. Through the analysis of barrier properties, it is found that the barrier properties of composite films after high pressure treatment were been improved by the applied high pressure treatment.

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“…The C–CH 3 stretching vibration was assigned to the peak at 1041.5 cm −1 . The peak at 867.1 cm −1 was ascribed to the amorphous crystalline phase [ 18 , 19 , 20 ].…”

Section: Resultsmentioning

confidence: 99%

Effect of High Pressure Treatment on Poly(lactic acid)/Nano–TiO2 Composite Films

Chi

Fan

et al. 2018

Molecules

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“…The in vitro release profile of MLT from PLA nanoparticles was determined by dissolution followed by ultracentrifugation [42] . An aqueous suspension of nanoparticles containing about 1 mg of MLT was dispersed in 10 mL of phosphate saline buffer (PBS, 0.01 M, pH 7.4) containing 1% tween® 80 (m/v), to maintain sink conditions.…”

Section: Methodsmentioning

confidence: 99%

Application of a validated HPLC-PDA method for the determination of melatonin content and its release from poly(lactic acid) nanoparticles

Martins

Khalil

Mainardes

2017

Journal of Pharmaceutical Analysis

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Melatonin is a natural hormone and with the advancement of age its production declines and thereby may result in some neurological disorders. Exogenous administration of melatonin has been suggested as a neuroprotective agent. Due to its low oral bioavailability, the loading of melatonin in polymeric nanoparticles could be an important tool to effectively use exogenous melatonin. The quantification of the incorporated drug within polymeric nanoparticles is an important step in nanoparticles characterization. An analytical method using high performance liquid chromatography equipped with photodiode array detector (HPLC-PDA) was developed and validated for melatonin determination in poly (lactic acid) nanoparticles obtained by a single emulsion-solvent evaporation technique. The melatonin in vitro release profile also was determined by the HPLC method. Mobile phase consisted of acetonitrile: water (65:35, v/v) pumped at a flow rate of 0.9 mL/min, in the isocratic mode and PDA detector was set at 220 nm. The method was validated in terms of the selectivity, linearity, precision, accuracy, robustness, limits of detection and quantification. Analytical curve was linear over the concentration range of 10–100 μg/mL, and limits of detection and quantification were 25.9 ng/mL and 78.7 ng/mL, respectively. The mean recovery for melatonin was 100.47% (RSD = 1.25%, n = 9). In the intra- and inter-assay, the coefficient of variation was less than 2%. Robustness was proved performing changes in mobile phase, column temperature and flow rate. The method was suitable for the determination of melatonin encapsulation efficiency in poly(lactic acid) nanoparticles and for the evaluation of melatonin in vitro release profile.

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Effect of multiscale structure on the gas barrier properties of poly(lactic acid)/Ag nanocomposite films

Fan

Chi

Zhang

et al. 2019

Polymers for Advanced Techs

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Poly(lactic acid) (PLA) is the most suitable for biodegradable packaging film because of its excellent integrated property, but the poor gas barrier property is its weakness. In this study, a nanocomposite film based on PLA incorporated with 0‐, 1‐, 3‐, 5‐, 10‐, or 15‐wt% nano‐Ag was developed. Effect of multiscale structure on the barrier properties of PLA/nano‐Ag films was studied. The PLA nanocomposite film with 5‐wt% nano‐Ag had the lowest water vapor permeability (WVP) value. Oxygen transmission rate (OTR) value for PLA nanocomposites with 3‐wt% nano‐Ag was found to be the lowest among all the samples. Multiscale structure was demonstrated by the scanning electron microscopy, Fourier transform‐infrared spectroscopy, X‐ray diffraction measurement, and differential scanning calorimetry results. The crystallinity of the PLA phase increased with the content of nano‐Ag in the PLA composites. The evolution of the PLA phase crystallinity could improve the barrier properties of PLA/nano‐Ag composite films for food packaging applications. From the view of multiscale structure, it is better to achieve a balance among short‐range conformation in the amorphous region, long‐range‐ordered structure, and ordered aggregated structure to improve the barrier properties of PLA/nano‐Ag composite films.

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Preparation, physicochemical characterization and antioxidant activity of diphenyl diselenide-loaded poly(lactic acid) nanoparticles

Cited by 14 publications

References 66 publications

Effect of High Pressure Treatment on Poly(lactic acid)/Nano–TiO2 Composite Films

Effect of High Pressure Treatment on Poly(lactic acid)/Nano–TiO2 Composite Films

Application of a validated HPLC-PDA method for the determination of melatonin content and its release from poly(lactic acid) nanoparticles

Effect of multiscale structure on the gas barrier properties of poly(lactic acid)/Ag nanocomposite films

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