Preparation, physicochemical characterization, and anti-proliferation of selenium nanoparticles stabilized by Polyporus umbellatus polysaccharide

Guan, Xiong; Li, Xiaofei; Mu, Jingjing; Ho, Chi Tang; Su, Juanjuan; Zhang, Yuting; Lin, Xiaorong; Chen, Zhongzheng; Li, Bin; Xie, Yizhen

doi:10.1016/j.ijbiomac.2020.02.199

Cited by 92 publications

(45 citation statements)

References 59 publications

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“…Nanoscale selenium has attracted the attention of scientists due to its bioavailability and lower toxicity compared to the other forms of selenium [269]. Gao et al studied the antioxidant properties of SeNPs and demonstrated the reduced risk of selenium toxicity [187]. Moreover, SeNPs can be used as an antioxidant in food additives due to their lower risk of toxicity.…”

Section: Bioapplications Of Senps and Tenpsmentioning

confidence: 99%

Green Synthesis of Selenium and Tellurium Nanoparticles: Current Trends, Biological Properties and Biomedical Applications

Zambonino

Quizhpe

Jaramillo

et al. 2021

IJMS

107

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The synthesis and assembly of nanoparticles using green technology has been an excellent option in nanotechnology because they are easy to implement, cost-efficient, eco-friendly, risk-free, and amenable to scaling up. They also do not require sophisticated equipment nor well-trained professionals. Bionanotechnology involves various biological systems as suitable nanofactories, including biomolecules, bacteria, fungi, yeasts, and plants. Biologically inspired nanomaterial fabrication approaches have shown great potential to interconnect microbial or plant extract biotechnology and nanotechnology. The present article extensively reviews the eco-friendly production of metalloid nanoparticles, namely made of selenium (SeNPs) and tellurium (TeNPs), using various microorganisms, such as bacteria and fungi, and plants’ extracts. It also discusses the methodologies followed by materials scientists and highlights the impact of the experimental sets on the outcomes and shed light on the underlying mechanisms. Moreover, it features the unique properties displayed by these biogenic nanoparticles for a large range of emerging applications in medicine, agriculture, bioengineering, and bioremediation.

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Section: Bioapplications Of Senps and Tenpsmentioning

confidence: 99%

Green Synthesis of Selenium and Tellurium Nanoparticles: Current Trends, Biological Properties and Biomedical Applications

Zambonino

Quizhpe

Jaramillo

et al. 2021

IJMS

107

View full text Add to dashboard Cite

show abstract

“…In brief, MDCK cells were treated with SeNPs for 48 h, and then lysed in cell lysis buffer for 1 h. After centrifugation, 50 μL of cell lysate was mixed with 50 μL of reaction buffer, and then added to the 96-well plate. Then, 5 μL of the caspase substrate was added into each well and the plate was incubated at 37℃ in the dark for 1 h. The absorbance values were measured at 380 nm (excitation) and 460 nm (emission) and caspase activity was expressed as fold change compared to the control group [29]. Then we will use TUNEL apoptosis detection kit was used to detect DNA fragmentation with uorescence staining.…”

Section: Caspase-3 Activitymentioning

confidence: 99%

Selenium Nanoparticles Inhibited H1N1 Influenza Virus Induced Apoptosis By Improving The Level of Gpx1

Liu

Chen

et al. 2021

Preprint

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Influenza A (H1N1) viruses are distributed around the world and pose a threat to public health. Vaccination is the main treatment strategy to prevent influenza infection, but antiviral drugs also play an important role in controlling seasonal and pandemic influenza. Currently, influenza viruses may emerge antiviral resistance, new agents with different modes of action are being investigated. Recently, selenium nanoparticles (SeNPs) which have antiviral effects attracted more and more attention in biomedical interventions. The appearance of nanotechnology attract great attention in the nanomedicine field. SeNPs constitute an attractive vector platform for delivering a variety of drugs to action targets. SeNPs is being explored for potential therapeutic efficacy in a variety of oxidative stress and inflammation-mediated diseases, such as cancer, arthritis, diabetes, and kidney disease. SeNPs could inhibit infection of Madin Darby Canine Kidney (MDCK) cells with H1N1 and prevent chromatin condensation and DNA fragmentation. ROS play a key role in physiological processes on apoptosis. SeNPs significantly inhibited the production of reactive oxygen species (ROS) in MDCK cells. Mechanistic investigation revealed that SeNPs inhibited the apoptosis induced by H1N1 virus infection in MDCK cells by improving the level of GPx1. Our results suggest that SeNPs is an effective selenium source to obtain H1N1 influenza antiviral candidate.

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“…Infrared spectral analysis: The IR spectrum of the POPs-I is shown in Figure 3. The broad bands at 3440.1 cm −1 were assigned to the ν(O-H) stretching vibrations of hydrogen-bonded and free hydroxyl groups [28], and the signal at 2921.7 cm −1 was attributed to ν(C-H) stretching of CH 2 groups [14,29], at 1631.8 cm −1 corresponded to the absorption of the carboxylate anions was (O=C-O) of nonesterified groups in pectins [28], and near the signal at 1378.8 cm −1 was COO− symmetric stretching vibration.…”

Section: Polysaccharide Concentrationmentioning

confidence: 99%

“…The peak at 1262.7 cm −1 was ν(C-O), and the absorption bands analysis of the spectrum in the 1092.6 cm −1 , 1026.3 cm −1 regions showed specific bands typical for a pyranose ring vibration [28,29]. The peak at 868.7 cm −1 indicated the presence of β-glycosidic linkage in the molecular structure of the polysaccharides [14,28].…”

Section: Polysaccharide Concentrationmentioning

confidence: 99%

The study on the antioxidant activity of polysaccharides isolated from Polygonatum odoratum (Mill.) Druce

et al. 2020

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The polysaccharides isolated from Polygonatum odoratum (Mill.) Druce (POPs) by water extraction, after precipitation with ethanol were purified through deproteinization, decolorization, dialysis, and column chromatography leading to a purified polysaccharide (POPs-I) content of 90.7 %. The scavenging of oxygen free radicals and inhibition of lipid peroxidation (LPO) by POPs-I were analyzed using a colorimetric method. The results showed that the hydroxyl radical scavenging ability of the polysaccharides was weaker than that of benzoic acid, but stronger than those of ascorbic acid and mannitol, and that the superoxide anion radical scavenging ability was inferior to those of all three. When the concentration was higher than 1.0 mg/mL, the POPs-I could inhibit LPO by superoxide anion radicals to a certain degree. Therefore, this work suggests that POPs-I are potential antioxidant agents in medicine and functional food.

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Preparation, physicochemical characterization, and anti-proliferation of selenium nanoparticles stabilized by Polyporus umbellatus polysaccharide

Cited by 92 publications

References 59 publications

Green Synthesis of Selenium and Tellurium Nanoparticles: Current Trends, Biological Properties and Biomedical Applications

Green Synthesis of Selenium and Tellurium Nanoparticles: Current Trends, Biological Properties and Biomedical Applications

Selenium Nanoparticles Inhibited H1N1 Influenza Virus Induced Apoptosis By Improving The Level of Gpx1

The study on the antioxidant activity of polysaccharides isolated from Polygonatum odoratum (Mill.) Druce

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