Preparation of Uniform-Sized Multiple Emulsions and Micro/Nano Particulates for Drug Delivery by Membrane Emulsification

Liu, Wei; Yang, Xiangliang; Ho, W.S. Winston

doi:10.1002/jps.22272

Cited by 77 publications

(30 citation statements)

References 150 publications

(225 reference statements)

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“…Another additional advantage of membrane emulsification is the easy process scaleup which can be carried out, keeping the performance demonstrated at the laboratory scale [19]. So far, membrane emulsification has been investigated for microencapsulation of water soluble and lipophilic drugs within W/O/W emulsions such as: ethanol-oil-water E/O/W; and water-oil-water W/O/W [20,21] or within microspheres and capsules produced in most cases by coacervation, interfacial polymerization and solvent evaporation [22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Polycaprolactone multicore-matrix particle for the simultaneous encapsulation of hydrophilic and hydrophobic compounds produced by membrane emulsification and solvent diffusion processes

Imbrogno

Dragosavac

Piacentini

et al. 2015

Colloids and Surfaces B: Biointerfaces

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Section: Introductionmentioning

confidence: 99%

Polycaprolactone multicore-matrix particle for the simultaneous encapsulation of hydrophilic and hydrophobic compounds produced by membrane emulsification and solvent diffusion processes

Imbrogno

Dragosavac

Piacentini

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…As discussed above, such methods suffer from intrinsic low reproducibility and production efficiency, and limited control on particle size that strongly bias industrial development. In the effort to meet industrial requirements, over the last two decades, membrane emulsification technology has taken the lead in particular in PLA and PLGA MP manufacturing (Liu et al 2005a(Liu et al , b, 2006(Liu et al , 2011Lloyd et al 2014;Ramazani et al 2016). The technique is based on a relatively simple concept.…”

Section: Membrane Emulsificationmentioning

confidence: 99%

Meeting the unmet: from traditional to cutting-edge techniques for poly lactide and poly lactide-co-glycolide microparticle manufacturing

Schoubben

Ricci

Giovagnoli

2019

J. Pharm. Investig.

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Background Polylactides (PLA) and poly lactide-co-glycolides (PLGA) undoubtedly are among the major drivers in the pharmaceutical market. Their relevance in pharmaceutics and biomedicine is well established in light of their sustainability, safety, tunable biodegradability, and versatility. However, polymer degradability and plasticity can somehow restrain industrial developability of PLA and PLGA formulations, especially in the form of microparticles (MP). Area covered This review wants to deal with the known manufacturing issues of PLA/PLGA MP, debating the potential contribution of modern and cutting-edge manufacturing technologies to the solution of unmet production needs. Technological and regulatory aspects will be considered outlining the potential role of advanced manufacturing techniques in the advancement of PLA/PLGA MP production processes. Expert opinion The multifaceted complexity of PLA/PLGA MP manufacturing processes demands adequate standardization and updated guidelines covering the so far unmet industrialization requirements. Novel and evolving manufacturing technologies will surely support the future development of bench-to-production plant transfer for such products. Careful evaluation of production costs is demanded in order to ensure process sustainability and patient's outreach.

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“…These procedures are not well-controlled by the particles size. Furthermore, these methods use large amounts of organic solvents or strong mechanical stirring force, resulting in the encapsulated biomolecules losing their bioactivities [9].…”

Section: Introductionmentioning

confidence: 99%

Novel DiR and SPIO nanoparticles embedded PEG-PLGA nanobubbles as a multimodalimaging contrast agent

Luo

Zhang

Liu

et al. 2015

BME

Self Cite

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Abstract. Fluorescence dye DiR and superparamagnetic iron oxide nanoparticles (SPIONs) embedded in PEG-PLGA nanobubbles (DiR-SPIO-NBs) were produced using double emulsion method on a membrane of Shirasu porous glass (SPG). The nanobubbles encapsulated with DiR and SPIONs had a liquid core (perfluoropentane) and a PEG-PLGA shell. DiR-SPIO-NBs showed biocompatibility based on MTT cytotoxicity and hemolysis studies. The PFP encapsulated in the nanobubbles experienced phase transition under ultrasonic irradation. Nanobubbles dispersed well in saline over 3 months and the relaxivity was 127.9 mM -1 s -1 , suggesting that it could be used as a contrast agent in MRI. The MR and fluorescence images in vivo demonstrated that the signal intensity in the spleen and liver was significantly enhanced with the treatment of nanobubbles. In addition, results of ultrasound images suggested that the nanobubbles had persistent contrast ability. In conclusion, nanobubbles could be utilized as an US/MRI/fluorescence contrast agent.

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Preparation of Uniform-Sized Multiple Emulsions and Micro/Nano Particulates for Drug Delivery by Membrane Emulsification

Cited by 77 publications

References 150 publications

Polycaprolactone multicore-matrix particle for the simultaneous encapsulation of hydrophilic and hydrophobic compounds produced by membrane emulsification and solvent diffusion processes

Polycaprolactone multicore-matrix particle for the simultaneous encapsulation of hydrophilic and hydrophobic compounds produced by membrane emulsification and solvent diffusion processes

Meeting the unmet: from traditional to cutting-edge techniques for poly lactide and poly lactide-co-glycolide microparticle manufacturing

Novel DiR and SPIO nanoparticles embedded PEG-PLGA nanobubbles as a multimodalimaging contrast agent

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