Selenium Nanoparticles Inhibited H1N1 Influenza Virus Induced Apoptosis By Improving The Level of Gpx1

Abstract

Influenza A (H1N1) viruses are distributed around the world and pose a threat to public health. Vaccination is the main treatment strategy to prevent influenza infection, but antiviral drugs also play an important role in controlling seasonal and pandemic influenza. Currently, influenza viruses may emerge antiviral resistance, new agents with different modes of action are being investigated. Recently, selenium nanoparticles (SeNPs) which have antiviral effects attracted more and more attention in biomedical interventions. The appearance of nanotechnology attract great attention in the nanomedicine field. SeNPs constitute an attractive vector platform for delivering a variety of drugs to action targets. SeNPs is being explored for potential therapeutic efficacy in a variety of oxidative stress and inflammation-mediated diseases, such as cancer, arthritis, diabetes, and kidney disease. SeNPs could inhibit infection of Madin Darby Canine Kidney (MDCK) cells with H1N1 and prevent chromatin condensation and DNA fragmentation. ROS play a key role in physiological processes on apoptosis. SeNPs significantly inhibited the production of reactive oxygen species (ROS) in MDCK cells. Mechanistic investigation revealed that SeNPs inhibited the apoptosis induced by H1N1 virus infection in MDCK cells by improving the level of GPx1. Our results suggest that SeNPs is an effective selenium source to obtain H1N1 influenza antiviral candidate.